ID F6YH99_HORSE Unreviewed; 951 AA.
AC F6YH99;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=PHD finger protein 12 {ECO:0000313|Ensembl:ENSECAP00000014364.3};
GN Name=PHF12 {ECO:0000313|VGNC:VGNC:21375};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014364.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000014364.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014364.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000014364.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014364.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YH99; -.
DR Ensembl; ENSECAT00000017670.4; ENSECAP00000014364.3; ENSECAG00000016493.4.
DR VGNC; VGNC:21375; PHF12.
DR GeneTree; ENSGT00940000155713; -.
DR HOGENOM; CLU_015009_0_0_1; -.
DR TreeFam; TF336193; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000016493; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; F6YH99; baseline.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd22703; FHA_PHF12; 1.
DR CDD; cd15533; PHD1_PHF12; 1.
DR CDD; cd15534; PHD2_PHF12_Rco1; 1.
DR Gene3D; 6.10.20.60; PHD finger protein 12; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR031966; PHF12_MRG-bd.
DR InterPro; IPR038098; PHF12_MRG-bd_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46309; PHD FINGER PROTEIN 12; 1.
DR PANTHER; PTHR46309:SF1; PHD FINGER PROTEIN 12; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF16737; PHF12_MRG_bd; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 36..85
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 251..301
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 759..816
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 103579 MW; 707E20861BB785F7 CRC64;
MEQIQALLAP PKTDEAEKRS RKPEKEPRRS GRATNHDSCD SCKEGGDLLC CDHCPAAFHL
QCCNPPLSEE MLPPGEWMCH RCTVRRKKRE QKKELGHVNG LVDKSGKRTT SPSSDTDLLD
RSASKTELKA IAHARILERR ASRPGTPTSN ASTETPTSEQ NDVDEDIIDV DEEPAAAESD
YVQPQLRRPF ELLIAAAMER NPTQFQLPNE LTCTTALPGS SKRRRKEETT GKNVKKTQHE
LDHNGLVPLP VKVCFTCNRS CRVAPLIQCD YCPLLFHMDC LEPPLTAMPL GRWMCPNHIE
HVVLNQKNMT LSNRCQVFDR FQDTISQHVV KVDFLNRIHK KHPPNRRVLQ SVKRRSLKVP
DAIKSQYQFP PPLIAPAAIR DGELICNGIP EESQTHLLNS EHLATQAEQQ EWLCSVVALQ
CSILKHLSAK QMPSHWDSEQ TEKADIKPVI VTDSSITTSL QTADKAPIPS HYPLSCPSGI
STQNSLSCSP PPQPPALEDI SCSSCAEKSK KAPCGTANGP VNTEVKANGP HLYSSPTDST
DPRRLPGANT PLPGLSHRQG WPRPLTPPAA GGLQNHTVGI IVKTENATGP SSCPQRSLVP
VPSLPPSIPS SCASIENTST LQRKTVQSQI GPPLTDSRPL GSPPNATRVL TPPQAAGDGI
LAPGANQRFC SPAPSSDGKV SPGTLSIGSA LTVPSFPANS TAMVDLTNSL RAFMDVNGEI
EINMLDEKLI KFLALQRIHQ LFPSRVQASP GSVGAHQLAS GGHHTEGADM DVCLTNYGHC
NYVSGKHACI FYDENTKHYE LLNYSEHGTT VDNVLYSCDF SEKTPPTPPS SIVAKVQSVI
RRRRHQKQDE EPSEEAVMMS SQAQGPQRRP CNCKASSSSL IGGSGAGWEG TALLHHGSYI
KLGCLQFVFS ITEFATKQPK GDAGLLQDAV LAEKLSLKPH QGPVLRSNSV P
//
