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Database: UniProt
Entry: F7A252_ORNAN
LinkDB: F7A252_ORNAN
Original site: F7A252_ORNAN 
ID   F7A252_ORNAN            Unreviewed;       763 AA.
AC   F7A252;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 68.
DE   SubName: Full=Terminal nucleotidyltransferase 4A {ECO:0000313|Ensembl:ENSOANP00000018346.2};
GN   Name=TENT4A {ECO:0000313|Ensembl:ENSOANP00000018346.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000018346.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000018346.2, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018346.2,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA   Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA   Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA   Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA   Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA   Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA   Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA   Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA   Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA   Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA   Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA   Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA   Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA   Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA   Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA   de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000018346.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018346.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   AlphaFoldDB; F7A252; -.
DR   STRING; 9258.ENSOANP00000018346; -.
DR   Ensembl; ENSOANT00000018349.3; ENSOANP00000018346.2; ENSOANG00000011579.3.
DR   eggNOG; KOG1906; Eukaryota.
DR   GeneTree; ENSGT00940000157811; -.
DR   HOGENOM; CLU_013572_3_0_1; -.
DR   InParanoid; F7A252; -.
DR   OMA; KWGSRVH; -.
DR   OrthoDB; 21395at2759; -.
DR   TreeFam; TF313939; -.
DR   Proteomes; UP000002279; Chromosome X3.
DR   Bgee; ENSOANG00000011579; Expressed in fibroblast and 8 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0031499; C:TRAMP complex; IBA:GO_Central.
DR   GO; GO:0070568; F:guanylyltransferase activity; IEA:Ensembl.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0060212; P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:1905870; P:positive regulation of 3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0071076; P:RNA 3' uridylation; IEA:Ensembl.
DR   GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR   CDD; cd05402; NT_PAP_TUTase; 1.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002058; PAP_assoc.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   InterPro; IPR045862; Trf4-like.
DR   PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR   PANTHER; PTHR23092:SF24; TERMINAL NUCLEOTIDYLTRANSFERASE 4A; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   Pfam; PF03828; PAP_assoc; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN          237..345
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          400..459
FT                   /note="PAP-associated"
FT                   /evidence="ECO:0000259|Pfam:PF03828"
FT   REGION          28..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          573..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   763 AA;  84348 MW;  65C65BD4BBC0213A CRC64;
     MDPRVAWIQP EQKGPANALW MQIWETSQGM GRPGAGFPPY LCLNSPALDP PPSDGGRRLH
     KSPSLSSSSS CSSNNESGTE SPGFSSSSSS SSCGSLGPGG VFNFHDPKVH KGGGAGGPPQ
     GAPAGSPPQQ QQQQQQHHYH PGRRKRENKA STYGMNYLLS GSRGAALDGL PQLQRQQQLQ
     QLQQQQQQQE PPQPRPGTPW KTRTYSPGIQ GLHEEIIDFY NFMSPCPEEG IMRREVVKRI
     ETVIKDLWPT ADVQIFGSFS TGLYLPTSDI DLVVFGKWER PPLQLLEQAL RKHSVAEPKT
     IKVLDKATVP IIKLTDQETD VKVDISFNME TGVKAARFIK DYMKKYSLLP YLILVLKQFL
     LQRDLNEVFT GGISSYSLIL MAISFLQLHP RIDARRADEN LGMLLVEFFE LYGRNFNYLK
     TGIRIKNGGA YIAKEEIMKA MTNGYRPSML CIEDPLLPGN DVGRSSYGAI QVKQVFDYAY
     IVLSHAVSPL ARSFPNKDSE STLGRIIKVT QEVIDYRGWI KKKWGSKINL SPDLDNRIKM
     KEQITSCNGE QQQNRDDESP YSQRLTLSLT SSIQPLSSGS SASSVSSLSG SDIDSDTPPC
     TTPNVYQFTL QPPTQLMASL PPALQMPNGK PQSAPARTLI MTTNNQTRFT IPPPTIGVPP
     LPCRQVGIEG TPSLKAVHHL SSPAVPSASP NPLSSPHLYH KQHNGMKFSM KGTHNHNPGN
     GYNPVGSGSM RQPVGNRGHH QYNRTGWRRK KHMRDSLPIS LSR
//
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