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Database: UniProt
Entry: F6Y932_XENTR
LinkDB: F6Y932_XENTR
Original site: F6Y932_XENTR 
ID   F6Y932_XENTR            Unreviewed;       740 AA.
AC   F6Y932;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a4 {ECO:0000313|Ensembl:ENSXETP00000062258};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000062258, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000062258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000062258};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000062258}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXETP00000062258}.
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DR   EMBL; AAMC01102827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSXETT00000064393; ENSXETP00000062258; ENSXETG00000011571.
DR   Xenbase; XB-GENE-493197; atp6v0a4.
DR   GeneTree; ENSGT00390000004941; -.
DR   Reactome; R-XTR-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-XTR-77387; Insulin receptor recycling.
DR   Reactome; R-XTR-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-XTR-983712; Ion channel transport.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000011571; -.
DR   ExpressionAtlas; F6Y932; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    304    333       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    353    372       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    478    502       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    674    696       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   740 AA;  83856 MW;  642EA059C5C4D229 CRC64;
     MASLFRSEEM SLTQLILQVE AGYCCIAELG ELGLVQFRDL NASVNSFQRR FVNEVRRCEN
     MERILPLIES LAQQVQGVLM LVNQAPVXPY PDPTIPYRAP HNNILGQHRA GLEPPRRGWL
     RSVSVLYMGP CVLQAEANLP DDFFSEDTSS LLELRTIPSA AAAGKLGFTA GVINRERMAT
     FERLLWRVCR GNIYLKYTEL DTALEDPVTK EEVKKNVFII FYQGDQLKLK IKKICDGSVT
     GILCQMKKIS NSKXTIAPIL TNISSKLDPP TFNRTNKFTS GFQNIVNAYG VGSYREMNPT
     PYTIITFPFL FAVMFGDCGH GSVMLGFALW MVLNEKQLLA SKTDNEIWNT FFGGRYLILL
     MSIFSIYTGF IYNDCFSKSF DIFGSSWRVR PMFINKTWND NLVHQGLQLQ LDPAVPGVYS
     GNPYPFGIDP IWNIAQNKLT FLNSYKMKMS VVMGITQMVF GVMLGLLNHI NFKRPINIIL
     QFIPEMIFII CLFGYLVFMI IFKWCKYDVH SSQGAPSILI HFINMFLFNY SDPTNAPLYE
     HQKEVQTFLV IFALIAVPWM LLIKPFVLRA NHLKAQRMGV INFWKLQSSS GPEDHAELTD
     VENAHANHKS KKEFDFGDIF VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWT
     MVMHQGLSIG GYGGLIGVFI IFAAFAVLTV AILLVMEGLS AFLHALRLHW VEFQNKFYAG
     TGHLFSPFSF QSILEGTDNE
//
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