ID F7ABJ8_HORSE Unreviewed; 1778 AA.
AC F7ABJ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Plexin A2 {ECO:0000313|Ensembl:ENSECAP00000004125.3};
GN Name=PLXNA2 {ECO:0000313|VGNC:VGNC:21601};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000004125.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000004125.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004125.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000004125.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004125.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 9796.ENSECAP00000004125; -.
DR PaxDb; 9796-ENSECAP00000004125; -.
DR Ensembl; ENSECAT00000005858.3; ENSECAP00000004125.3; ENSECAG00000001716.4.
DR VGNC; VGNC:21601; PLXNA2.
DR GeneTree; ENSGT01050000244850; -.
DR InParanoid; F7ABJ8; -.
DR OMA; CMEGKSH; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000001716; Expressed in synovial membrane of synovial joint and 19 other cell types or tissues.
DR ExpressionAtlas; F7ABJ8; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002116; C:semaphorin receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IBA:GO_Central.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IBA:GO_Central.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd11272; Sema_plexin_A2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR042826; Plexin-A2_sema.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1251..1275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..523
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1279..1306
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1778 AA; 198337 MW; 4C3FEFC695777A25 CRC64;
MRAQRICLLV LAPLRMEQRR PWPRAAEVDS WSVVLLSVVW VMLAPQAVSM PQFSTFHSEN
RDWTFNHLTV HRGTGAVYVG AINRVYKLTG NLTIQVAHKT GPEEDNKSCY PPLIVQPCSE
VLTLTNNVNK LLIIDYSENR LLACGSLYQG VCKLLRLDDL FILVEPSHKK EHYLSSVNKT
GTMYGVIVRS EGEDGKLFIG TAVDGKQDYF PTLSSRKLPR DPESSAMLDY ELHSDFVSSL
IKIPSDTLAL VSHFDIFYIY GFASGGFVYF LTVQPETPEG VAINSAGDLF YTSRIVRLCK
DDPKFHSYVS LPFGCTRAGV EYRLLQAAYL AKPGDSLAQA FNISSQDDVL FAIFSKGQKQ
YHHPPDDSAL CAFPIRAINL QIKERLQSCY QGEGNLELNW LLGKDVQCTK APVPIDDNFC
GLDINQPLGG STPVEGLTLY TTSRDRMTSV ASYVYNGYSV VFVGTKSGKL KKIRADGPPH
GGVQYEMVSV LKDGSPILRD MAFSIDQRYL YIMSERQITR VPVESCEQYT TCGECLSSGD
PHCGWCALHN MCSRRDKCQR AWEPNRFAAS ISQCMSLEVH PSSISVSEHS RLLSLLVSDA
PDLSAGIACA FGNLTEVEGQ VSGSQVICIS PGPKDVPIIP LDQDWFGLEL QLRSKETGKI
FVSTEFKFYN CSAHQLCLSC VNSAFRCHWC KYRNLCTHDP TTCSFQEGRI NISEDCPQLV
PTEEILIPVG EVKPITLKAR NLPQPQSGQR GYECVLNIQG AIHRVPALRF NSSSVQCQNS
SYQYDGMDIS NLAVDFAVVW NGNFIIDNPQ DLKVHLYKCA AQRESCGLCL KADRKFECGW
CSGERRCTLH QHCTSPSSPW LDWSSHNVKC SNPQITEILT VSGPPEGGTR VTIHGVNLGL
DFSEIAHHVQ VAGVPCTPLP GDYIIAEQIV CEMGHALVGT TSGPVRLCIG ECKPEFMTKS
HQQYTFVNPS VLSLNPIRGP ESGGTMVTIT GHYLGAGSSV AVYLGNQTCE FYGRSMNEIV
CVSPPSSNGL GPVPVSVSVD RARVDNNLQF EYIDDPRVQR IEPEWSIASG HTPLTITGFN
LDVIQEPRIR VKFNGKESVN VCKVVNTTTL TCLAPSLTTD YRPGLDTVER PDEFGFVFNN
VQSLLIYNDT KFIYYPNPTF ELLSPTGVLD QKPGSPIILK GKNLCPPASG GAKLNYTVLV
GETPCAVTVS ETQLLCEPPN LTGQHKVMVH VGGMVFSPGS VSVISDSLLT LPAIVSIAAG
GSLLLIIVII VLIAYKRKSR ENDLTLKRLQ MQMDNLESRV ALECKEAFAE LQTDINELTS
DLDRSGIPYL DYRTYAMRVL FPGIEDHPVL RELEVQGNGQ QHVEKALKLF AQLINNKVFL
LTFIRTLELQ RSFSMRDRGN VASLIMTGLQ GRLEYATDVL KQLLSDLIDK NLENKNHPKL
LLRRTESVAE KMLTNWFAFL LHKFLKECAG EPLFMLYCAI KQQMEKGPID AITGEARYSL
SEDKLIRQQI EYKTLILNCV NPDNENSPEI PVKVLNCDTI TQVKEKILDA VYKNVPYSQR
PRAVDMDLEW RQGRIARVVL QDEDITTKIE GDWKRLNTLM HYQVSDRSVV ALVPKQTSSY
NIPASASISR TSISRYDSSF RYTGSPDSLR SRAPMITPDL ESGVKVWHLV KNHDHGDQKE
GDRGSKMVSE IYLTRLLATK GTLQKFVDDL FETLFSTVHR GSALPLAIKY MFDFLDEQAD
RHSIHDTDVR HTWKSNWSRE NAFSDYKFLS CRRNSPND
//
