GenomeNet

Database: UniProt
Entry: F6ZLY8_HORSE
LinkDB: F6ZLY8_HORSE
Original site: F6ZLY8_HORSE 
ID   F6ZLY8_HORSE            Unreviewed;       658 AA.
AC   F6ZLY8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   24-JAN-2024, entry version 72.
DE   SubName: Full=Neuronal guanine nucleotide exchange factor {ECO:0000313|Ensembl:ENSECAP00000009365.3};
GN   Name=NGEF {ECO:0000313|Ensembl:ENSECAP00000009365.3,
GN   ECO:0000313|VGNC:VGNC:20726};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009365.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000009365.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009365.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000009365.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009365.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F6ZLY8; -.
DR   STRING; 9796.ENSECAP00000009365; -.
DR   PaxDb; 9796-ENSECAP00000009365; -.
DR   Ensembl; ENSECAT00000011924.3; ENSECAP00000009365.3; ENSECAG00000011222.4.
DR   VGNC; VGNC:20726; NGEF.
DR   GeneTree; ENSGT01030000234571; -.
DR   InParanoid; F6ZLY8; -.
DR   TreeFam; TF316357; -.
DR   Proteomes; UP000002281; Chromosome 6.
DR   Bgee; ENSECAG00000011222; Expressed in articular cartilage of joint and 14 other cell types or tissues.
DR   ExpressionAtlas; F6ZLY8; baseline.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047270; PH_ephexin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   PANTHER; PTHR12845:SF8; EPHEXIN-1; 1.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          187..371
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          403..515
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          15..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..141
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..612
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..630
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        638..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  74513 MW;  786513720564CDCC CRC64;
     MELLAAAFSA ACAVDHDSST SESDARDSVV GHLPGSESSS TPGNGATPEE CPALADSPTT
     LTEALQMIRP IPADSWRNLI EQIGLLYQEY RDKSTLQEIE TRRQQDAQIH ANVHGSPAGQ
     ETPEEEEEEE EEEEEEEEEE PASPPERRAL PQICLLSNPH SRFNLWQDLP EIQSSGVLEI
     LQPEEIRLQE AMFELVTSEA SYYKSLSLLV SHFMENERLK KMLHPSEAHI LFSNVLDVMA
     VSERFLLELE RRMEENIVIS DVCDIVHHYA ANHFSVYITY VSNQTYQERT YKQLLQEKAA
     FRELIAQLEL DPKCRGLPLS SFLILPFQRI TRLKLLVQNI LKRVEERSER ECTALDAHKE
     LELVVKSCNE GVRKMSRTEQ MISIQKKMEF KIKSVPIISH SRWLLKQGEL QQMSGPKTSR
     TLRTKKLFQD IYLFLFNDLL VICRQIPGDK YQVFDSAPRG LLRVEELEDQ GQTLANVFIL
     RLLENADDRE ATYMLKASSQ SEMKRWMTSL APNRRTKFVS FTSRLLDCPQ VQCVHPYVAQ
     QPDELTLELA DILNILEKTE DGEARGWRIS RSGPPGCPVP LLSSPGAPRS ALPLSTRPER
     PAPRPLHLVP PWPGPTKHKG RRDGREHPDP DPGLATSFQG GSLASVCTTR REAGSPAT
//
DBGET integrated database retrieval system