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Database: UniProt
Entry: F6YZZ8_MOUSE
LinkDB: F6YZZ8_MOUSE
Original site: F6YZZ8_MOUSE 
ID   F6YZZ8_MOUSE            Unreviewed;       870 AA.
AC   F6YZZ8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2019, sequence version 2.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor {ECO:0000313|Ensembl:ENSMUSP00000102342.4};
GN   Name=Lrp8 {ECO:0000313|Ensembl:ENSMUSP00000102342.4,
GN   ECO:0000313|MGI:MGI:1340044};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000102342.4, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000102342.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102342.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000102342.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102342.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   RefSeq; NP_001074395.1; NM_001080926.1.
DR   AlphaFoldDB; F6YZZ8; -.
DR   SMR; F6YZZ8; -.
DR   MaxQB; F6YZZ8; -.
DR   PaxDb; 10090-ENSMUSP00000102343; -.
DR   PeptideAtlas; F6YZZ8; -.
DR   ProteomicsDB; 322653; -.
DR   Antibodypedia; 33078; 467 antibodies from 33 providers.
DR   DNASU; 16975; -.
DR   Ensembl; ENSMUST00000106731.4; ENSMUSP00000102342.4; ENSMUSG00000028613.16.
DR   GeneID; 16975; -.
DR   KEGG; mmu:16975; -.
DR   UCSC; uc008uag.1; mouse.
DR   AGR; MGI:1340044; -.
DR   CTD; 7804; -.
DR   MGI; MGI:1340044; Lrp8.
DR   VEuPathDB; HostDB:ENSMUSG00000028613; -.
DR   GeneTree; ENSGT00940000154819; -.
DR   HOGENOM; CLU_008163_2_0_1; -.
DR   OrthoDB; 3918101at2759; -.
DR   ChiTaRS; Lrp8; mouse.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000028613; Expressed in embryonic brain and 171 other cell types or tissues.
DR   ExpressionAtlas; F6YZZ8; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR   CDD; cd00054; EGF_CA; 1.
DR   CDD; cd00112; LDLa; 5.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF14670; FXa_inhibition; 1.
DR   Pfam; PF00057; Ldl_recept_a; 5.
DR   Pfam; PF00058; Ldl_recept_b; 5.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00192; LDLa; 5.
DR   SMART; SM00135; LY; 5.
DR   SUPFAM; SSF57196; EGF/Laminin; 3.
DR   SUPFAM; SSF57424; LDL receptor-like module; 5.
DR   SUPFAM; SSF63825; YWTD domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS01209; LDLRA_1; 3.
DR   PROSITE; PS50068; LDLRA_2; 5.
DR   PROSITE; PS51120; LDLRB; 4.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:F6YZZ8,
KW   ECO:0007829|MaxQB:F6YZZ8}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..870
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5021852363"
FT   TRANSMEM        732..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          283..322
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REPEAT          369..415
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          416..458
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          459..502
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          503..547
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REGION          652..725
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        41..53
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        48..66
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        60..75
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        80..92
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        87..105
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        142..157
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        165..177
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        172..190
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        184..199
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        213..231
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        287..297
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   870 AA;  96319 MW;  9DA73B3398D42377 CRC64;
     MGRPELGALR PLALLLLLLL QLQHLSAADP LPGGQGPVKE CEEDQFRCRN ERCIPLVWRC
     DEDNDCSDNS DEDDCPKRTC ADSDFTCDNG HCIPERWKCD GEEECPDGSD ESKATCSSEE
     CPAEKLSCGP TSHKCVPASW RCDGEKDCEG GADEAGCPTS APGPCRENEF QCGDGTCVLA
     IKRCNQERDC PDGSDEAGCL QESTCEGPRR FQCKSGECVD GGKVCDDQRD CRDWSDEPQK
     VCGLNECLHN NGGCSHICTD LKIGFECTCP AGFQLLDQKT CGDIDECQDP DACSQICVNY
     KGYFKCECHP GYEMDTLTKN CKAVAGKSPS LIFTNRHEVR RIDLVKRDYS RLIPMLKNVV
     ALDVEVATNR IYWCDLSYRK IYSAHMDKAS IPDEQVVLID EQLHSPEGLA VDWVHKHIYW
     TDSGNKTISV ATTDGRRRCT LFSRELSEPR AIAVDPLRGF MYWSDWGFQA KIEKAGLNGA
     DRQTLVSDNI EWPNGITLDL LSQRLYWVDS KLHQLSSIDF NGGNRKMLIF STDFLSHPFG
     VAVFEDKVFW TDLENEAIFS ANRLNGLEIA ILAENLNNPH DIVIFHELKQ PKAADACDLS
     AQPNGGCEYL CLPAPQISSH SPKYTCACPD TMWLGPDMKR CYRAPQSTST TTLASAMTRT
     VPATTRAPGT TIHDPTYQNH STETPSQTAA APHSVNVPRA PSTSPSTPSP ATSNHSQHYG
     NEGSQMGSTV TAAVIGVIVP IVVIALLCMS GYLIWRNWKR KNTKSMNFDN PVYRKTTEEE
     EEDELHIGRT AQIGHVYPAA ISNYDRPLWA EPCLGETRDL EDPAPALKEL FVLPGEPRSQ
     LHQLPKNPLS ELPVVKCKRV ALSLEDDGLP
//
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