GenomeNet

Database: UniProt
Entry: F7A9X6_MONDO
LinkDB: F7A9X6_MONDO
Original site: F7A9X6_MONDO 
ID   F7A9X6_MONDO            Unreviewed;      4695 AA.
AC   F7A9X6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSMODP00000016617};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSMODP00000016617};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000016617, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000016617, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000016617}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000016617}.
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DR   STRING; 13616.ENSMODP00000016617; -.
DR   Ensembl; ENSMODT00000016922; ENSMODP00000016617; ENSMODG00000013282.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F7A9X6; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002280; Chromosome 4.
DR   Bgee; ENSMODG00000013282; -.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4038   4061       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4235   4255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4306   4329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4495   4517       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4576   4599       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      598    806       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1472       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4695 AA;  527265 MW;  056EA6C6A90C7D8C CRC64;
     MGDGGEGEDD VQFLRTEDEV VLQCSATTLK EHIKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAVCCFVLE QSLSVRALQE MLANTVEAGT ESSQGGGHRT LLYGHAILLR HAHSRMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTM HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ ADASFMQTLW NMNPICSELI PSLPTGYVTG GHVLRLFHGH MDECLTISSA
     DSDDQRRLVH YEGGAVCTHA RSLWRLEPLR ISWSGSHLRW GQPLRVRHVT TGRYLALTED
     QGLIVVDAAK APTKATAFCF RVSKVPVEKL DTAPKRDVEG MGPPEIKYGE SLCFVQHVAS
     GLWLTYAAPD PKALRLGLMK RKAMLHQEGH MDDALSLTRC QLEESQAARM IYSTAGLYNQ
     FINGKPKGAA AAGVALPIEG VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
     EGMLTLVLNC IDRLNVYSTA AHFAEYAGEE AAESWKEIVN LLYELLASLI RGNRTNCALF
     SHNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLRECE WRHPPFRTLL PPLSISISLL PLSALCISFI LYLILYTSLP SIRPNIFVGR
     AEGTTQYGKW YFEVMVDSVE PFLTAQSTHL RVGWALTEGY SPYPGGGEGW GGNGVGDDLY
     SYGFDGLHLW SGRVARPVAS PGQHLLAAED VVSCCLDLSV PSISFRINGC PVQGVFEAFN
     LDGLFFPVVS FSAGIRVRFL LGGRHGEFKF LPPPGYAPCH EALLPRERLR LEPIKEYRRE
     GPHGPHLVGP TCCLSHTDFV PCPVDTVQIV LPPHLERIRE KLAENIHELW ALTRIEQGWT
     YGPVRDDNKR LHPCLVDFHN LPEPERNYNL QMSGETLKTL LALGCHVGMA DEKAEENLKK
     TKLPKTYMMS NRYKPAPLDL SHVKLTPAQT TLVDRLAENG HNVWARDRVG QGWSYSAVQD
     IPARRNPRLL GADDLAYVFN GHRVSTSCPP CPSPIFLNSA SFHLTCSPKE ESLFPHPSAE
     GRVMLSAWAS AERGKMGPRN YQGPSTTFLP SFLPLISILI PLSAFLQGQR WHMGSEPFGR
     PWQPGDVVGC MIDLTENNIL FTLNGEVLMS DSGSETAFKD IEIGDGFLPV CSLGLGQVGR
     LNLGQDVGSL RYFTICGLQE GFEPFAINMQ RPVTTWFSKS LPQFEPMPPD HPHYEVTRVD
     GTVDTPPCLR LTHRTWGSQN SLVEMMFLRL SLPVQFYQHF RYITMSETQT SEKAALRMGL
     FCHLLSASPS TLQYYYSVRV FAGQEPSSVW VGWVTPDYHQ YDMNFDLTKV RVVTVTMGDE
     RGNVHNSLKR SNCYMVWGGD FVSPGQQGRI SHTDMVIGCL VDLATGLMTF TANGKESNTF
     FQVEPNTKLF PAAFVLPTNQ NVIQFELGKL KNIMPLSAAM FLSERKNPAP QCPPRLEVQM
     LMPVSWSRMP NHFLQVETNR AGDRLGWAVQ CEDPLTMMAL HIPEENRCMD VLELSERLSL
     QRFHSHTLNL YRAVCALGNN RVAHALCSHV DQAQLLHAIE DAHLPGPLRA GYYDLLISIH
     LESACRSRRS MLNEYIVPLT PETSTITLFP PGPSADPGEE SPRRHGLPGV GTSTSLRPPL
     HFSPPCFVAA PEGAGTAEAP ARFSPSIPLE VLRDKALRML GEAVRDGGQH ARDPVGGSVE
