ID F6Z5P0_ORNAN Unreviewed; 420 AA.
AC F6Z5P0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003069.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000003069.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003069.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000003069.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003069.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6Z5P0; -.
DR STRING; 9258.ENSOANP00000003069; -.
DR Ensembl; ENSOANT00000003070.3; ENSOANP00000003069.3; ENSOANG00000001933.4.
DR eggNOG; ENOG502QSPZ; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_767189_0_0_1; -.
DR InParanoid; F6Z5P0; -.
DR OMA; AEWEQIG; -.
DR TreeFam; TF336431; -.
DR Proteomes; UP000002279; Chromosome 2.
DR Bgee; ENSOANG00000001933; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR PANTHER; PTHR11861:SF10; TRANSMEMBRANE PROTEIN 130; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..194
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 420 AA; 46150 MW; 101A27B1CBB91BE3 CRC64;
MNSAFWFPVQ YDLRLSTDGP TTTGADGLVL ATLIAGNGSH AVFPDDLKQY RFHWVYSPLL
LTGKSEGEFN SAISVTGQSP GDFPIAVWVT PADCWLCQPL AKGFTLLHVT EFIVGNLIMV
QRDGISSQAK QGSRLARDTT TQASFVLHDP SNYFKSASFL YNWDFGDGTQ LVTEDSFVYY
NYSTAGTCTV HLKVVAEWKQ LKKSPDEKGL VQKTGEFTAS LELLDAIQSI QVLGSSETHV
MQTLNFSLQI TGSPPLALCW LVKSDCIPLE GDECHLVEIN GTSCNVSHTF NVPGRYCLSV
RAQNAVNRLH QYHPITVGAT GIHPAVFALP CVALISVMLG LIVYATFRST SQPKDLVEVA
DFDFSPMSDK STVDSEAEGR CAWVCCRCCP LQAPHGYREI IRETHGLLHP LHKPAKTYMV
//
