ID F6YRS5_CALJA Unreviewed; 855 AA.
AC F6YRS5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSCJAP00000010383.6};
GN Name=RALGDS {ECO:0000313|Ensembl:ENSCJAP00000010383.6};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000010383.6, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000010383.6}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000010383.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YRS5; -.
DR Ensembl; ENSCJAT00000010973.6; ENSCJAP00000010383.6; ENSCJAG00000018000.6.
DR GeneTree; ENSGT00940000153181; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000018000; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17209; RA_RalGDS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR015758; RalGDS_RA.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 42..179
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 328..589
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 739..826
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 182..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..254
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..308
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 93674 MW; 2BB22170667306AF CRC64;
HLSDFIYSIS LRKVQLHHGA NKGQRWLGYE NESALNLYET CKVRTVKAGT LEKLVEHLVP
AFQGSDLSYV TIFLCTYRAF TTTQQVLDLL FKRYGRCDAL TASSRYGCIL PYSDEDGGPQ
DQLKNAISSI LGTWLDQYSE DFCQPPDFPC LKQLVAYVQL NMPGSDLERR AHLLLAQLEH
SEPTEAEPEA LSPVPALKPA PAPARAPSPA PAPVLEPAPT PAPASELEPA PAPAPAPAPA
PSPAPAPAPA PTSELEVAPA PAQELPRAPA PEREPALPAE RDPTPSQTPE LEPALAPVPS
PEPSWPSPVP VVAENGLSEE KPHLLVFPPD LVAEQFTLMD AELFKKVVPY HCLGSIWSQR
DKKGKEHLAP TIRATVTQFN SVANCVITTC LGDRSTKAPD RARVVEHWIE VARECRVLKN
FSSLYAILSA LQSNSIHRLK KTWEEVSRDS FRIFQKLSEI FSDENNYSLS RELLIKEGTS
KFATLEMNPK RAQKRPKETG IIQGTVPYLG TFLTDLVMLD TAMKDYLYRL SSALLWPQEF
EVIAQIKLLQ SACNNYSIAP DEQFGAWFRA VERLSEAESY NLSCELEPPS ESASNTLKTK
KNAAIVKRWS DRQAPSTELS TSGSSHSKSC DQLRCGPYLS SGDIADALSV HSAGSSSSDV
EEINISFVPE SPDGQEKKFW ESASQSSPET SGISSASSST SSSSASTTPV AATRTHKRSV
SGLCSSTSAL PLYNQQVGDC CIIRVSLDVD NGNMYKSILV TSQDKAPAVI RKAMDKHHLD
ADEPEDYELV QILSDERKLK IPENANVFYA MNSTANYDFV LKKRTFTKGV KVKHGASSTL
PRMKQKGLKI AKGIF
//
