ID F6YZZ8_MOUSE Unreviewed; 870 AA.
AC F6YZZ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor {ECO:0000313|Ensembl:ENSMUSP00000102342.4};
GN Name=Lrp8 {ECO:0000313|Ensembl:ENSMUSP00000102342.4,
GN ECO:0000313|MGI:MGI:1340044};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000102342.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000102342.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102342.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000102342.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102342.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; NP_001074395.1; NM_001080926.1.
DR AlphaFoldDB; F6YZZ8; -.
DR SMR; F6YZZ8; -.
DR MaxQB; F6YZZ8; -.
DR PaxDb; 10090-ENSMUSP00000102343; -.
DR PeptideAtlas; F6YZZ8; -.
DR ProteomicsDB; 322653; -.
DR Antibodypedia; 33078; 467 antibodies from 33 providers.
DR DNASU; 16975; -.
DR Ensembl; ENSMUST00000106731.4; ENSMUSP00000102342.4; ENSMUSG00000028613.16.
DR GeneID; 16975; -.
DR KEGG; mmu:16975; -.
DR UCSC; uc008uag.1; mouse.
DR AGR; MGI:1340044; -.
DR CTD; 7804; -.
DR MGI; MGI:1340044; Lrp8.
DR VEuPathDB; HostDB:ENSMUSG00000028613; -.
DR GeneTree; ENSGT00940000154819; -.
DR HOGENOM; CLU_008163_2_0_1; -.
DR OrthoDB; 3918101at2759; -.
DR ChiTaRS; Lrp8; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000028613; Expressed in embryonic brain and 171 other cell types or tissues.
DR ExpressionAtlas; F6YZZ8; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS51120; LDLRB; 4.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:F6YZZ8,
KW ECO:0007829|MaxQB:F6YZZ8}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..870
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021852363"
FT TRANSMEM 732..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 283..322
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 369..415
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 416..458
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 459..502
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 503..547
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 652..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 41..53
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 48..66
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 60..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 80..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 87..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 142..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 165..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 172..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 184..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 213..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 287..297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 870 AA; 96319 MW; 9DA73B3398D42377 CRC64;
MGRPELGALR PLALLLLLLL QLQHLSAADP LPGGQGPVKE CEEDQFRCRN ERCIPLVWRC
DEDNDCSDNS DEDDCPKRTC ADSDFTCDNG HCIPERWKCD GEEECPDGSD ESKATCSSEE
CPAEKLSCGP TSHKCVPASW RCDGEKDCEG GADEAGCPTS APGPCRENEF QCGDGTCVLA
IKRCNQERDC PDGSDEAGCL QESTCEGPRR FQCKSGECVD GGKVCDDQRD CRDWSDEPQK
VCGLNECLHN NGGCSHICTD LKIGFECTCP AGFQLLDQKT CGDIDECQDP DACSQICVNY
KGYFKCECHP GYEMDTLTKN CKAVAGKSPS LIFTNRHEVR RIDLVKRDYS RLIPMLKNVV
ALDVEVATNR IYWCDLSYRK IYSAHMDKAS IPDEQVVLID EQLHSPEGLA VDWVHKHIYW
TDSGNKTISV ATTDGRRRCT LFSRELSEPR AIAVDPLRGF MYWSDWGFQA KIEKAGLNGA
DRQTLVSDNI EWPNGITLDL LSQRLYWVDS KLHQLSSIDF NGGNRKMLIF STDFLSHPFG
VAVFEDKVFW TDLENEAIFS ANRLNGLEIA ILAENLNNPH DIVIFHELKQ PKAADACDLS
AQPNGGCEYL CLPAPQISSH SPKYTCACPD TMWLGPDMKR CYRAPQSTST TTLASAMTRT
VPATTRAPGT TIHDPTYQNH STETPSQTAA APHSVNVPRA PSTSPSTPSP ATSNHSQHYG
NEGSQMGSTV TAAVIGVIVP IVVIALLCMS GYLIWRNWKR KNTKSMNFDN PVYRKTTEEE
EEDELHIGRT AQIGHVYPAA ISNYDRPLWA EPCLGETRDL EDPAPALKEL FVLPGEPRSQ
LHQLPKNPLS ELPVVKCKRV ALSLEDDGLP
//