ID F6ZU08_HORSE Unreviewed; 1828 AA.
AC F6ZU08;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=E3 ubiquitin-protein ligase listerin {ECO:0000256|ARBA:ARBA00017157, ECO:0000256|RuleBase:RU367090};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483, ECO:0000256|RuleBase:RU367090};
DE AltName: Full=RING-type E3 ubiquitin transferase listerin {ECO:0000256|ARBA:ARBA00032366, ECO:0000256|RuleBase:RU367090};
GN Name=LTN1 {ECO:0000313|VGNC:VGNC:19836};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009027.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009027.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009027.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009027.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009027.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome
CC quality control complex (RQC), a ribosome-associated complex that
CC mediates ubiquitination and extraction of incompletely synthesized
CC nascent chains for proteasomal degradation.
CC {ECO:0000256|RuleBase:RU367090}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU367090};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|RuleBase:RU367090}.
CC -!- SUBUNIT: Component of the ribosome quality control complex (RQC).
CC {ECO:0000256|RuleBase:RU367090}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the LTN1 family. {ECO:0000256|ARBA:ARBA00007997,
CC ECO:0000256|RuleBase:RU367090}.
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DR STRING; 9796.ENSECAP00000009027; -.
DR PaxDb; 9796-ENSECAP00000009027; -.
DR Ensembl; ENSECAT00000011535.4; ENSECAP00000009027.3; ENSECAG00000010824.4.
DR CTD; 26046; -.
DR VGNC; VGNC:19836; LTN1.
DR GeneTree; ENSGT00390000016055; -.
DR HOGENOM; CLU_002412_0_0_1; -.
DR InParanoid; F6ZU08; -.
DR OMA; IYGSHWE; -.
DR OrthoDB; 179130at2759; -.
DR TreeFam; TF314286; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002281; Chromosome 26.
DR Bgee; ENSECAG00000010824; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6ZU08; baseline.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:1990112; C:RQC complex; IBA:GO_Central.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd16491; RING-CH-C4HC3_LTN1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039795; LTN1/Rkr1.
DR InterPro; IPR039804; RING-CH-C4HC3_LTN1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12389:SF0; E3 UBIQUITIN-PROTEIN LIGASE LISTERIN; 1.
DR PANTHER; PTHR12389; ZINC FINGER PROTEIN 294; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367090};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367090};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU367090};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367090};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1777..1824
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1828 AA; 206768 MW; 49D4673B150221D9 CRC64;
MVRDAAGGGS GSGAAGGQGV WRKGWAGRSR PSGPSSGARG RKLWPGRVNR DQRAESAAET
PTMGGKNKQR TKGNLRPSNS GRAAELLAKE QGTVPGFIGF GTSQSDLGYV PAIQGAEEID
SLVDSDFRMV LRKLSKKDVT TKLKAMQEFG IMCTERDTEI VKGVLPYWPR IFCKISLDHD
RRVREATQQA FEKLILKVKK HLAPYLKSLM GYWLMAQCDT YTPAASAAKD AFEAAFPPSK
QPEAIAFCKD EITIVLQDHL IKETPDTLSD PQTVPEEERE AKFYRVVTCS LLALKKLLCL
LPDNELDSLE EKFKSLLSQN KFWKYGKHSI PQIRSAYFEL VSALCLRIPQ LMKDEASKVS
PSVLLSIDDS DPIVCPALWE AVLYTLTTIE DCWLHVNAKK SVFPKLSAVV REGGRGLATV
IYPYLLPFIS KLPQSITDPK LDFFKNFLTS LIVGLSTERI KTSFSECSAV ISAFFECLRF
IMQQNLGEKE IEEMLVNDQL IPFIDAVLKD PKLQDGQLFN HLAETLNSWE AKADMEKDDK
TVHNLEKVLL NFWERLSEIC VEKINEPEAD LKSVLGVSNL LQVLQKPKSS LKSNKKKVSK
VRFADEMPES NKENEKCVSS EGENSEGSEL VAELSLTHNC SDVISPLRKK PLEDLVCKLA
EMSINYVNEQ KSEQHLRFLS TLLNSFSSTQ VFKMLLGDEK QSVVKAKPPE ITKLAQKNPA
VQFLYQKLIG WLNEDPKKDA GFLVDILYSA LRCCDNNMER KDVLDDLTKV DLNWNSVLQV
IEKACSSSDK HALVTPWLKG DILGEELVTL AEHLCNKHLE SKGSSESYFS ERWTLLSLVL
SQHVKDDYLI GEVYVERIIV KLHETLSKTE TLTEAENNDS SVSFICDVAY NYFSSAKGCL
LMPSSEDLLL TLFQLCAQSK EKTHLPDFLI CKLKNTWLSG VNLLVHQTGS IYKQSTFLRL
SALWLKNQVQ SSSLDIKSLQ VLLSTVDDLL NALVESEDTY LLGVYIGSVM PNNSEWEKMR
QSLPIQWLHR PLLEGRLSLN YECFKTDFKE QDTKKLPSHL CTSALLSKMI LVALKKEIVL
ENNELEKIIA ELLYSLQWCE ELDNPPIFLT GFCEMLQKMN ITYDNLCGLG NTSGLLQLLF
NRSRENGTLW SLIIAKLILS RSVSSDEVKR HYRRKECFFP LTEGNMHTIQ SLCPFLSKED
KKEFIAQCIP ALLAWTKEDL CSTNGGFGHL AIFNSCLQTR SIDDEELLHG ILKILISWKK
DHEDIFLFSC NLSEVSPEIL GVNIEIIRFL SLFLKYCSSP LAESEWDFIM CSMLAWLETT
SENQALYSVP LVQLFACVSC DLACKLSAFF DSTTLDTTGN LPVNLISEWK EFFSQGIHSL
LLPLLVNVTG ESKDTSETSF HNAMLKPMCE TLTYIPKDQL LSHKLPARLV AGQKTNLPEY
LQTLLNTLVP LLLFRARPVQ IAVYHMLYKL MPELPQYDQD NLKSYGDEEE EPALSPPAAL
MSLLSTQEDL LENVLGCIPV GQIVTIKPLS EDFCYVLGYL LTWKLILTFF KAASSQLRAL
YSMYLRKTKS LNKLLYHLFR LMPENPTYAE TAIELSNKDP KTFFTEELQL SIRETATLPY
HIPHLACSVY HMTLKDLPAM VRLWWNSSEK RVFNIVDRFT SKYVSNVLSF QEISSVQTST
QLFNGMTVKA RATTREVMAT YTIEDIVIEL IIQLPSNYPL GSITVESGKR VGVAVQQWRN
WMLQLSTYLT HQNGSIMEGL ALWKNNVDKR FEGVEDCMIC FSVIHGFNYS LPKKACRTCK
KKFHSACLYK WFTSSNKSTC PLCRETFF
//
