ID F7A9T8_MACMU Unreviewed; 935 AA.
AC F7A9T8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 2 {ECO:0000313|Ensembl:ENSMMUP00000036314.3};
GN Name=ITIH2 {ECO:0000313|Ensembl:ENSMMUP00000036314.3,
GN ECO:0000313|VGNC:VGNC:73794};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036314.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000036314.3, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036314.3,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000036314.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036314.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR AlphaFoldDB; F7A9T8; -.
DR Ensembl; ENSMMUT00000043317.3; ENSMMUP00000036314.3; ENSMMUG00000015954.4.
DR VEuPathDB; HostDB:ENSMMUG00000015954; -.
DR VGNC; VGNC:73794; ITIH2.
DR GeneTree; ENSGT00940000157945; -.
DR HOGENOM; CLU_008101_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 9.
DR Bgee; ENSMMUG00000015954; Expressed in liver and 13 other cell types or tissues.
DR ExpressionAtlas; F7A9T8; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..935
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169792"
FT DOMAIN 45..174
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 299..482
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 935 AA; 105051 MW; A5DB68DD176AF2F0 CRC64;
MKQLTCFFIC FFLSEVSGFE IPINGLSEFV DYEDLVELAP GKFRLVAENQ RYQEEADQVT
LYSYKVQSTI TSRMATTMIQ SKVVNNSPQP QNVVFDVQIP KGAFISNFSM TVDGTTFRSS
IKEKTVGRAL YAQARAKGKT AGLVRSRALD MENFRTEVNV LPGAKVQFEL HYQEVKWRKL
GSYEHRIYLQ PGRLAKHLEV DVWVIEPQGI RFLHVPDTFE GHFDGVPVIS KGQQKAHVSF
KPTVAQQRIC PNCRETVVDG ELVVLYDVKR EEKAGELEVF NGYFVHFFAP DNLDPIPKNI
LFVIDVSGSM WGVKMKQTVE AMKTILDDLR AEDHFSVIDF NQNVRTWRND LISATKTQVS
DAKRYIEKIQ PSGGTNINEA LLRAIFILNE ANNLGLLDPN SVSLIILVSD GDPTVGELKL
SKIQKNVKEN IQDNISLFSL GMGFDVDYDF LKRLSNENRG IAQRIYGNQD TSSQLKKFYN
QVSTPLLRNV QFNYPHTSVT DVTQNNFHNY FGGSEIVVAG KFDPAKLDQL ESIITATSAN
TQLVLETLAQ MDDLQDFLSK DKHADPDFTR KLWAYLTINQ LLAERSLAPT AAAKRRITRS
ILQMSLDHHI VTPLTSLVIE NEAGDERMLA DAPPQDPSCC SGALYYGSKV APDSIPSWAN
PSPTPVISML AQGAQVLEST PPPHVMRVEN DPHFIIYLPK SQKNICFNID SEPGKILNLV
SDPESGIVIN GQLVGAKKPN NGKLSTYFGK LGFYFQSEDV KIEISTEAIT LSGGSSTFAL
SWSDTAQVMN QRVQISVKKA KVVTITLDKE MSFSVLLHRV WKKHPINVDF LGIYVPPTNK
FSPNAHGLIG QFMQEPKIHI FNERPGKDPE KPEASMEVKG QKLIVTRGLQ KDYRTDLVFG
TDVTCWFVHN SGKGFIDGHY KDYFVPQLYS FLKRP
//