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Database: UniProt
Entry: F6Y9V9_HORSE
LinkDB: F6Y9V9_HORSE
Original site: F6Y9V9_HORSE 
ID   F6Y9V9_HORSE            Unreviewed;      1977 AA.
AC   F6Y9V9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 42.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1C {ECO:0000313|Ensembl:ENSECAP00000019492};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019492, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000019492, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019492,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000019492}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019492};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000019492}.
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DR   PaxDb; F6Y9V9; -.
DR   Ensembl; ENSECAT00000023528; ENSECAP00000019492; ENSECAG00000019096.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000002281; Chromosome 6.
DR   Bgee; ENSECAG00000019096; -.
DR   ExpressionAtlas; F6Y9V9; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF240; PTHR10037:SF240; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      5     24       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     36     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    109    131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    223    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    366    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    403    426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    495    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    567    594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    737    759       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    779    800       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    812    838       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    858    887       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    983   1010       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1061   1082       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1094   1114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1200   1218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1294   1317       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1451   1485       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      597    623       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1977 AA;  222440 MW;  7F66F7B7E7E41C8A CRC64;
     ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAE
     GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
     IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG TVCKPGWDGP
     KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL
     VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDEE
     KPRNMSMPTS ETESVNTENV AGGDIEGENC GARLAHRISK SKFSRYWRRW NRFCRRKCRA
     AVKSNIFYWL VIFLVFLNTL TIASEHYNQP HWLTEVQDTA NKALLALFTT EMLLKMYSLG
     LQAYFVSLFN RFDCFIVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK ITRYWNSLSN
     LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF DNFPQSLLTV
     FQILTGEDWN SVMYDGIMAY GGPSFPGMLV CIYFIILFIC GNYILLNVFL AIAVDNLADA
     ESLTSAQKEE EEEKERKKLA RTASPEKKQE VVEKPAVEEA KEEKIELKSI TADGESPPTT
     KINMDDLQPN ENEDKSPYSN PETAGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA
     FFIFSPNNRF RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR NHILGNADYV
     FTSIFTLEII LKMTAYGAFL HKGSFCRNYF NILDLLVVSV SLISFGIQSS AINVVKILRV
     LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS
     DSSKQTEAEC KGNYITYKDG EVDHPIIQPR SWENSKFDFD NVLAAMMALF TVSTFEGWPE
     LLYRSIDSHT EDKGPIYNYR VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN
     CELDKNQRQC VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI LLNTICLAMQ
     HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKHYF CDAWNTFDAL IVVGSIVDIA
     ITEVNPAEHT QCSPFMNAEE NSRISITFFR LFRVMRLVKL LSRGEGIRTL LWTFIKSFQA
     LPYVALLIVM LFFIYAVIGM QVFGKIALND TTEINRNNNF QTFPQAVLLL FRCATGEAWQ
     DIMLACMPGK KCAPESEPSN STEGETPCGS SFAVFYFISF YMLCAFLIIN LFVAVIMDNF
     DYLTRDWSIL GPHHLDEFKR IWAEYDPEAK GRIKHLDVVT LLRRIQPPLG FGKLCPHRVA
     CKRLVSMNMP LNSDGTVMFN ATLFALVRTA LRIKTEGNLE QANEELRAII KKIWKRTSMK
     LLDQVVPPAG DDEVTVGKFY ATFLIQEYFR KFKKRKEQGL VGKPSQRNAL SLQAGLRTLH
     DIGPEIRRAI SGDLTAEEEL DKAMKEAVCA ASEDDIFRRA GGLFGNHVSY YQSDGRSAYP
     QTFTTQRPLH INKAGNSQGD TESPSHEKLV DSTFTPSSYS STGSNANINN ANNTALGRFP
     RPTGYPSAVS TVEGHGLPLS PAIRVQEAAW KLSSKRCPSR ESQIAMVCQE EVSHEETYDV
     KMSEDPQRGS EPSLISTERL SYQDDEHRQL TPPEEDKRDI RQSPKRGFLR SASLGRRASF
     HLECLKRQKS QGGDVSQKTV LPLHLVHHQA LAVAGLSPLL QRSRAPTTCP QPWATPSSQG
     WPPRPIPTLR LEGAESSEKL NSSFPSIHCG SWSGEPTACG GGSSALRRAR PVSLTVPSRA
     GAPGRQLHGS ASSLVEAVLI SEGLGQFAQD PKFIEVTTQE LADACDMTIE EMENAADNIL
     SGGTQQSANG TLFPFVNCRD PGQDRAGGEE NETCAPALER GKSEGEPQDS RACGGSL
//
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