ID F7AFK0_ORNAN Unreviewed; 690 AA.
AC F7AFK0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=F-box/LRR-repeat protein 5 {ECO:0000256|ARBA:ARBA00020540};
DE AltName: Full=F-box and leucine-rich repeat protein 5 {ECO:0000256|ARBA:ARBA00030695};
GN Name=FBXL5 {ECO:0000313|Ensembl:ENSOANP00000017217.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017217.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017217.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017217.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000017217.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017217.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7AFK0; -.
DR STRING; 9258.ENSOANP00000017217; -.
DR Ensembl; ENSOANT00000017220.3; ENSOANP00000017217.3; ENSOANG00000010867.3.
DR eggNOG; ENOG502QS5I; Eukaryota.
DR GeneTree; ENSGT00390000006172; -.
DR HOGENOM; CLU_017503_0_0_1; -.
DR InParanoid; F7AFK0; -.
DR OMA; GEMFCGH; -.
DR OrthoDB; 2913997at2759; -.
DR TreeFam; TF331105; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002279; Chromosome 4.
DR Bgee; ENSOANG00000010867; Expressed in endometrium and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:Ensembl.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd22118; F-box_FBXL5; 1.
DR CDD; cd12109; Hr_FBXL5; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.20.120.520; nmb1532 protein domain like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR045808; Hr_FBXL5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR13318:SF19; F-BOX_LRR-REPEAT PROTEIN 5; 1.
DR PANTHER; PTHR13318; UNCHARACTERIZED; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF01814; Hemerythrin; 1.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 4.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 202..248
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 570..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 77873 MW; B38DACA2922066EC CRC64;
MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNSDF RALLQSLYAT FKEFKMHEQI
ENEYIIGLLQ QRSRTVYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT
RDFLPHMKEE EEVFQPMLME YFTYEELKDI KKKVIAQHCS HKDTAELLRG LSLWNQAEER
QKVFKYSVDE KSDKETEVIE HTTNITHLPP EVMLAIFSYL NPQELGRCSQ VSTKWSQLTK
TGSLWKHLYP VHWARGDWYS GPPTELDTEP DEDWVKNRKD ESRAFQEWDE DADIDESEES
VEESIAINIA QTEKRLLHGL IHNILPHVGT SVKTVVLAYS SAVSSKMVRQ ILELCPNLEH
LDLTQTAISD SAFDSWSWLG CCQNLRHLDL SGCEKITDAA LEKISRALGV LTSHKKGVLK
ICRSKGAAPT WKNKDIAIQP SKKYACLHDL TNESLVRGAD NEHHWSKPVT SENLNSAYVW
MLDAEDLADI EDAVEWRHRS VEGLCVMETA SGLCSSAGCY SKDIIGLRTS VCWQQHCASP
ALTYCGHAFC SAGTALRTIR ALPEPSALGK IAPRTRRSEG KDSIHSGSEN SDQETGRVLL
FLSLSGCYQI TDHGLRVLTL GGGLPHLEHL NLSGCLTVTG AGLQDLVSAC PSLNDEHFYY
CDNINGPHAE TASGCQNLQC GFRACCRSGE
//
