GenomeNet

Database: UniProt
Entry: F7A8X1_MACMU
LinkDB: F7A8X1_MACMU
Original site: F7A8X1_MACMU 
ID   F7A8X1_MACMU            Unreviewed;      1976 AA.
AC   F7A8X1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   07-JUN-2017, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSMMUP00000024352};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000024352, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000024352, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000024352,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000024352}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000024352};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000024352}.
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DR   EMBL; JSUE03009022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9544.ENSMMUP00000024352; -.
DR   Ensembl; ENSMMUT00000026025; ENSMMUP00000024352; ENSMMUG00000018510.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000006718; Chromosome 12.
DR   Bgee; ENSMMUG00000018510; -.
DR   ExpressionAtlas; F7A8X1; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF235; PTHR10037:SF235; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    179    198       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    210    231       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    237    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    328    347       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    367    394       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    726    752       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    764    782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    802    823       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    844    872       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    934    957       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1221   1237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1313   1333       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1382   1403       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1423   1446       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1504   1522       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1534   1552       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1584       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1621   1649       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1725   1748       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      187    400       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      473    683       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      734    962       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      971   1176       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1180   1454       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1503   1758       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      391    436       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1976 AA;  225198 MW;  9E2D8F11624E971C CRC64;
     MAMLPPPGPQ SFVHFTKQSL ALIEQRIAER KSKEPKEEKK DDDEEAPKPS SDLEAGKQLP
     FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKTIFRF NATPALYMLS PFSPLRRISI
     KILVHSYPFQ NDSTLFSMLI MCTILTNCIF MTMSNPPDWT KNVDFRIIIS SFPFPARKWG
     IFIFPCYMYL TEFVNLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS VKKLSDVMIL
     TVFCLSVFAL IGLQLFMGNL KHKCVQNSLV NNETLESIMN TLESEEDFRK YFYYLEGSKD
     ALLCGFSTDS GQCPEGYTCM KIGRNPDYGY TSFDTFSWAF LALFRLMTQD YWENLYQQTL
     RAAGKTYMIF FVVVIFLGSF YLINLILAVV AMAYEEQNQA NIEEAKQKEL EFQQMLDRLK
     KEQEEAEAIA AAAAEYTSIR RSRIMGLSES SSETSKLSSK SAKERRNRRK KKNQKKLSSG
     EEKGDAEKLS KSDSEENIRR KSFHLGVEGH RRAHEKRLST PSQSPLSIRG SLFSARRSSR
     TSLFSFKGRG RDIGSETEFA DDEHSIFGDN ESRRGSLFVP HRPQERRSSN ISQASRSPPI
     LPVNGKMHSA VDCNGVVSLV DGRSALMLPN GQLLPEVIID KATSDDSGTT NQIHKKRRCS
     SYLLSEDMLN DPNLRQRAMS RASILTNTVE ELEESRQKCP PWWYRFAHKF LIWNCSPYWI
     KFKKCIYFIV MDPFVDLAIT ICIVLNTLFM AMEHHPMTEE FKNVLAIGNL VFTGIFAAEM
     VLKLIAMDPY EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT
     LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKIND DCTLPRWHMN
     DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ AMCLIVYMMV MVIGNLVVLN LFLALLLSSF
     SSDNLTAIEE DPDANNLQIA VTRIKKGINY VKQTLREFIL KTFSKKPKIS REIRQTEDLN
     TKKENYISNY TLAEMSKGHN FLKEKDKISG FGSCVDKYLM EDSDGQSFIH NPSLTVTVPI
     APGESDLENM NTEELSSDSD SEYSKVRLNQ SSSSECSTVD NPLPGEGEEA EAEPMNSDEP
     EACFTDGCVR RFSCCQVNIE SGKGKIWWNI RKTCYKIVEH SWFESFIVLM ILLSSGALAF
     EDIYIERKKT IKIILEYADK IFTYIFILEM LLKWIAYGYK TYFTNAWCWL DFLIVDVSLV
     TLVANTLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV NALIGAIPSI MNVLLVCLIF
     WLIFSIMGVN LFAGKFYECI NTTDGSRFPA SQVPNRSECF ALMNVSQNVR WKNLKVNFDN
     VGLGYLSLLQ VATFKGWTII MYAAVDSVNV DKQPKYEYSL YMYIYFVIFI IFGSFFTLNL
     FIGVIIDNFN QQKKKISQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN KIQGCIFDLV
     TNQAFDISIM VLICLNMVTM MVEKEGQSPY MTDVLYWINV VFIILFTGEC VLKLISLRYY
     YFTIGWNIFD FVVVIISIVG MFLADLIETY FVSPTLFRVI RLARIGRILR LVKGAKGIRT
     LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKKE DGINDMFNFE TFGNSMICLF
     QITTSAGWDG LLAPILNSKP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS YIIISFLVVV
     NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEYNKL SDFAAALDPP
     LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE SGEMDSLRSQ MEERFMSANP
     SKVSYEPITT TLKRKQEDVS ATVIQRAYRR YRLRQNVKNI SSIYIKDGDR DDDLLNKKDM
     AFDNVNENSS PEKTDATSST TSPPSYDSVT KPDKEKYEQD RTEKEDKGKD SKESKK
//
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