     FQFVPVLKLV STLLVMGIFC DEDVKQILRM IEPEEGLLQM KLPESVKLQM CHLLEYFCDQ
     ELQHRVEALI AFSERYVDRL QGNQRCRYGL LMRAFTMSAA ETARRTREFR SPPQEQINML
     LHFKGGEDEE ECPVPDEVRQ ELLDFHQDLL LHCGIQLEGE EEEIEEETTL GSRLMNLLEK
     VKLVKKKEEE PEDSPAPEEK KPGEEKSCPE SLQELVSHTM VHWAQEDFIQ NPELVRAMFS
     LLHRQYDGLG ELLRALPRAY TISLSSVEDT MSLLESLCQI RSLLIVQMGP QEENLMIQSI
     GNIMNNKVFY QHPNLMRALG MHETVMEVMV NVLGGGESKE IRFPKMVTSC CRFLCYFCRI
     SRQNQRSMFD HLSYLLENSG IGLGMQGSTP LDVAAASVID NNELALALQE QDLEKVVSYL
     AGCGLQSCPM LLAKGYPDIG WNPGGGERYL DFLRFAVFVN GESVEENANV VVRLLIRRPE
     CFGPALRGEG GSGLLAAMEE AIRISEDPAR DGPGVRKDRR RDHHGEDAPE ENRVHLGNAI
     MSFYSALIDL LGRCAPETHL IQAGKGEALR IRAILRSLVP LDDLVGIISL PLQIPTLGKD
     GALVQPRMSA SFVPDHKAPM VLFLDRVYGI DSQDFLLHVL DVGFLPDMRA AASLDTVSDP
     LPTASSTAPL WRMCPDDSHQ RPLIPSSMEQ RLPYDKAESS EKKKESSLAK ASPTSPVRGR
     MKRSALIVPR ASSGRAPSSH LFGNKRLPCY LLPTHAPLLP KELFLGTKKY PAKPVHTLVP
     SALVVYQLPP QEVEGSFPPS PLKSPPLTPA LNRVLLLSVF YFMLLYKLFS DSGYFAWHHN
     TTPIQDSHMP FLWPPHIDSH IPSLWCPHRR LPYAFSLPPP YWKSPCKTPI YLLFALLSPV
     LSAPSLWAEH HHPTGGGTHP LLVPYDTLTA KEKARDREKA QELLKFLQMN GYAVTRGLKD
     MELDTSSIEK RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL
     PLINQYFNNH CLYFLSTPAK VLGSGGHASN KEKEMITSLI PLLPPLPHPQ ISLVLPWIPI
     ESTWVSIIQS DALPCSPRTV MKSGPEIVKA GLRSFFESAS EDIEKMVENL RLGKVSQART
     QVKGVGQNLT YTTVALLPVL TTLFQHIAQH QFGDDVILDD VQVSCYRTLC SIYSLGTTKN
     SYVEKLRPAL GECLARVAAA MPVAFLEPHL NEFNACSVYT TKSPRERAIL GLPSSVEEMC
     PDIPDLKQLM AEIGGLAESG ARYTEMPHVI EVTLPMLCNY LPRWWERGPE VPTSQPPGGP
     PPCTAVTSDH LNSLLGNILR IIVNNLGIDE ASWMKRLAVF AQPIVSRARP ELLRSHFIPT
     VGRLRKRAGK VVAEEEQLRL EAKAEAEEGE LLVRDEFSVL CRDLYALYPL LIRYVDNNRA
     HWLTEPNPDA EELFRMIAEI FIYWSKSHNF KREEQNFVVQ NEINNMSFLT ADSKSKMAKS
     GGSDQERTKK KRRGDRYSVQ TSLIVATLKK MLPIGLNMCA PTDQDLIALA KTRYALKDTD
     EEVREYLQNN LHLQGKSEGS PSLRWQMALY RGLPGREEDA DDPEKIVRRV QEVSAVLFHL
     EQVTEHPYKS KKAVWHKLLS KQRRRAVVAC FRMTPLYNLP RHRASNMFLE SYKAAWILTE
     EHSFEDRMID DLSVRWGPMG RGSPMAGHGG EESSIEVGMV IWQPFPNGIL GRYKLDEDYL
     YMAYADIMAK SCHLEEGEEA SEPAEEEVEA SFEEKEMEKQ RLLYQQARLH NRGAAEMVLQ
     MISACKGEPG AMVSSTLKLG ISILNGGNIE VQQKMLEYLK DKKEVGFFQS IQALMQTCSV
     LDLNAFERQN KAEGLGMVTE EGTVINRQNE ENVTPAVEFP QSLFTSLCCC CGEGLIHYFQ
     NYLRTQTGNT TTINIIICTV DYLLRLQESI SDFYWYYSGK DVIDEQGKRN FSKAMAVAKQ
     VFNSLTEYIQ GPCTGNQQSL AHSRLWDAVV GFLHVFAHMM MKLAQLALLS ILMGSRELLP
     GWPISHVVGS ILPTVNSFPS SILISPLSGP PSPLQFSSSQ TSSLFKACFM VAPHLPLHWA
     LFWACPPPPP FSAILHPGFH FSIFFSFIQH TPEDLCPGAP WGGDNEVLRL EGFFSSLAQW
     IFMPQNLPTT HYSGQRNQDL IRPQRAHVPN THRIPSQNHT SCLTLGLVSG SVTISQPLDR
     SLCLCICLPQ NQTLPLSTSY VHLSHCLSPL SDSPLLSSTL LSALDRKLLF RPIEVVSEWG
     KPGVFNFPFI IPFCVCTLLF VFKNSLVRCF FFVYSFSYLI IGRLRRMMGY VLDPIRHTLD
     YVDTQTDHRG YLHGMAGKQK EGIKIGGRKD LNNCPTDNWG RKQGWERILR ETGLDREEDI
     HRQRPTESSG MEGCREGMLV LQPSPEPEPE PEPEKADAEN GEKEGPQEPE PEPPKKAAAP
     SPPRKEDAKS EGPDFWEELE VQRVKFLNYL SRNFYTLRFL ALFLAFAINF ILLFYKVSDS
     PPGEEDLEGS GLEGLSGSGS GDFLGSGMGS GESTGYMEPA LRGLSILHTL IAFLCIIGYN
     CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD RLVLNTPSFP SNYWDKFVKR
     KVLEKHGDIF GRERIAELLG MDLASLEITA QNEKRPEPPS GLLTWIMSID VKYQIWKFGV
     IFTDNSFLYL IWYLVMSLLG HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG
     LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
     DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE DMETKCFICG
     IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE HTGQESYVWK MYQERCWDFF
     PAGDCFRKQY EDQLA
//
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