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Database: UniProt
Entry: F6ZY03_CALJA
LinkDB: F6ZY03_CALJA
Original site: F6ZY03_CALJA 
ID   F6ZY03_CALJA            Unreviewed;      1967 AA.
AC   F6ZY03;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1C {ECO:0000313|Ensembl:ENSCJAP00000001544};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000001544, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000001544, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000001544}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000001544}.
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DR   EMBL; ACFV01120723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01120732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000001640; ENSCJAP00000001544; ENSCJAG00000000732.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000008225; Chromosome 9.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     38     56       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    109    131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    187    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    220    242       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    471    496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    549    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    707    729       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    749    770       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    782    808       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    828    857       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1010   1031       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1043   1061       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1073   1090       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1153   1171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1247   1270       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1404   1438       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      579    602       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1967 AA;  221124 MW;  78E7BD68DA0F8322 CRC64;
     ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD
     GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
     IIYAIIGLEL FMGKMHKTCY NQEGIAAEDD PSPCALETGH GRQCQNGTVC RPGWDGPKHG
     ITNFDNFAFA MLTVFQCITM EGWTDVLYWM QDAMGYELPW VYFVSLVIFG SFFVLNLVLG
     VLSGEFSKER EKAKARGDFQ KLREKQQLEE DLKGYLDWIT QAEDIDPENE DEGMDEEKPR
     NMSMPTSETE SVNTENVAGG DIEGENCGAR LAHRISKSKF SRYWRRWNRF CRRKCRAAVK
     SNVFYWLVIF LVFLNTLTIA SEHYNQPHWL TEVQDTANKA LLALFTAEML LKMYSLGLQA
     YFVSLFNRFD CFVVCGGILE TILVETKIMS PLGISVLRCV RLLRIFKITR YWNSLSNLVA
     SLLNSVRSIA LGMQLFGGKF NFDEMQTRRS TFDNFPQSLL TVFQILTGED WNSVMYDGIM
     AYGGPSFPGM LVCIYFIILF ICGNYILLNV FLAIAVDNLA DAESLTSAQK EEEEEKERKK
     LASQIPMEKR RERKTPSGKK ASGDGQINMD DLQPNENEDK SPYPNPETTV HREKGEDDEE
     EPEMPVGPRP RPLSELHLKE KAVPMPEASA FFIFSSNNRF RLQCHRIVND TIFTNLILFF
     ILLSSISLAA EDPVQHTSFR NHILGNADYV FTSIFTLEII LKMTAYGAFL HKGSFCRNYF
     NILDLLVVSV SLISFGIQSS AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI
     GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG EVDHPIIQPR
     SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR VVGFVIVTFQ
     EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
     LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI
     VIGSIIDVIL SETNPHEQTH IPQPLALPGN AEENSRISIT FFRLFRVMRL VKLLSRGEGI
     RTLLWTFIKS FQALPYVALL IVMLFFIYAV IGMQVFGKIA LNDTTEINRN NNFQTFPQAV
     LLLFRCATGE AWQDIMLACM PGKKCAPESE PSNSTEGETP CGSSFAVFYF ISFYMLCAFL
     IINLFVAVIM DNFDYLTRDW SILGPHHLDE FKRIWAEYDP EAKGRIKHLD VVTLLRRIQP
     PLGFGKLCPH RVACKRLVSM NMPLNSDGTV MFNATLFALV RTALRIKTEG NLEQANEELR
     AIIKKIWKRT SMKLLDQVVP PAGDDEVTVG KFYATFLIQE YFRKFKKRKE QGLVGKPSQR
     NALSLQAGLR TLHDIGPEIR RAISGDLTAE EELDKAMKEA VSAASEDDIF RRAGGLFGNH
     VSYYQSDGRS AFPQTFTTQR PLHINKAGSS QGDTESPSHE KLVDSTFTPS SYSSTGSNAN
     INNANNTALG RLPRPSLCPL QTVQTTGHQA SAWCHSRESQ TAVVGQEETS QDETYEVKMN
     DDTEACSEPS LLSTEISFSG FFHDRHLSEG SELFSELESF EDRSGRCQGQ ARTSWGGNSP
     NRHVSTKLSY QDDENRQLTL PEEDKRDIRQ SPKRGFLRTA SLGRRASFHL ECLKRQKDRA
     GDISQKTVLP LHLVHHQALA VAGLSPLLQR SHSPASFPRP FATPPATPGS RGWPPQPIPT
     LRLEGAESIE KLNSSFPSIH CGSWAETTPC GGGSSAARRA RPVSLTVPSQ AGAPGRQFHG
     SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ ELADACDMTI EEMESAADNI LSGGAPQSPN
     GALLPFVNCR DAGQDLAGGE EDAGCVLARG RLSEEELQDS RVYVSSL
//
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