ID F6YXA5_HORSE Unreviewed; 970 AA.
AC F6YXA5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Striatin 4 {ECO:0000313|Ensembl:ENSECAP00000002594.3};
GN Name=STRN4 {ECO:0000313|VGNC:VGNC:23721};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002594.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002594.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002594.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002594.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002594.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat striatin family.
CC {ECO:0000256|ARBA:ARBA00009616}.
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DR AlphaFoldDB; F6YXA5; -.
DR STRING; 9796.ENSECAP00000002594; -.
DR PaxDb; 9796-ENSECAP00000002594; -.
DR Ensembl; ENSECAT00000003709.3; ENSECAP00000002594.3; ENSECAG00000002830.3.
DR VGNC; VGNC:23721; STRN4.
DR GeneTree; ENSGT00950000183095; -.
DR HOGENOM; CLU_009108_2_0_1; -.
DR InParanoid; F6YXA5; -.
DR OMA; GKAVHSM; -.
DR TreeFam; TF313387; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000002830; Expressed in synovial membrane of synovial joint and 23 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IEA:Ensembl.
DR GO; GO:0070016; F:armadillo repeat domain binding; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013258; Striatin_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15653; STRIATIN; 1.
DR PANTHER; PTHR15653:SF1; STRIATIN-4; 1.
DR Pfam; PF08232; Striatin; 2.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 255..285
FT /note="Striatin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08232"
FT DOMAIN 311..409
FT /note="Striatin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08232"
FT REPEAT 651..692
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 704..737
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 757..789
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 892..933
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 93..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 102869 MW; E929AC81F1A2BF49 CRC64;
MRGGAGGPPG TWVTLATSSW RRYRRGLGLQ NHRGGGEGRL GAFQAPGQES ERMGLLLNPL
PTVSPFLSKR DGRGEWDWGL ERVRVFLWGE ERGGGQEAGP SEVPLFPGAT LARGPGRASP
SCPFPPPSQR AHAPSGSTRV GEARARPRPR ARPPQAPGGR AQGGGGGWRG RAGARGTAGA
RAGPGASMME ERAAAAVAAA AASCRPLGSG AGPGPTGAAP APAPSPGPGP AGKGGGGGGG
GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQESAGDG EGVGDCESSA
IAGTPAPGPH QAQVAFLQGE RKGQENLKTD LVRRIKMLEY ALKQERAKYH KLKFGTDLNQ
GEKKPELSEQ VSNGPVESVT LENSPLVWKE GRQLLRQYLE EVGYTDTILD MRSKRVRSLL
GRSLELNGAV EPSEGGPRAT PGPGGLSGGE SLLVKQIEEQ IKRNAAGKDS KERLGGSVLE
QIPFLQNCED EDSDEDDELD SVQHKKQRVK LPSKALVPEM EDEDEEDDSE DAINEFDFLG
SGEDGDGSPD PRRCPGEGTH HELESRRVKL QGILADLRDV DGLPPKVTGP PPGTPQPRPH
EDVFIMDTIG GGEVSLGDLA DLTVTNDNDL SCDLSGSTDA LKKTWNPRFT LRSHYDGIRS
LAFHHRQSAL LTASEDGTLK LWNLQKAATA RKNAALDVEP IHAFRAHRGP VLAVAVGSNS
EYCYSGGADA RIHSWKIPDL NMDPYDGYDP SVLSHVLEGH GDAVWGLAFS PTAQRLASCS
ADGTVRIWDP SSSSPTCLCT FPMTSDHGIP TSVAFTSTEP AHIVASFRSG DTVLYDLEAG
SALLTLESRG SSSLTQINQV VSHPSQPLTI TAHDDRGIRF LDNRTGKCVH SMVAHLDAVT
CLAVDPNGVF LMSGSHDCSL RLWSLDNKTC VQEITAHRKK HEEAIHAVAC HPSKALIASA
GADALAKVFV
//
