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Database: UniProt
Entry: F6YBS7_HORSE
LinkDB: F6YBS7_HORSE
Original site: F6YBS7_HORSE 
ID   F6YBS7_HORSE            Unreviewed;      1259 AA.
AC   F6YBS7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Diaphanous related formin 1 {ECO:0000313|Ensembl:ENSECAP00000019206.3};
GN   Name=DIAPH1 {ECO:0000313|Ensembl:ENSECAP00000019206.3,
GN   ECO:0000313|VGNC:VGNC:17183};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019206.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000019206.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019206.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000019206.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019206.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC       subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR   Ensembl; ENSECAT00000023203.3; ENSECAP00000019206.3; ENSECAG00000020822.4.
DR   VGNC; VGNC:17183; DIAPH1.
DR   GeneTree; ENSGT00940000157822; -.
DR   TreeFam; TF315383; -.
DR   Proteomes; UP000002281; Chromosome 14.
DR   Bgee; ENSECAG00000020822; Expressed in blood and 23 other cell types or tissues.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.20.58.630; -; 1.
DR   Gene3D; 6.10.30.30; -; 1.
DR   Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR044933; DIA_GBD_sf.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR   PANTHER; PTHR45691:SF4; PROTEIN DIAPHANOUS HOMOLOG 1; 1.
DR   Pfam; PF06346; Drf_FH1; 2.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          84..449
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          806..1208
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   DOMAIN          1231..1259
FT                   /note="DAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51231"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          572..789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1190..1221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          481..568
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1089..1151
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        36..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        599..626
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..789
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1259 AA;  139349 MW;  EFD363131B363334 CRC64;
     MEPPGGGLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE RFTSMRIKKE
     KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML LDMNLNEEKQ QPLREKDIII
     KREMVSQYLH TSKAGMSQKE SSRSAMMYIQ ELRSGLRDMP LLSCLESLRV SLNNNPVSWV
     QTFGAEGLAS LLDILKRLHD EKEEIAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG
     ILLLVRAMDP AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD
     GLKSGTSIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQEL REIENDDMRV
     QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF SEVFQILLNT VKDSKAEPHF LSILQHLLLV
     RNDYEARPQY YKLIEECISQ IVLHKNGADP DFKCRHLQID IEGLIDQMID KTKVEISEAK
     ATELEKKLDS ELTARHELQV EMKKMESDFE QKLQDLQGEK DALDSEKQQI ATEKQGLEAE
     VSQLTGEVAK LSKELEDAKK EMASISAAVT AVAPPSSASV ASAPPLPGDS GTAKVGVSIS
     PPPPLPGSDT VPSPPPPPPP PPLPGGSYTS SSGSPLPGDV CISTPPPLPE GTIPPPPPLP
     EGTSIPPPPP LPVGTSIPPP PPLPGSASIP PPPPLPGSAS IPPPPPLPGS ASIPPPPPLP
     GGACIPLPPP LPGGACIPPP PPPLPGGPGM PPPPPPLPGG AGIPPPPPFP GGPGIPPPPP
     GMGMPPPPPF GFGVPAAPVL PFGLTPKKLY KPEVQLRRPN WSKFVAEDLS QDCFWTKVKE
     DRFENNELFA KLTLTFSAQT KTSKAKKDQE GGEEKKSVQK KKVKELKVLD SKTAQNLSIF
     LGSFRMPYQE IKNVILEVNE AVLTESMIQN LIKQMPEPEQ LKMLSELKDE YDDLAESEQF
     GVVMGTVPRL RPRLNAILFK LQFSEQVENI KPEIVSVTAA CEELRKSENF SSLLEITLLV
     GNYMNAGSRN AGAFGFSISF LCKLRDTKST DQKMTLLHFL AELCETDHPD VLKFPDELAH
     VEKASRVSAE NMQKNLDQMK KQISDVERDV QNFPAATDEK DKFVEKMTSF VKDAQEQYNK
     LRMMHSNMET LYKELGEYFL FDPKKVPVEE FFMDLHNFRN MFVQAVKENQ KRRETEEKMR
     RAKLAKEKAE KERLEKQQKR EQLIDMNAEG DETGVMDSLL EALQSGAAFR RKRGPRQGK
//
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