ID F6Z4P0_ORNAN Unreviewed; 1021 AA.
AC F6Z4P0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0000313|Ensembl:ENSOANP00000015055.2};
GN Name=CRIM1 {ECO:0000313|Ensembl:ENSOANP00000015055.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000015055.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000015055.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000015055.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000015055.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000015055.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6Z4P0; -.
DR STRING; 9258.ENSOANP00000015055; -.
DR Ensembl; ENSOANT00000015058.3; ENSOANP00000015055.2; ENSOANG00000009476.3.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160910; -.
DR HOGENOM; CLU_008434_0_0_1; -.
DR InParanoid; F6Z4P0; -.
DR OMA; FNNVEYH; -.
DR OrthoDB; 2946817at2759; -.
DR TreeFam; TF106451; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000009476; Expressed in adult mammalian kidney and 8 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 6.20.200.20; -; 6.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00093; VWC; 6.
DR SMART; SM00121; IB; 1.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 3.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1021
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027678224"
FT TRANSMEM 926..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..97
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 319..376
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 386..442
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 454..483
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 490..517
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 524..549
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 552..577
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 592..649
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 663..721
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 737..795
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 803..860
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 1021 AA; 112450 MW; DACC13752763C5E5 CRC64;
MHPWLVLVSV VLLGWGGRAL VCLPCDESKC EEPKSCPGST VQGVCGCCYT CARQRNETCG
GVYGLHGACD RGLRCVIRPP LNGDSITEYE VGVCEDENWD DDQLLGFEPC NENLITGCNI
INGKCECDTI RTCNNPFEFP RQDACLSALK RIEEEKPDCS KARCEVQFSP RCPEDSILIE
GYAPPGECCP LPSRCVCNPA GCLRKVCQPG YLNILVSKAS GKPGECCDLY ECKPVFSVDC
STVECPSIQQ VVCPLDSYET QVRLTADGCC ALPTRCECLS GLCGFPMCEV GSIPRVVSRG
DGTPGKCCDV FECVNETKPA CVFNSVEYYD GDVFRMDACR FCRCQGGVSI CFSAQCGELN
CDRYYVPEGE CCPVCKDPVY PFNNTAGCYA NGQIRAHGDR WREDDCTFCQ CSNGEPHCVA
TACGQSCLNP VKVPGECCPV CEEPTYITID PPACEAISNC TLTEKDCIYG FRLDHNGCRI
CQCRNREELC TGLILGCTLD CPFGFQTDAH NCEICQCRPR PKKCRPIICD KHCPFGYLKS
KHGCDLCRCQ KCPELPCSKV CPAGLQLDSH GCPMCKCRET PTSSAGPPVQ TGTCLSMDGR
HHKNEESWHD GCRECYCHNG REMCALITCP VPGCSNPTIH SGQCCPSCSD DLIVQKPELS
STSICHAPGG EYFVEGETWN IDSCTQCTCH SGRVLCETEV CPPLLCQNPS RTQDSCCPQC
SDEPLQPSSS NNESMPSYCK NDEGDIFLAA ESWKPDVCTS CICMDGMISC YSESCPPASC
ERPVLRKGQC CPYCIEDTMP KKVVCHFSGK TYADEERWDI DSCTHCYCLQ GQTLCSTVSC
PPLPCTEPIN VEGSCCPMCP EMYIPEPTNI PIEKTNQRGE IELQVPIWPS PSENEIGHLP
RDMAHLQVGY RDSEPHLNED TSFDSVAWVT VPVVIALILI IALLLINRKK QWIPVPCYRT
PTKPSCLNNQ LVYVDCKKGT MVQVDSSQRM LRIADPDARF SGFYSMQKQN NLQADNFYQT
V
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