ID F7A1Y1_HORSE Unreviewed; 928 AA.
AC F7A1Y1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Inhibin beta B chain {ECO:0000256|ARBA:ARBA00014337};
DE AltName: Full=Activin beta-B chain {ECO:0000256|ARBA:ARBA00032422};
GN Name=INHBB {ECO:0000313|VGNC:VGNC:51463};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011917.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000011917.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011917.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000011917.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011917.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC {ECO:0000256|ARBA:ARBA00002588}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; F7A1Y1; -.
DR SMR; F7A1Y1; -.
DR STRING; 9796.ENSECAP00000011917; -.
DR PaxDb; 9796-ENSECAP00000011917; -.
DR Ensembl; ENSECAT00000014882.3; ENSECAP00000011917.2; ENSECAG00000014285.3.
DR VGNC; VGNC:51463; INHBB.
DR GeneTree; ENSGT00940000159862; -.
DR HOGENOM; CLU_020515_5_1_1; -.
DR InParanoid; F7A1Y1; -.
DR OMA; WWESFET; -.
DR TreeFam; TF351791; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000014285; Expressed in chorionic villus and 18 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19405; TGF_beta_INHBB; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000381; INHBB_C.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF29; INHIBIN BETA B CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00671; INHIBINBB.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 807..928
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..220
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..475
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..570
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 100798 MW; D00F83DDDCF99787 CRC64;
GCGEGSSARI RGREPVSAAQ RPAGRGSGAP TWWESFETAK VARHCGGGGE GTGPARPFSQ
RQRGKKPSEA GVGGGSRQHR PEQIPPPPPR PPRPGKPERG GTDSLLPHGQ DKTRSPLLFF
SPANVYLNAR AHTEIVRLFF PLGRKNEESK GRGQTEELLL GGLCTLCRGR ARGRSLHPPA
LSRSCGLCQR GSELGHRTRG RCETFRRSSR HRRRRGRRRD RGEKGPASAS PSSPGAPRPA
GPHRQAGRRR EGGSKEAGGA EAPAKRAAAG PPAGGCGGAP GAWRQLCRVT RREDCRARDR
GLRAASEPAR VPQRSQHCAR SPARGEDDPP VAGPSSAQGG EGEALRCQRG APPQRPPQRR
AKPRSASLRE LRSLRFRLGQ VASTGPFATF PARRPSRCCR CFHFARAGAA GPRRGEDGEK
AADAEAPRDA RAAVTRRPPP RPTHLCGLRG PRRPFPAARE PPRPSRPPPP ASPRRPSRRA
GGGPGGRGRG RGGAARREPG ARPCARLGSP HGGHPRRQRR TMDGLPGRAL GAACLLLLAA
GWLGPEAWGS PTPPPSPAAP PPPPPPGAPG GSQDTCTSCG GFRRPEELGR VDRDFLEAVK
RHILSRLQMR GRPNITHAVP KAAMVTALRK LHAGKVREDG RVEIPHLDGH ASPGADGQER
VSEIISFAET DGLASSRVRL YFFISNEGNQ NLFVVQASLW LYLKLLPYVL EKGSRRKVRV
KVYFQEQGHG DRWNVVEKKV DLKRSGWHTF PLTEAIQALF ERGERRLNLD VQCDGCQELA
VVPVFVDPGE ESHRPFVVVQ ARLGDSRHRI RKRGLECDGR TNLCCRQQFF IDFRLIGWND
WIIAPIGYYG NYCEGSCPAY LAGVPGSASS FHTAVVNQYR MRGLNPGTVN SCCIPTKLST
MSMLYFDDEY NIVKRDVPNM IVEECGCA
//
