ID F6ZJV8_CALJA Unreviewed; 597 AA.
AC F6ZJV8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5C {ECO:0000313|Ensembl:ENSCJAP00000013064.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000013064.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000013064.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000013064.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; F6ZJV8; -.
DR Ensembl; ENSCJAT00000013771.5; ENSCJAP00000013064.4; ENSCJAG00000006998.6.
DR GeneTree; ENSGT00950000182815; -.
DR Proteomes; UP000008225; Chromosome 3.
DR Bgee; ENSCJAG00000006998; Expressed in cerebellum and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Developmental protein {ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..597
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023900675"
FT TRANSMEM 396..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 175..256
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 549..597
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 597 AA; 66126 MW; 99087AC2C32C9DE2 CRC64;
MRKGLRATAA RCGLGLGYVL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE
GQSVQKITCT TLCPVDGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK
NCTDGLCMQS FIYPISTEQR TQNEYGFSSA PDSDDVALYV GIVIAVIVCL AISVVVALFV
YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD
KIPMTNSPIL DPLPNLKIKV YNTSGAVTPQ DELSEFTSKL SPQMTQSLLE NEALNLKNQS
LARQTDPSCT AFGSFNSLGG HLIVPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKETMR
//
