ID F6YFH0_ORNAN Unreviewed; 527 AA.
AC F6YFH0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Tudor and KH domain containing {ECO:0000313|Ensembl:ENSOANP00000001738.2};
GN Name=TDRKH {ECO:0000313|Ensembl:ENSOANP00000001738.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000001738.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000001738.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000001738.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000001738.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000001738.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YFH0; -.
DR STRING; 9258.ENSOANP00000001738; -.
DR Ensembl; ENSOANT00000001739.3; ENSOANP00000001738.2; ENSOANG00000001094.3.
DR eggNOG; KOG2279; Eukaryota.
DR GeneTree; ENSGT00940000159364; -.
DR HOGENOM; CLU_761951_0_0_1; -.
DR Proteomes; UP000002279; Chromosome X5.
DR Bgee; ENSOANG00000001094; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22428; KH-I_TDRKH_rpt1; 1.
DR CDD; cd20412; Tudor_TDRD2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR047382; KH-I_TDRKH_rpt1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR047380; TDRD2-like_tudor.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR22948:SF18; TUDOR AND KH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..391
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 214..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..269
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 57376 MW; C33BC1F65341D823 CRC64;
MAAGRSWWQS LATGQKVALA LGVPAGITVG YILYRRFRES REERVTFVGD DDMEVEVRVP
QEALKLIIGR QGANIKKLRK ETGARINVDM EGAGEERVLL ISGFPVQVCK AEAAVHRLLR
EHAQVHEQIS VPQRSIGKII GRGGETIRSI CKSSGARISC DREAEGALLL TRFINLSGSQ
KEVDTAKSLI REKVQEDEVL RHHIAHSAEL RVQRKQPVGV RREAAGAGES VTPREPEDRW
KAALRGGGGD EADPPVEGPP KPGPDKSPKF EVPSPDLSFP ADELLEVYVS ASENPGHFWI
QILGPRSLRL DQLVADMTRH YRGSCPPDAA QPVCVGDIVA APLPEDGPWY RARVLGPLDS
GKMDLYFVDF GDNGESPVED LRPLRSDFLS LPFQAIECSL AGVAPAGGQW EEAALDEFER
LTHCADWKPL VARISSYVQA GTTTWPAVHL FDLNEGQNLD IGLELVRRGY AVKVPQEPEV
PEPLAPEADA SEESPGSGSW KTPAATPHSL SCHSLSEAAS PLDDDVA
//
