ID F6YEI2_HORSE Unreviewed; 1524 AA.
AC F6YEI2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|Ensembl:ENSECAP00000021357.2};
GN Name=TRPM2 {ECO:0000313|Ensembl:ENSECAP00000021357.2,
GN ECO:0000313|VGNC:VGNC:24557};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021357.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021357.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021357.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021357.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021357.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC
CC subfamily. TRPM2 sub-subfamily. {ECO:0000256|ARBA:ARBA00009501}.
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DR SMR; F6YEI2; -.
DR STRING; 9796.ENSECAP00000021357; -.
DR PaxDb; 9796-ENSECAP00000021357; -.
DR Ensembl; ENSECAT00000025661.4; ENSECAP00000021357.2; ENSECAG00000023430.4.
DR VGNC; VGNC:24557; TRPM2.
DR GeneTree; ENSGT00940000156404; -.
DR HOGENOM; CLU_001390_0_2_1; -.
DR InParanoid; F6YEI2; -.
DR OMA; EFLIYEP; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000002281; Chromosome 26.
DR Bgee; ENSECAG00000023430; Expressed in leukocyte and 18 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0015278; F:calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0072571; F:mono-ADP-D-ribose binding; IEA:Ensembl.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0071415; P:cellular response to purine-containing compound; IEA:Ensembl.
DR GO; GO:0071502; P:cellular response to temperature stimulus; IEA:Ensembl.
DR GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IEA:Ensembl.
DR CDD; cd03670; ADPRase_NUDT9; 1.
DR Gene3D; 3.40.50.450; -; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF2; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00022673};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT DOMAIN 1353..1497
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 173439 MW; 0BFA876F6F0EE519 CRC64;
MEPSTPWKAG SKQKEGFGGQ PRRVADLGAG PNLQRSDSSL PKNRRSQYLL GNCEKQKNLS
SWIPENIKKK ECMYFVESSK LSDAGKVVCE CGYTHEQHLE EATWPCAFQG KEWDPKKHVQ
EMPTDAFGDI AFMGLGQKVG KYVRLSQDTP SSVIYHLITQ HWGLDVPNLL ISVTGGAKDF
NMKPRLKNVF RRGLVKVAQT TGAWIITGGT HTGVMKQVGE AVRDFSLSSS YNEGEVVTIG
IATWGTLHNR EGLIHPTGGF PAEYIVDEDG QGHLTCLDSN HSHFILVDDG THGRYGVEIP
LRTKLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI YNAITNGTPC VIVEGSGRVA
DVIAQVAGLP ISEITISLIQ QKLSMFFQEM FETFTEGRIV EWTKKIQDIV RRRQLLTIFR
EGKDGQQDVD VAILQALLKA SRSHDHFGHE NWDHQLKLAV AWNRVDIARS EIFTDERQWK
PSELHPMMTA ALISNKPEFV KLFLENGVRL KEFVTWDTLL YLYKNLDPSC LFHCKLQKVL
AEEPERMACA PSAPRVQMHH VAQVLRELLG DSTQLLYPRP QTSDRPRLTL PVPHIKLNVQ
GVSLRSLYKH SSGHVAFTMD PVRDLLIWAI VQNRRELAEI IWDQSQDCIA AALACTKILK
ELSKEEQDTD SSEEMLALAD EYEHRAIGVF TECYRKDEER AQKLLIRVSE AWGKTTCLQL
ALEAKDMKFV SHGGIQAFLT KVWWGHLCVD NGLWRVILCM LAFPLLYTDL ISFRERRLQA
MRGLPRIRAF FTAPVVIFHL NILWYFVFLC LFAYVLMVDF QTTPSCCEYL IYFWLFSLVC
EELRQLFYDP AGCGLRKTVF VYFSDFWNKL DIAAILLFIA GLTCRLIPAS LYSGRVILSL
DFIMFCLRLM HIFTISKTLG PKIIIMKRMM KDVFFFLFLL AVWVVSFGVA KQAILIHNES
RVDWIFRGVV YQSYLTIFGE IPAYIDGVNF SLDHCSPNGT DPYKPKCPES DATRQAPAFP
QWLTVILLCL YLLFANILLL NLLIAMFNYT FQQVQEHTDQ IWKFQRHDLI EEYHSRPPAP
PPFILLSHLH LCIRRVVLKI PAKRHKQLKN KLEKNEEAAL LAWEIYLKEN YLQNQQCQRT
QRPEQKIQDI SNKVDTMVDL LEMERVKRSG SMEQRLASLE EQVAQMAGAL HWMVKTLRDG
GFGLEEGLPT LAPQKASEGQ DPELDGRQKA EDPGDAHHVN ARHLLYPSSR VMRFPVPNEK
VPWETEFLIY DPPFYTAERK DEDMVDPVGS TLEPLSGISY NALDGPVDRR SSHGPYAVQD
GLPRNPMGRT GLWGRGDLTY FGPNHTLQPV VTRWRRNQDG AICRKSIKKM LEVLVVKRPL
SEHWALPGGS REPGETLPRK LKQVLRREFW PSFESLLTQG VEVYKGYVDD PRNTDNAWIE
TVAVSIHFPD QSDVELKRLN SHLQPCDPGM SVRWQVVDKC IPLYANHKTI LQKTGKGLLP
GRCMMWFGDL PSLTPAGVAG QTSS
//