ID F7A1Q9_CIOIN Unreviewed; 380 AA.
AC F7A1Q9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Delta(24)-sterol reductase-like {ECO:0000313|Ensembl:ENSCINP00000017078.3};
GN Name=LOC100181233 {ECO:0000313|Ensembl:ENSCINP00000017078.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000017078.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000017078.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01002575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F7A1Q9; -.
DR Ensembl; ENSCINT00000017078.3; ENSCINP00000017078.3; ENSCING00000008369.3.
DR GeneTree; ENSGT00390000008338; -.
DR HOGENOM; CLU_025883_4_1_1; -.
DR Proteomes; UP000008144; Chromosome 8.
DR GO; GO:0050614; F:delta24-sterol reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR040165; Diminuto-like.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR10801; 24-DEHYDROCHOLESTEROL REDUCTASE; 1.
DR PANTHER; PTHR10801:SF0; DELTA(24)-STEROL REDUCTASE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..380
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003348167"
FT DOMAIN 1..96
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 380 AA; 44073 MW; D735B2A3F6742CEF CRC64;
MGQVTTLLLP LGWTLPIVPE LDDLTVGGLI MGTGVETSSH KYGLIQHVCE SYELVLPDGT
LTKCSRTENP DLFYAVPWSY GTLGFLVAAE IRIIPSKPYV RIKYHPAQSA DEMTQLFIKE
SMKTRENDFV EALAFSDESG VVMTANFCDV FESGKLNRIG HWYKPWFFKH VEDKLKNDQS
SVEYIPLRDY YHRHTRSIFW ELQDIIPFGN NPIFRLLVGW LMPPKISLLK LTQGKTVKRL
YEEHHVVQDM MLPIKHLSKC LKVFHDEIKL YPLWLCPFYL PKEPGMLAPP GDEGEMYVDV
GAYGEPRTLH FNNVKTIRQL EKATKDFNGF QMLYADSYMT REEFREMFDH SLYDKVRKSL
PLCDEAMPAI YDKVHKEIKE
//
