ID F6YJR2_ORNAN Unreviewed; 889 AA.
AC F6YJR2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Leucine rich repeats and guanylate kinase domain containing {ECO:0000313|Ensembl:ENSOANP00000018191.3};
GN Name=LRGUK {ECO:0000313|Ensembl:ENSOANP00000018191.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000018191.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000018191.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018191.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000018191.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018191.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YJR2; -.
DR STRING; 9258.ENSOANP00000018191; -.
DR Ensembl; ENSOANT00000018194.3; ENSOANP00000018191.3; ENSOANG00000011480.3.
DR eggNOG; KOG0531; Eukaryota.
DR eggNOG; KOG0707; Eukaryota.
DR GeneTree; ENSGT00940000157992; -.
DR HOGENOM; CLU_019293_1_0_1; -.
DR InParanoid; F6YJR2; -.
DR OMA; XSNNQIE; -.
DR TreeFam; TF329158; -.
DR Proteomes; UP000002279; Chromosome 10.
DR Bgee; ENSOANG00000011480; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004385; F:guanylate kinase activity; IBA:GO_Central.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 440..623
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..119
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 99067 MW; F494F467DCA08A1A CRC64;
MSYSHSRNPS RRPRLPGDGG VPSPGRRRLP VSRATAGTPG PLGAMWWASG RAGRPPDDGD
AMSVSLLCPA GPRLRSGGSA SVLRPRGSAQ SARLWEAEPE LEEEEEEEEE EESSSESEEE
MPAIEEHFDG ILREDAVAEA LHKLGRSAQG TEQVYLNLSL SACDLSDISI LCGYVHLEKL
ELSFNKINDL TCVSYMPYLL ELNASHNELT SFFNFKPPKN LKKVDLSHNS IPEMKDLSSY
QALTTLILDN NNIQEIKGLE QCMNLIHLSL AHNKIITIDG LNKLPIKILC LSFNQIETIT
GLEDLKTLRN LDLSHNKILS LRGLENHKYL EIINLEDNQI AELGELEYID DLPLLRVLNL
LKNPVQENSE YWLLVLFMLL RLTELDGKKI EVKEKVAAVN KYDPPPEVIA ARDHLTHVVH
SMMQPQKIFD STLPSLDAPY PMLVLVGPQD CGKRELAQRL CRQFSAFFRY GACHTTRPPY
FGEGDRVDYH FISQEIFHEM LSMGKFIVTF KYSNHNYGLN RDTVEGIARD GLASCIHMEI
EGVRSLKNTY FEPRYVLLVP LNKERYEGYL RRKGVFSRAE VEFAVSRVDY YVKINQDFPG
YFDAIINADD LDDAYQKLSQ LIREYLSLAE NDKDLTLSEN KATTIADFRT EPSDLSPARI
GEFYMSNTQP PIINEILDST GRNYSAKLSA KLSADPTPVE FSMQRRHEAA RQAIMGKMSF
TFTHLLQSKL VPTPDPSKPH LDTMKQLSFQ LPRIGGSFIP GNSLNPAGSD TSGSSLDRSF
SPLWMAGPSA PSFDGSCVGQ AGALGVGSGV HRPQSLTPFS SHTVSTIQGQ ASNDNSRKMK
QALSPALPDK RLNMMRSNIS RPSQNIVRPG SNTKPVLPPI PQGHKAGGS
//
