GenomeNet

Database: UniProt
Entry: F7A9T8_MACMU
LinkDB: F7A9T8_MACMU
Original site: F7A9T8_MACMU 
ID   F7A9T8_MACMU            Unreviewed;       935 AA.
AC   F7A9T8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 2 {ECO:0000313|Ensembl:ENSMMUP00000036314.3};
GN   Name=ITIH2 {ECO:0000313|Ensembl:ENSMMUP00000036314.3,
GN   ECO:0000313|VGNC:VGNC:73794};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036314.3, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000036314.3, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036314.3,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA   Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA   Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA   Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA   Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA   Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA   Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA   Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA   Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA   Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA   Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA   Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA   Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA   Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA   Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA   Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA   Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA   Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA   Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA   Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA   Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA   Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA   Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA   Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA   Kuhn R.M., Smith K.E., Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000036314.3}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036314.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   AlphaFoldDB; F7A9T8; -.
DR   Ensembl; ENSMMUT00000043317.3; ENSMMUP00000036314.3; ENSMMUG00000015954.4.
DR   VEuPathDB; HostDB:ENSMMUG00000015954; -.
DR   VGNC; VGNC:73794; ITIH2.
DR   GeneTree; ENSGT00940000157945; -.
DR   HOGENOM; CLU_008101_0_0_1; -.
DR   Proteomes; UP000006718; Chromosome 9.
DR   Bgee; ENSMMUG00000015954; Expressed in liver and 13 other cell types or tissues.
DR   ExpressionAtlas; F7A9T8; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..935
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030169792"
FT   DOMAIN          45..174
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          299..482
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   935 AA;  105051 MW;  A5DB68DD176AF2F0 CRC64;
     MKQLTCFFIC FFLSEVSGFE IPINGLSEFV DYEDLVELAP GKFRLVAENQ RYQEEADQVT
     LYSYKVQSTI TSRMATTMIQ SKVVNNSPQP QNVVFDVQIP KGAFISNFSM TVDGTTFRSS
     IKEKTVGRAL YAQARAKGKT AGLVRSRALD MENFRTEVNV LPGAKVQFEL HYQEVKWRKL
     GSYEHRIYLQ PGRLAKHLEV DVWVIEPQGI RFLHVPDTFE GHFDGVPVIS KGQQKAHVSF
     KPTVAQQRIC PNCRETVVDG ELVVLYDVKR EEKAGELEVF NGYFVHFFAP DNLDPIPKNI
     LFVIDVSGSM WGVKMKQTVE AMKTILDDLR AEDHFSVIDF NQNVRTWRND LISATKTQVS
     DAKRYIEKIQ PSGGTNINEA LLRAIFILNE ANNLGLLDPN SVSLIILVSD GDPTVGELKL
     SKIQKNVKEN IQDNISLFSL GMGFDVDYDF LKRLSNENRG IAQRIYGNQD TSSQLKKFYN
     QVSTPLLRNV QFNYPHTSVT DVTQNNFHNY FGGSEIVVAG KFDPAKLDQL ESIITATSAN
     TQLVLETLAQ MDDLQDFLSK DKHADPDFTR KLWAYLTINQ LLAERSLAPT AAAKRRITRS
     ILQMSLDHHI VTPLTSLVIE NEAGDERMLA DAPPQDPSCC SGALYYGSKV APDSIPSWAN
     PSPTPVISML AQGAQVLEST PPPHVMRVEN DPHFIIYLPK SQKNICFNID SEPGKILNLV
     SDPESGIVIN GQLVGAKKPN NGKLSTYFGK LGFYFQSEDV KIEISTEAIT LSGGSSTFAL
     SWSDTAQVMN QRVQISVKKA KVVTITLDKE MSFSVLLHRV WKKHPINVDF LGIYVPPTNK
     FSPNAHGLIG QFMQEPKIHI FNERPGKDPE KPEASMEVKG QKLIVTRGLQ KDYRTDLVFG
     TDVTCWFVHN SGKGFIDGHY KDYFVPQLYS FLKRP
//
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