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Database: UniProt
Entry: F6ZNY5_MACMU
LinkDB: F6ZNY5_MACMU
Original site: F6ZNY5_MACMU 
ID   F6ZNY5_MACMU            Unreviewed;      2026 AA.
AC   F6ZNY5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   30-AUG-2017, entry version 31.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 6 {ECO:0000313|Ensembl:ENSMMUP00000017218};
GN   Name=TRPM6 {ECO:0000313|Ensembl:ENSMMUP00000017218};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000017218, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000017218, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017218,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000017218}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017218};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000017218}.
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DR   EMBL; JSUE03015344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03015345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000018388; ENSMMUP00000017218; ENSMMUG00000013102.
DR   eggNOG; ENOG410INBW; Eukaryota.
DR   eggNOG; ENOG410ZSH9; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   Proteomes; UP000006718; Chromosome 15.
DR   Bgee; ENSMMUG00000013102; -.
DR   ExpressionAtlas; F6ZNY5; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029597; TRPM6.
DR   InterPro; IPR032415; TRPM_tetra.
DR   PANTHER; PTHR13800:SF21; PTHR13800:SF21; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    862       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    979    999       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1075       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1096   1116       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1754   1984       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
SQ   SEQUENCE   2026 AA;  231231 MW;  97559FE76CA52A10 CRC64;
     MFTFGLFVPI LSSQKSWIKG VFDKRECSTV IPSSKNPHRC TPACQFCQNL IRCYCGRLIG
     DHAGIDYSWT ISAAKGKESE QWSVEKHTMK SPTDTFGTIN FQDGEHTSHA KYIRTSYDTK
     LDHLLHLMLK EWKMELPKLV ISVHGGIQNF TMPSKFKEIF NQGLVKAAET TGAWIITEGI
     NTGVSKHVGD ALKSHSSHSL RKIWTVGIPP WGIIENQRDL IGKDVVCLYQ TLGNPLSKLT
     TLNSMHSHFI LSDDGTVGKY GNEMKLRRNL EKYLSLQKIH CRSRQGVPVV GLVVEGGPNV
     ILSVWETVKD KDPVVVCEGT GRAADLLAFT HKHLADEGML RPQVKEEIIC MIQNTFNFSL
     KQSKHLFQIL MECMVHRDCI TIFDADSEEQ QDLDLAILTA LLKGTNLSAS EQLNLAMAWD
     RVDIAKKHIL IYEQHWKPDA LEQAMLDALV MDRVDFVKLL IEYGVNLHCF LTIPRLEELY
     NTKQGPTNTL LHHLVQDVKQ HTLLSGYRIT LIDIGLVVEY LIGRAYRSSY TRKHFRALYN
     NLYRNQKHRR RSSGNRNESA ESTPHSQFIR TAQPYKFKEK SVVLHKSRKK SKEQNVSDDP
     ESTGFIYPYS DLLVWAVLMK RQKMAMFFWQ HGEEATVKAV IACILYRAMA HEAKESHMVD
     DASEELKNYS KQFGQLALDL LEKAFKQNER MAMTLLTYEL RNWSNSTCLK LAVSGGLRPF
     VSHTCTQMLL TDMWMGRLKM RKNSWLKIII SIILPPTILT LEFKSKAEMS HVPQSQDFQF
     MWYYSDQNAS SSKESASVKE YDLERGHDEK LDENQHFGLE SGPQHLPWTR KVYEFYSAPI
     VKFWFYTMAY LAFLMLFTYT VLVEMQPQPS AQEWLVSIYI FTSAIEAVRG ICTSEPGKFT
     QKVKVWISEY WNLTETVAIG LFSVGFALRW GDPPFHTAGR LIYCIDIIFW FSRLLDFFAV
     NQHAGPYVTM IAKMTANMFY IVIIMAIVLL SFGVARKAIL SPKEPPSWSL ARDIVFEPYW
     MIYGEVYAGD IDVCSSQPSC PPGSFLTPFL QAVYLFVQYI IMVNLLIAFF NNVYLDMESI
     SNNLWKYNRY RYIMTYLEKP WLPPPLILLS HVGLLLRRLC CHRAPHDQEE GDVGLKLYLS
     KEDLKKLHDF EEQCVEKYFH EKMEVVNCSC EERIRVTSER VTEMYFQLKE MNEKVSFIKD
     SLLSLDSQVG HLQDLSALTV DTLKVLSAVD TLQEDEALLA KRKHSTCKKL PHSWSNVICA
     EVLGSMEIAG EKKYQYYSMP SSLLRSLAGG RHPPRVQRGA LLEITDSKRD AANVRNDQEK
     QKTESSIVAS GGSPNKQAHS KYGQFLLVPS NLKRVPFSAE TVLPLSRPSV EADTDVLANE
     QDIHPEVLVH LTGQTPGVSD QASVDEPKEQ HEPIAHLMDG QDKSEQVLPT LSCTPEPMTV
     TSPLSQAKSM QTEGGYVNWA FSEGDETGVF SIKKKWQTSL PSTCDSDSTR SEQHQKQTQG
     SSLSDNSTRS AQSSECSEVG PWLQPNTSFW INPLRRDRPF ARSHSFRFHK EEKLMKICKI
     KNLSSSSEIG QGAWVKAKML TKDRRLSKKK KNTQGLQVPI ITVNACSQSD QLNPEPGENS
     ISEEEYSKNW FTVSKCGQTS VKPYIHQKTK TKDIGQCAVQ VSDYLKQSQE DLSKNALWNS
     RSTNLNRNSL LKSSNGVDKI SASLKSPQEP HHHYSAIERN NLMRLSQTIP FTPIQLFAGE
     EITVYRLEES SPLNLDKSVS SWSQRGRAAM IQVLSREEMD GGLRKAMRVV STWSEDDILK
     PGQVFIVKSF LPEVVRTWHK IFQESTVLHL CLREIQQQRA AQKLIYTFNQ VKPQTIPYTP
     RFLEVFLIYC HSANQWLTIE KYMTGEFRKY NNNNGDEITP TSTLEELMLA FSHWTYEYTR
     GELLVLDLQG VGENLTDPSV IKPEVKQSRG MVFGPANLGE DAIRNFIAKH NCNSCCRKLK
     LPDLKRNDYS PERINSTFGL EIKIESAEEP PARERGRNSP EDDMQL
//
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