ID F6YVG5_HORSE Unreviewed; 876 AA.
AC F6YVG5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Aminoadipate-semialdehyde dehydrogenase {ECO:0000313|Ensembl:ENSECAP00000007687.2};
GN Name=AASDH {ECO:0000313|Ensembl:ENSECAP00000007687.2,
GN ECO:0000313|VGNC:VGNC:14893};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007687.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007687.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007687.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007687.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007687.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YVG5; -.
DR Ensembl; ENSECAT00000010008.3; ENSECAP00000007687.2; ENSECAG00000009502.4.
DR VGNC; VGNC:14893; AASDH.
DR GeneTree; ENSGT00440000033811; -.
DR HOGENOM; CLU_010423_0_0_1; -.
DR TreeFam; TF314245; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000009502; Expressed in gluteus medius and 23 other cell types or tissues.
DR ExpressionAtlas; F6YVG5; baseline.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd17654; A_NRPS_acs4; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR048005; AASDH_AMP.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR44394; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44394:SF1; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR Pfam; PF13570; PQQ_3; 1.
DR SMART; SM00564; PQQ; 6.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 331..408
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 876 AA; 97141 MW; 74DBD0CB1E87724F CRC64;
MVLFEITQDD VLFLASPLTF DPSVVEIFVA LSSGASLLIV PTSVKVIPSK LAAVLFSHHR
VTVLQATPTL LRRFGSQLIK STVLSTSTSL RVLALGGEAF PSLTVLKSWR GVGNKTQIFN
IYGITEVSSW ATFYRIPEKT LNSTLKCELP VQLGFPLLGT VVEVRDTDGF AIQEGDGQVF
LGGRNRVCFL DDEVTVPLGT MRATGDFVTV KDGEIFFLGR KDSQIKRHGK RLNIELVQQV
AEGLQEVESC AVTWYNQEKL ILFMVSKNDL VKDYIFEELQ KHLPSHAIPD ELVLIDSLPF
TSHGKIDVSE LNKIYLNYIN LKSECKLNGK EELWEKLQHL WKSILSLSED PLRIPDESLF
LNSGGDSLKS IRLLNEIEKL VGTSVPGLLE IILNSSILEI YNHIVQTVFP DEDLTFSKNY
ATKRKFSDIN QETSGKSLHQ NSVMPLNCDK KINAFIALSR GGQILSVNTT RPLTKLGHCP
SACSSDLISQ TNTQNVESLN PPALSGKSKD PSCVAEFFSE EGTPVIEAEK MELCVRWMSD
TGKCVDASPL VVIPAVDKSS ATVYIGSHSH RMMAVDLYSG KVKWEQILGD RVESSACVSK
CGNFIVVGCY NGLVYVLKSS SGEKYWTFTT EDAVKSSATM DPTTGLLYIG SHDQHAYALD
IYKKKCVWKL KCGATVFSSP CLSLTPHHLY FATLGGLLLA VNPATGNRIW KHSCGKPLFS
SPRCCLQYIC IGCVDGNLLC FTHFGEQVWQ FCTSEPIFSS PCTSASEQEI FFGSHDCFIY
CCNTKGHLQW KFETTSRVYS TPFNFHNYNR SDEMLLAAAS TDGKLWILES KSGQLQSVYR
LPGEVFSSPV VWESMLIIGC RNNYVYCLDL LGGNQK
//
