ID F6YZV1_HORSE Unreviewed; 1521 AA.
AC F6YZV1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 2 {ECO:0000313|Ensembl:ENSECAP00000019730.3};
GN Name=SHANK2 {ECO:0000313|Ensembl:ENSECAP00000019730.3,
GN ECO:0000313|VGNC:VGNC:22952};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019730.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000019730.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019730.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000019730.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019730.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR AlphaFoldDB; F6YZV1; -.
DR Ensembl; ENSECAT00000023789.4; ENSECAP00000019730.3; ENSECAG00000022208.5.
DR VGNC; VGNC:22952; SHANK2.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000022208; Expressed in oviduct epithelium and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR CDD; cd11983; SH3_Shank2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF17; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 199..258
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 299..393
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1458..1521
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..576
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..963
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1521 AA; 164365 MW; 79FF3F490BD34C4A CRC64;
MPSDARKLAV PRRPPPLPGS TPLQRRGAGQ RPLPSSHPRR LYNERTTAKV GGKMKSLLNA
FTKKEVPFRE APAYSNRRRR PPNTLAAPRV LLRSNSDNNL NASTPEWAVC SAASHRSLSP
QLLQQLPSKP DGAVKTIGSY TPGPRSRSPS LNRLGGAGED GKRLQQPWHI GPTFPPGAHK
DVLSAFEYPG PKRKLYSAVP GRLFVVVKPY QPQVDGEIPL HRGDRVKVLS IGEGGFWEGS
ARGHIGWFPA ECVEEVQCKP KDIQAETRAD RSKKLFRHYT VGSYDSFDAS SDCIIEEKTV
VLQKKDNEGF GFVLRGAKAD TPIEEFTPTP AFPALQYLES VDEGGVAWQA GLRTGDFLIE
VNNENVVKVG HRQVVSMIRQ GGNHLVLKVV TVTRNLDPDD TARKKAPPPP KRAPTTALTL
RSKSMTSELE ELASVRKKKD KPDEIVPASK PSRTVENVAV ESRVATIKQR PTSRCFPSVS
DMNSVYERQG IAVMTPTVPG SPKGPFLGLP RGTMRRQKSI DSRIFLSGIT EEERQFLAPP
MLKFTRSLSM PDTSEDIPPP PQSIPPSPPP PSPTAYNCPK SPTPRVYGTI KPAFNQNSAA
KVLPAARSDT VATMMRDKGL YYRRELDRYS LDSEDLYSRN AAAQANFRNK RGQMPENPYS
EVGKIASKAV YVPAKPARRK GMLVKQSNVE DSPEKTCSIP IPTIIVKEPS TSSSGKSSQG
SSMEIDPQAS EQPGQLRPDD GLAVSSPFAA AIAGAVRDRE KRLEARRNSP AFLSTDLGDE
DVGLGLPAPR MLPSNFPEEG GFGEEDGAEQ LSPPTSGAVP REPENHFVGV GEAGAQGEAG
RPLNSTSKAK GPESSPTVPP KSSNAAGPEN YVHPLTGRLL DPSSPLALAL SARDRAMKES
QQGPKGEAPK ADLNKPLYID TKMRPSVEAG FPTVTRQNTR GPLRRQETEN KYETELGKDR
KGDDKKNMLI DIVDTSQQKS AGLLMVHTVD AARSDDFLEE EDEKADMETK PDSSPTEVPE
GVPETEGALQ ISAGPEPANA AAPGRTIVAV GSMEEAVILP FRIPPPPLAS VDLDEEFIFT
EPLPPPLEFA NSFDIPDDRV ASVPALTDLV KQKKNDASQP PSLNSSQPTN SADSKKPAGL
SNCLPASFLP PPESFDTVTD SGIEEVDSRS SSDHHLETTS TISTVSSIST LSSEGGENVD
TCTVYADGQA FMVDKPPVPP KPKMKPVIHK SNALYQDALV EEDADSFVIP PPAPPPPPGG
VQPGTIKVIQ PRTSKLWGDV SEIKSPILSG PKANVISELN SILQQMNREK SAKPGEGLDL
PTGTKPASLA PRSPEVMSTI SGTRSTTVTF TVRPGTSQPI TLQSRPPDYE SRTSGTRRAP
SPVVSPTEMN KETLPAPLCA AAASPSPALS DVFSLPGQPP SGDLFGLNPA GRSRSPSPSI
LQQPISNKPF TTKPVHLWTK PDVADWLESL NLGEHKETFM DNEIDGSHLP NLQKEDLIDL
GVTRVGHRMN IERALKQLLD R
//
