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Database: UniProt
Entry: F6YWY4_HORSE
LinkDB: F6YWY4_HORSE
Original site: F6YWY4_HORSE 
ID   F6YWY4_HORSE            Unreviewed;      2174 AA.
AC   F6YWY4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 46.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSECAP00000014581};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014581, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000014581, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014581,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000014581}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014581};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000014581}.
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DR   STRING; 9796.ENSECAP00000014581; -.
DR   PaxDb; F6YWY4; -.
DR   Ensembl; ENSECAT00000017909; ENSECAP00000014581; ENSECAG00000015461.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F6YWY4; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000002281; Chromosome 11.
DR   Bgee; ENSECAG00000015461; -.
DR   ExpressionAtlas; F6YWY4; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF256; PTHR10037:SF256; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    214    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    369    394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    744    762       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    774    795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    865    884       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    941    964       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1277   1295       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1315   1336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1348   1367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1412   1434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1514   1537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1612   1633       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1645   1668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1746   1765       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1828   1850       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    405       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      743    969       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1275   1547       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1611   1860       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1546   1573       {ECO:0000256|SAM:Coils}.
FT   COILED     1849   1873       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2174 AA;  240799 MW;  F6471D0D2D32EE93 CRC64;
     GREEDGAGAE ESGQPRSFMR LNDLSGAGGR PGPGSAEKDP GSADSEAEGL PYPALAPVVF
     FYLSQDSRPR SWCLRTVCNP YPPGRISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF
     DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR
     TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR
     CFLPENFTLP LSVDLERYYQ TENEDENPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL
     DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM
     YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA
     STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RAGLLSSPAP RGGPEPQPSG
     SCSRSHRRPS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP
     ALSGGPPGGT ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE
     MLKDKALVEV APTSGPPTLT SLNIPPGPYS SMHKLLETHS TGTCQRSCKI SSPCLKADSG
     ACGPDSCPYC ARAGAGEVEL AGHEMPDSDS EAVYEFTQEA QHGDLRDPHS RRRRNLGLDV
     EPNSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI
     VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR
     VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
     PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV
     AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDATKSE SEPDFFSPSL DGNGDRKKHL
     ALVSLGEHLE LPRSLLPPLI IHTAATPMSL PKSSSTGLAE ALGPASRRTS SSGSGEPGTA
     QEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRASSLK RRSPSGERRS LLSGEGRESQ
     DEEDSSEEEQ ASPAGGHCRH GGSLEREAKS SFDLPDTLQV PGLHRTATGR STASEHQDCN
     GKSAPGRLAR ALLPDDPPLD GDDGDDEGNL SKAERLRAWI RARLPACCRE RDSWSAYIFP
     PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV
     FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISIID ILVSMVSDSG TKILGMLRVL
     RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV
     CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG
     VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL
     RRLEKKRRNL MLDDVIASGS SASAAPEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV
     IGLNVITMAM EHYRQPQVLD EALKVCNYVF TVIFVLESVL KLVAFGFRRF FQDRWNQLDL
     AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL
     PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHAFRNFGMA FLTLFRVSTG
     DNWNGIMKDT LRDCDQESTC YNTVISPIYF VSFVLTAQFV LVNVVIAVLM KHLEESNKEA
     KEEAELEAEL ELEMKTLSPQ PHSPLGSPFF WPGGPESPDS PKSGALHATA HAGAASRLSL
     EHSTDRQLFD TISLLIQGSL EGELKLMDEL AGPGGQPSAF PPARSPGGSD PQIPLAEMEA
     LSLTSEIVSE PSCSLALTDD SLPDDTHTLL LSAPESNMER HPEEVPLSMG PDLLTVRKSG
     VSRTHSLPND SYMCRDGSTA KGSLGHRGWG LPKAQSGSVL SVHSQPADTS YILQVPKDAP
     HLLQPHSTPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE DLLSEVSGPS
     PLARAPLFWG RLST
//
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