ID F6Y970_HORSE Unreviewed; 675 AA.
AC F6Y970;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021278.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021278.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021278.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021278.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021278.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6Y970; -.
DR STRING; 9796.ENSECAP00000021278; -.
DR PaxDb; 9796-ENSECAP00000021278; -.
DR Ensembl; ENSECAT00000025575.3; ENSECAP00000021278.3; ENSECAG00000036026.2.
DR GeneTree; ENSGT01100000263511; -.
DR HOGENOM; CLU_000680_9_4_1; -.
DR InParanoid; F6Y970; -.
DR OMA; FAFINIC; -.
DR TreeFam; TF341604; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000036026; Expressed in oviduct epithelium and 20 other cell types or tissues.
DR CDD; cd01650; RT_nLTR_like; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR25952; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25952:SF246; LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1..185
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 675 AA; 79732 MW; A780D495F7DF4141 CRC64;
MKNKNHMIIS IDAEKAFDKI QHRFMIKTLS KMGIEGKYLN IIKAIYDKPT ANIILNGQKL
KAIPLRTGTR QGCPLSPLLF NIVLEVLARA IRQENEIKGI QIGNEEVKLS LFADDMILYI
ENPKESTEKL LEIINNYSKV AGYKINVHKS VAFLYTNNEL TEKELKNSIP FTIATKRIKY
LGINLTKEVK DLYNENYKTF LKEIDDDIKR WKDIPCTWIG RINIVKMSIL PKAIYRFNAI
PIRIPRTFFT EIEQTILKFI WGNKRPRIAK AILSKKNKAG RITIPDFKTY YKATVIKTAW
YWYKNRSTDQ WNRIESPEIK PHIYGQLIFD KGAEGLQWRK ESLFNKWCWE NWTATCKRLK
IDHSFSPHTK INSKWIKDLK IRPETISLLE ENIGSTLFDI SFKRIFSDTV TPQLRETIER
INKWDFIRLK SFFKARENRI ETKKQLTNWE KIFTSHLSDK GLISIIYKEL TLLNNKKTNN
LIKKWAEDMN RHFSKEDMNM ANRHMKRCSS SLIIREMQIE TTLRYHLTPV RLAKTPKTKS
DKCWRGCGEK GTLIHCWWEC KLIQPLWKTV WRFLKKLKIE IPYDPAIPLL GIYPKNLISE
ISRVRCTPMF IAALFTIAKT WNQPTCPETD DWIKKMWYIY TMEYYSAIKK DKIGPFTTTW
MDLEGIMLSE ISQSE
//
