ID F6YFV7_HORSE Unreviewed; 472 AA.
AC F6YFV7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Interferon gamma receptor 1 {ECO:0000313|Ensembl:ENSECAP00000007472.2};
GN Name=IFNGR1 {ECO:0000313|Ensembl:ENSECAP00000007472.2,
GN ECO:0000313|VGNC:VGNC:18952};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007472.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007472.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007472.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007472.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007472.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC {ECO:0000256|ARBA:ARBA00005399}.
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DR AlphaFoldDB; F6YFV7; -.
DR SMR; F6YFV7; -.
DR STRING; 9796.ENSECAP00000007472; -.
DR PaxDb; 9796-ENSECAP00000007472; -.
DR Ensembl; ENSECAT00000009767.4; ENSECAP00000007472.2; ENSECAG00000009347.4.
DR VGNC; VGNC:18952; IFNGR1.
DR GeneTree; ENSGT00510000048929; -.
DR HOGENOM; CLU_043814_0_0_1; -.
DR InParanoid; F6YFV7; -.
DR OMA; NIMLPKS; -.
DR OrthoDB; 5356432at2759; -.
DR TreeFam; TF338358; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000009347; Expressed in leukocyte and 23 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019955; F:cytokine binding; IEA:InterPro.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0004906; F:type II interferon receptor activity; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0038196; P:type III interferon-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR021126; IFN_gamma_rc_D2_pox/mammal.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008355; Interferon_gamma_rcpt_asu.
DR PANTHER; PTHR20859:SF5; INTERFERON GAMMA RECEPTOR 1; 1.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR Pfam; PF07140; IFNGR1_D2; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR PRINTS; PR01777; INTERFERONGR.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..472
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018725139"
FT TRANSMEM 247..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..110
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 130..238
FT /note="Interferon gamma receptor D2"
FT /evidence="ECO:0000259|Pfam:PF07140"
FT REGION 323..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 51914 MW; 56334E94B7FE4C1F CRC64;
MAPLLVLLLV VLQRAGSRAE MGAADLEPPL VPPPTRVRIE AYNVNTILSW DYPTVPQAPV
FTAQVKTYGN AWIDACNTSY HRCNISSKIN DPTRPLWARV KARLGQEESA YADSKEFILC
QHGKIGPPKL DIRKKDDQII IDISHPLFAV NGFDLEAMYD DENACYEFVY KVYVKINGSG
ESMERVYECR DEDCNETHCR LGIPASSLNS QCCAAAEGVS ERWEFTTDKS EELCLTVFDD
GSPEGSVWIP VVAAFLLFLV ILLVACCYCR IKTKNLFKRR NNPLPSSLLS VVRSASSEPD
SESKHISPVT YQPIVPENDH LSSAAVSGTQ AEDSPRGGHR AELSRETDVL TTEGALSDVA
PGRPLTPVRR ESSVHSGSNQ SEPCSVLLNS YHSRNGSDSG VVESDSFLSD SEFPPNNKTE
IKTEGPESTT LRNTAVSFGY DKPHVLVDLL VDEGGKESLI GYRLTADSQE FS
//
