ID F7A2S5_MACMU Unreviewed; 1304 AA.
AC F7A2S5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSMMUP00000012393.4};
GN Name=ARHGEF10 {ECO:0000313|Ensembl:ENSMMUP00000012393.4,
GN ECO:0000313|VGNC:VGNC:83981};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000012393.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000012393.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000012393.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMMUT00000013222.4; ENSMMUP00000012393.4; ENSMMUG00000009472.4.
DR VEuPathDB; HostDB:ENSMMUG00000009472; -.
DR VGNC; VGNC:83981; ARHGEF10.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_728717_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 8.
DR Bgee; ENSMMUG00000009472; Expressed in fibroblast and 21 other cell types or tissues.
DR ExpressionAtlas; F7A2S5; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 397..584
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 280..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 567..598
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1304 AA; 144621 MW; 9ECF8636CA5EC76B CRC64;
MDQREPPRPA PAENEMKYDT NNNEEEEGEQ FDFDSGDEIP EADRQAPSAP ETGGAGASEA
PAPTGGEDGA GAKATPVVEP AKLLLPVKVN PYSVIDIAPF QEDQPPAPAP STEEESVGLH
VPCGYSVPVP CGYAVPSNLP LLLPAYSSPV IIRATSLDEE AETPEVMEDR QPNSLSSEEP
PNSEDQVSRE DSALARWAAD PANTAWMENP EEAIYDDVPR ENSDSEPDEM IYDDVENGDE
GGNSSLEYGW SSSEFESYEE QSDSECKNGI PRSFLRSNHK KQLSHDLTRL KEHYEKKMRE
LMASTVGAVE IQQLRQKHEL KMQKLVKAAK DGTKDGLERT RAAVKRGRSF IRTKSLIAQD
HRSSLEEEQN LFIDVDCKHP EAILTPMPEG LSQQQVVRRY ILGSVVDSEK NYVDALKRIL
EQYEKPLSEM EPKFLSERKL KTVFYRVKEI LQCHSLFQIA LASRVSEWDS VEMIGDVFVA
SFSKSMVLDA YSEYVNNFST AVAVLKKTCA TKPAFLEFLK QEQEASPDRT TLYSLMMKPI
QRFPQFILLL QDMLKNTSKG HPDRLPLQMA LTELETLAEK LNERKRDADQ RCEVKQIAKA
INERYLNKLL SSGSRYLIRS DDMIETVYND RGEIVKTKER RVFMLNDVLM CATVSSRASH
DSRVMSSQRY LLKWSVPLGH VDAIEYGSSP GAGEHSRHLA VHPPESLAVV ANAKPNKVYM
GPGQLYQDLQ NLLHDLNVIG QITQLIGNLK GNYQNLNQSV AHDWTSGLQR LILKKEDEIR
AADCCRIQLQ LPGKQDKSGR PTFFTAVFNT FTPAIKESWV NSLQMAKLAL EEENHMGWFC
VEDDGNHIKK EKHPLLVGHM PVMVAKQQEF KIECAAYNPE PYLNNESQPD SFSTAHGFLW
IGSCTHQMGQ IAIVSFQNST PKVIECFNVE SRILCMLYIP VEEKRREPGA PLDPETPAVR
ASEVPTICVG TEEGSISIYK SSQGAKKVRL QHFFTPEKST VMSLACTSQS LYAGLVNGAV
ASYARAPDGS WDSEPQKVIE LGVLPVRSLL MMEDTLWAAS GGQVFIISVE THAVEGQLEA
HQEEGMVISH MAVAGVGIWI AFTSGSTLRL FHTETLKHLQ DINIATPVHN MLPGRGMVSY
HAHNGPVKFI ILATALHEKD KDKSGDGLAP GPEPQDEDQK DALPSEGTGS SLNQGDADTA
IWLGDSLGSM TQKSDVSSSS GSLSLSHGSS SLEHRSEDST ICDLLKDPVS LRSKARRAKK
AKASSALVVC GGQGHRRVHR KARQPHQEEL APSVMVWQIP LLNI
//
