ID F6ZMY1_ORNAN Unreviewed; 559 AA.
AC F6ZMY1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Epoxide hydrolase 2 {ECO:0000313|Ensembl:ENSOANP00000017254.2};
GN Name=EPHX2 {ECO:0000313|Ensembl:ENSOANP00000017254.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017254.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017254.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017254.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000017254.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017254.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase
CC family. {ECO:0000256|ARBA:ARBA00038334}.
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DR AlphaFoldDB; F6ZMY1; -.
DR STRING; 9258.ENSOANP00000017254; -.
DR Ensembl; ENSOANT00000017257.2; ENSOANP00000017254.2; ENSOANG00000010887.3.
DR eggNOG; KOG3085; Eukaryota.
DR eggNOG; KOG4178; Eukaryota.
DR GeneTree; ENSGT00940000158614; -.
DR HOGENOM; CLU_036085_1_1_1; -.
DR InParanoid; F6ZMY1; -.
DR OMA; YAMEVLC; -.
DR TreeFam; TF315395; -.
DR Proteomes; UP000002279; Chromosome X2.
DR Bgee; ENSOANG00000010887; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0004301; F:epoxide hydrolase activity; IEA:Ensembl.
DR GO; GO:0042577; F:lipid phosphatase activity; IBA:GO_Central.
DR GO; GO:0052642; F:lysophosphatidic acid phosphatase activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0015643; F:toxic substance binding; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR GO; GO:0097176; P:epoxide metabolic process; IEA:Ensembl.
DR GO; GO:0046839; P:phospholipid dephosphorylation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
DR GO; GO:0046272; P:stilbene catabolic process; IEA:Ensembl.
DR CDD; cd02603; HAD_sEH-N_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR023198; PGP-like_dom2.
DR NCBIfam; TIGR01509; HAD-SF-IA-v3; 1.
DR PANTHER; PTHR43329:SF4; BIFUNCTIONAL EPOXIDE HYDROLASE 2; 1.
DR PANTHER; PTHR43329; EPOXIDE HYDROLASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 278..551
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 559 AA; 61688 MW; 50514688AB0623A4 CRC64;
MGKAAAAPTH PLRPLPPAAM ALRAALFELG GVLVGPSPRE VFSRTEEALS LPSGFFRKVT
TQGGQEGPFA RLLRGEFTVG QAVPLLDEAC RDISAAAGLQ LPTPFSIRRV FDEMGSGAEI
NIPMLQAAIA LRNRGWKTGI LSNTWVDDSP QRGQWAEISC ALAKHFDLRV ESCHVGVAKP
DPGIYLLALE ALGVRPHEAV CLDDTEANLR AALELGLVTV QARDTAAALE KLEQVTGMQP
LGPKEILLTA CRPDSVAHGQ VSVKPGVQLH FVEAGTGPAV CLCHGFPESW FSWRYQIPAL
ADAGFRVIAL DMKGYGDSSA PQAIEEYSQE EMCKEAVTFL DKLGISQAVF IGHDWGGMFV
WNMALFYPER VRAVASLNTP FMPADPSVPA MERIRALPVC DYQLYFQEPG VAEAELEANL
SRTLKLLIRA SDEKNFFTSF EVRKRGGLLV GMPEFSPTSR ILKEEDLRFY VQQFEKSGFR
GPLNWYRNME RNWRWSCTAV GRKIMVPALM ITAGKDPILT PQTSRHMEDW VPQLKRGHIE
ECGHWTQMER PGVGLFQTD
//
