ID F6ZE98_CIOIN Unreviewed; 300 AA.
AC F6ZE98;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DRBM domain-containing protein {ECO:0000259|PROSITE:PS50137};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000012805.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000012805.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01000847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6ZE98; -.
DR STRING; 7719.ENSCINP00000012805; -.
DR Ensembl; ENSCINT00000012805.3; ENSCINP00000012805.3; ENSCING00000011306.2.
DR GeneTree; ENSGT00940000172936; -.
DR HOGENOM; CLU_048292_0_1_1; -.
DR InParanoid; F6ZE98; -.
DR OMA; MSENGEC; -.
DR TreeFam; TF315953; -.
DR Proteomes; UP000008144; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016442; C:RISC complex; IBA:GO_Central.
DR GO; GO:0070578; C:RISC-loading complex; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0035197; F:siRNA binding; IBA:GO_Central.
DR GO; GO:0070920; P:regulation of regulatory ncRNA processing; IBA:GO_Central.
DR GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR CDD; cd19862; DSRM_PRKRA-like_rpt1; 1.
DR CDD; cd19863; DSRM_PRKRA-like_rpt2; 1.
DR CDD; cd19864; DSRM_PRKRA-like_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1.
DR PANTHER; PTHR46205:SF3; LOQUACIOUS, ISOFORM B; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR PROSITE; PS50137; DS_RBD; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 21..88
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 115..183
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 229..297
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 33020 MW; 2514B8C557EDD562 CRC64;
MAGCSESQTE DLQNESQTFK TPVSTLQEYC QKLSKTPQYD LTALEGRAHQ PQFVYRCMVG
DVTATGQGGS KKIAKHAAAE AVLKTLTNGL VEPESFPDVM ETSAVEYGRD VDDTNPVGSL
QELVVARGWR LPEYALAHET GPAHKKEFII CCTVESFKEY GSGSAKKHAK RLAAANMFTK
IMNLPPEAKE TVTNQSREAK NKIGLNEICN SVGEKQNFFH VRFANCDQNP CQVLEELANK
HSFDAVYKDI EQTTVNGDRQ CLLEVSTQPP CVLHGRGKSL NQSHSDAAVN ALEYLTIFGN
//
