ID F7A252_ORNAN Unreviewed; 763 AA.
AC F7A252;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Terminal nucleotidyltransferase 4A {ECO:0000313|Ensembl:ENSOANP00000018346.2};
GN Name=TENT4A {ECO:0000313|Ensembl:ENSOANP00000018346.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000018346.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000018346.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018346.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000018346.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018346.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; F7A252; -.
DR STRING; 9258.ENSOANP00000018346; -.
DR Ensembl; ENSOANT00000018349.3; ENSOANP00000018346.2; ENSOANG00000011579.3.
DR eggNOG; KOG1906; Eukaryota.
DR GeneTree; ENSGT00940000157811; -.
DR HOGENOM; CLU_013572_3_0_1; -.
DR InParanoid; F7A252; -.
DR OMA; KWGSRVH; -.
DR OrthoDB; 21395at2759; -.
DR TreeFam; TF313939; -.
DR Proteomes; UP000002279; Chromosome X3.
DR Bgee; ENSOANG00000011579; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0031499; C:TRAMP complex; IBA:GO_Central.
DR GO; GO:0070568; F:guanylyltransferase activity; IEA:Ensembl.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR GO; GO:0060212; P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR GO; GO:1905870; P:positive regulation of 3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0071076; P:RNA 3' uridylation; IEA:Ensembl.
DR GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR PANTHER; PTHR23092:SF24; TERMINAL NUCLEOTIDYLTRANSFERASE 4A; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 237..345
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 400..459
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 28..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 84348 MW; 65C65BD4BBC0213A CRC64;
MDPRVAWIQP EQKGPANALW MQIWETSQGM GRPGAGFPPY LCLNSPALDP PPSDGGRRLH
KSPSLSSSSS CSSNNESGTE SPGFSSSSSS SSCGSLGPGG VFNFHDPKVH KGGGAGGPPQ
GAPAGSPPQQ QQQQQQHHYH PGRRKRENKA STYGMNYLLS GSRGAALDGL PQLQRQQQLQ
QLQQQQQQQE PPQPRPGTPW KTRTYSPGIQ GLHEEIIDFY NFMSPCPEEG IMRREVVKRI
ETVIKDLWPT ADVQIFGSFS TGLYLPTSDI DLVVFGKWER PPLQLLEQAL RKHSVAEPKT
IKVLDKATVP IIKLTDQETD VKVDISFNME TGVKAARFIK DYMKKYSLLP YLILVLKQFL
LQRDLNEVFT GGISSYSLIL MAISFLQLHP RIDARRADEN LGMLLVEFFE LYGRNFNYLK
TGIRIKNGGA YIAKEEIMKA MTNGYRPSML CIEDPLLPGN DVGRSSYGAI QVKQVFDYAY
IVLSHAVSPL ARSFPNKDSE STLGRIIKVT QEVIDYRGWI KKKWGSKINL SPDLDNRIKM
KEQITSCNGE QQQNRDDESP YSQRLTLSLT SSIQPLSSGS SASSVSSLSG SDIDSDTPPC
TTPNVYQFTL QPPTQLMASL PPALQMPNGK PQSAPARTLI MTTNNQTRFT IPPPTIGVPP
LPCRQVGIEG TPSLKAVHHL SSPAVPSASP NPLSSPHLYH KQHNGMKFSM KGTHNHNPGN
GYNPVGSGSM RQPVGNRGHH QYNRTGWRRK KHMRDSLPIS LSR
//