ID F6ZKH5_XENTR Unreviewed; 580 AA.
AC F6ZKH5; A0A6I8PUD7; Q6DJ34;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=NADPH oxidase activator 1 {ECO:0000313|EMBL:AAH75351.1, ECO:0000313|Ensembl:ENSXETP00000008571};
GN Name=noxa1 {ECO:0000313|EMBL:AAH75351.1,
GN ECO:0000313|Ensembl:ENSXETP00000008571,
GN ECO:0000313|RefSeq:NP_001005801.1,
GN ECO:0000313|Xenbase:XB-GENE-6257646};
GN Synonyms=ny-co-31 {ECO:0000313|RefSeq:NP_001005801.1}, p51-nox
GN {ECO:0000313|RefSeq:NP_001005801.1}, p51nox
GN {ECO:0000313|RefSeq:NP_001005801.1}, sdccag31
GN {ECO:0000313|RefSeq:NP_001005801.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000008571};
RN [1] {ECO:0000313|RefSeq:NP_001005801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH75351.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH75351.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000008571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000008571};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000008571}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001005801.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC075351; AAH75351.1; -; mRNA.
DR RefSeq; NP_001005801.1; NM_001005801.1.
DR STRING; 8364.ENSXETP00000011052; -.
DR PaxDb; 8364-ENSXETP00000008571; -.
DR DNASU; 448279; -.
DR Ensembl; ENSXETT00000008571; ENSXETP00000008571; ENSXETG00000003959.
DR Ensembl; ENSXETT00000065840; ENSXETP00000062537; ENSXETG00000003959.
DR Ensembl; ENSXETT00000113044; ENSXETP00000119260; ENSXETG00000003959.
DR Ensembl; ENSXETT00000115494; ENSXETP00000108869; ENSXETG00000003959.
DR GeneID; 448279; -.
DR KEGG; xtr:448279; -.
DR AGR; Xenbase:XB-GENE-6257646; -.
DR CTD; 10811; -.
DR Xenbase; XB-GENE-6257646; noxa1.
DR eggNOG; KOG4225; Eukaryota.
DR OrthoDB; 11738at2759; -.
DR TreeFam; TF329087; -.
DR Reactome; R-XTR-5668599; RHO GTPases Activate NADPH Oxidases.
DR Reactome; R-XTR-9013149; RAC1 GTPase cycle.
DR Reactome; R-XTR-9013423; RAC3 GTPase cycle.
DR Proteomes; UP000008143; Chromosome 8.
DR Bgee; ENSXETG00000003959; Expressed in liver and 12 other cell types or tissues.
DR CDD; cd12047; SH3_Noxa1_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15175:SF4; NADPH OXIDASE ACTIVATOR 1; 1.
DR PANTHER; PTHR15175; NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF13432; TPR_16; 1.
DR PRINTS; PR00499; P67PHOX.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 37..70
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 236..294
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 520..579
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 398..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 64460 MW; 37BA66372E8261C8 CRC64;
MHYKEVVRRW HEGVVAAEGK DYDAALRSFT AIEDPPSRIW FNVGGIYLLR GDLPRALEAY
DKSLAQDPCL AVGYYQRGYL QFKLGRYEKA LSDCHLALSN LRNNSFIDYK QLGLRHVLFS
WEAQYNMAAV LCSLGRWESA EEKLKETLQG DGRNAKLDWA LDQVQRRSLL QPMSVPEGEF
FRPRKQEVEQ LNSVDFLGKP TVISSVVPND QYSGFEPLRP QQPGFYEPCR DAMQCREAGY
HRVVVHYYPE NSNEVAVKAN SVLFVLNKDG DWATAIHDGQ KILIPTSFLE PTNPPKADIK
KMNNGIPLPP MKTPPTRPNV RPGMEPLTGV QAGAPVPPQP AGGAAEPYKI KALPVGMEPI
VEVAVPVQRS VPTHKETGNV PLGNDASLVE DAGRTIIKPK GESAPEPGPF PTRQTGPDNG
PMATPVPTDD DKLVLSVHAE FTVNMTVSKA ITYPELQGAL REELRKHGEQ MANHLSYRDP
ESRGLTPVTG SKDWQEVLKL SRANQVTLCC KETTLCAGRP VLYRMRAQYD YLAQGPADLS
FQQGDLISIL SEVNGEWLEG HCHRGIGIFP KCFAQRAEGI
//
