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Database: UniProt
Entry: F7ADR2_MACMU
LinkDB: F7ADR2_MACMU
Original site: F7ADR2_MACMU 
ID   F7ADR2_MACMU            Unreviewed;      1980 AA.
AC   F7ADR2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   05-JUL-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSMMUP00000000558};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000000558, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000000558, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000000558,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000000558}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000000558};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000000558}.
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DR   EMBL; JSUE03006786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03006787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03006788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03006789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03006790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000000607; ENSMMUP00000000558; ENSMMUG00000000415.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000006718; Chromosome 11.
DR   Bgee; ENSMMUG00000000415; -.
DR   ExpressionAtlas; F7ADR2; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    103    121       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    152       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    200    220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    255    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    755    773       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    785    803       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    865    893       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    952    978       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1200   1218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1239   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1270   1293       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1314   1342       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1465       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1523   1541       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1553   1571       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1583   1603       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1640   1668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1743   1766       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      500    703       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      755    982       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      992   1193       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1198   1473       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1522   1776       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      412    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1980 AA;  225566 MW;  1D1253B22E7A3EFB CRC64;
     MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED SKPKPNSDLE
     AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     IRRIAIKILI HSYPFLMIIM CTILTNCVFM TFSNPPDWSK NVEYTFTGIY TFESLVKIIA
     RGFCIDGFTF LRDPWNWLDF SVIMMAYITE FVNLGNVSAL RTFRVLRALK TISVIPGLKT
     IVGALIQSVK KLSDVMILTV FCLSVFALIG LQLFMGNLRN KCVVWPINFN ESYLENGTKG
     FDWEEYINNK TNFYTVPGML EPLLCGNSSD AGQCPEGYQC MKAGRNPNYG YTSFDTFSWA
     FLALFRLMTQ DYWENLYQLT LRAAGKTYMI FFVLVIFVGS FYLVNLILAV VAMAYEEQNQ
     ATLEEAEQKE AEFKAMLEQL KKQQEEAQAA AMATSAGTVS EDAIEEEGEE GGGSPRSSSE
     ISKLSSKSAK ERRNRRKKRK QKELSEGEEK GDPEKVFKSE SEDGMRRKAF RLPDNRIGRK
     FSIMNQSLLS IPGSPFLSRH NSKSSIFSFR GPGRFRDPGS ENEFADDEHS TVEESEGRRD
     SLFIPIRARE RRSSYSGYSG YSQGSRSSRI FPSLRRSVKR NSTVDCNGVV SLIGGPGSHI
     GGRLLPEAAT DDSVRKNKNR SRLVSMDQLA SYGRKDRINS IMSVVTNTLV EELEESQRKC
     PPCWYKFANT FLIWECHPYW IKLKEIVNLI VMDPFVDLAI TICIVLNTLF MAMEHHPMTP
     QFEHVLAVGN LVFTGIFTAE MFLKLIAMDP YYYFQEGWNI FDGFIVSLSL MELSLADVEG
     LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK
     SYKECVCKIN QDCELPRWHM HDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QAMCLIVFMM
     VMVIGNLVVL NLFLALLLSS FSADNLAATD DDGEMNNLQI SVIRIKKGVA WTKLKVHAFM
     QAHFKQREAD EVKPLDELYE KKANCIANHT GADIHRNGDF QKNGNGTTSG IGSSVEKYII
     DEDHMSFINN PNLTVRVPIA VGESDFENLN TEDVSSESDP EGSKDKLDDT SSSEGSTIDI
     KPEVEEVPVE QPEEYLDPDA CFTEGCVQRF KCCQVNIEEG LGKSWWILRK TCFLIVEHNW
     FETFIIFMIL LSSGALAFED IYIEQRKTIR TILEYADKVF TYIFILEMLL KWTAYGFVKF
     FTNAWCWLDF LIVAVSLVSL IANALGYSEL GAIKSLRTLR ALRPLRALSR FEGMRVVVNA
     LVGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKYHYCFNE TSEIRFEIED VNNKTECEKL
     MEGNNTEIRW KNVKINFDNV GAGYLALLQV ATFKGWMDIM YAAVDSRKPD EQPKYEDNIY
     MYIYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKIGQDIF MTEEQKKYYN AMKKLGSKKP
     QKPIPRPLNK IQGIVFDFVT QQAFDIVIMM LICLNMVTMM VETDTQSKQM ENILYWINLV
     FVIFFTCECV LKMFALRHYY FTIGWNIFDF VVVILSIVGM FLADIIEKYF VSPTLFRVIR
     LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIFSIFGM SNFAYVKHEA
     GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LLPILNRPPD CSLDKEHPGS GFKGDCGNPS
     VGIFFFVSYI IISFLIVVNM YIAIILENFS VATEESADPL SEDDFETFYE IWEKFDPDAT
     QFIEYCKLAD FADALEHPLR VPKPNTIELI AMDLPMVSGD RIHCLDILFA FTKRVLGDSG
     ELDILRQQME ERFVASNPSK VSYEPITTTL RRKQEEVSAV VLQRAYRGHL ARRGFICKKT
     TSNKLENGGT HREKKESTPS TASLPSYDSV TKPEKEKQQR AEEGRRERTK RQKEVRESKC
//
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