ID F6ZLY8_HORSE Unreviewed; 658 AA.
AC F6ZLY8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Neuronal guanine nucleotide exchange factor {ECO:0000313|Ensembl:ENSECAP00000009365.3};
GN Name=NGEF {ECO:0000313|Ensembl:ENSECAP00000009365.3,
GN ECO:0000313|VGNC:VGNC:20726};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009365.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009365.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009365.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009365.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009365.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; F6ZLY8; -.
DR STRING; 9796.ENSECAP00000009365; -.
DR PaxDb; 9796-ENSECAP00000009365; -.
DR Ensembl; ENSECAT00000011924.3; ENSECAP00000009365.3; ENSECAG00000011222.4.
DR VGNC; VGNC:20726; NGEF.
DR GeneTree; ENSGT01030000234571; -.
DR InParanoid; F6ZLY8; -.
DR TreeFam; TF316357; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000011222; Expressed in articular cartilage of joint and 14 other cell types or tissues.
DR ExpressionAtlas; F6ZLY8; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR12845:SF8; EPHEXIN-1; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 187..371
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 403..515
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 15..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..141
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..612
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 74513 MW; 786513720564CDCC CRC64;
MELLAAAFSA ACAVDHDSST SESDARDSVV GHLPGSESSS TPGNGATPEE CPALADSPTT
LTEALQMIRP IPADSWRNLI EQIGLLYQEY RDKSTLQEIE TRRQQDAQIH ANVHGSPAGQ
ETPEEEEEEE EEEEEEEEEE PASPPERRAL PQICLLSNPH SRFNLWQDLP EIQSSGVLEI
LQPEEIRLQE AMFELVTSEA SYYKSLSLLV SHFMENERLK KMLHPSEAHI LFSNVLDVMA
VSERFLLELE RRMEENIVIS DVCDIVHHYA ANHFSVYITY VSNQTYQERT YKQLLQEKAA
FRELIAQLEL DPKCRGLPLS SFLILPFQRI TRLKLLVQNI LKRVEERSER ECTALDAHKE
LELVVKSCNE GVRKMSRTEQ MISIQKKMEF KIKSVPIISH SRWLLKQGEL QQMSGPKTSR
TLRTKKLFQD IYLFLFNDLL VICRQIPGDK YQVFDSAPRG LLRVEELEDQ GQTLANVFIL
RLLENADDRE ATYMLKASSQ SEMKRWMTSL APNRRTKFVS FTSRLLDCPQ VQCVHPYVAQ
QPDELTLELA DILNILEKTE DGEARGWRIS RSGPPGCPVP LLSSPGAPRS ALPLSTRPER
PAPRPLHLVP PWPGPTKHKG RRDGREHPDP DPGLATSFQG GSLASVCTTR REAGSPAT
//