ID F7AN09_HORSE Unreviewed; 2452 AA.
AC F7AN09;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Zinc finger FYVE domain-containing protein 26 {ECO:0000256|ARBA:ARBA00014373};
GN Name=ZFYVE26 {ECO:0000313|Ensembl:ENSECAP00000016062.3,
GN ECO:0000313|VGNC:VGNC:25230};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016062.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016062.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016062.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016062.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016062.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphatidylinositol 3-phosphate-binding protein required for
CC the abcission step in cytokinesis: recruited to the midbody during
CC cytokinesis and acts as a regulator of abcission. May also be required
CC for efficient homologous recombination DNA double-strand break repair.
CC {ECO:0000256|ARBA:ARBA00025209}.
CC -!- SUBUNIT: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with
CC TTC19 and KIF13A. {ECO:0000256|ARBA:ARBA00025962}.
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DR Ensembl; ENSECAT00000019613.4; ENSECAP00000016062.3; ENSECAG00000017584.4.
DR VGNC; VGNC:25230; ZFYVE26.
DR GeneTree; ENSGT00920000149143; -.
DR HOGENOM; CLU_228199_0_0_1; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000017584; Expressed in retina and 23 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR CDD; cd15724; FYVE_ZFY26; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR PANTHER; PTHR46591:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1725..1785
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 610..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1789..1809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..776
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1789..1808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2452 AA; 273747 MW; F2CDBD9E8A9B974E CRC64;
MHHPFGKEET ASQKQLFGFF CECLRRGEWE LAQACVPQLH EAQGDIPKKV EDILQALVVC
PNQLRCGQDI NPQRLAWVWL LVLETWLGEK KLLPTVLRRK LEFLLLSEDF QGDIPEDILK
ELYEVLAQDT VGPGLDGNQR QENRTPQLSL EAVSVLWDLL RQAPQPAQAL LELLLRENDG
TGLCGWRLQK ALVDLIQKAL RALQGPAAGP PGVVDAIYGA LRTLHCPVEP LGLELRTLCE
ELLEACRSEG SPLQEERLLS CLLHRAGQGL VSLYGHIYAE KATEKPQKTK PSGKVSPDHL
DPERAMLVLF SNADPAQAWK LAYFYCLSNS KHFLEQILVT ALTLLKEEDF PSLGSLLDRE
FKPLSRLLVL LGWTHCQSLA AAKRLLQTLH RTQDQGCDKL LRDACDGLWA HLEVLEWCVQ
QSSNPIPKRD LLCHLHGGDS HSVLYSLHHL TNLPALREED VLKLLQKVPA RDPQQQHDSA
DTLAPEHLSQ CQNLTLYRSF CAMKYAIYAL CVNSHQHSQC QECKDSPSED LASAVEPTSD
ALPSPGASRL FSTYLARCQQ YLCSIPDSLC LELLENIFSL LLLTSADLHP EPHLPEDYAE
DDDIEAKGQL GLRSPSESPQ HIAQPERKSE RASLGVPRSL PCTIPSCLKT EPKDSSPGPQ
GHSFLDLKHF TSGITGFLAD EFAIGAFLRL LQEQLDELSS HNLPENPKLL EGQSCSGSRD
GLPSRLHRFS KVVSEAQWRY KVVTSNQGSE EQPSRRYRPV ATRHPSLRRG RRTRRSRADG
RDRGSNPSLE STSSDLSTST SEGSLSTVSG RNELDGRLQP QPQSSLIPMM FSPPESLLAS
CILRGNFAEA HQVVFMFNLK SSPSSGELMF VERYQEVIQE LARVEHKIEN QNSDGGSSTI
RRTGSGRSTL QAIGSAAAAG RRLDHVLLNA DGIRGFPVVL QQISKILNYP LVSAGQTKSE
SVEEKGGSLP RCSIAELLQM CWPSLTEDCV ASHTTHSQQL DQVLQSLREA LELPEPRSTP
LSSLVEQVAQ KVLEAENHPV HIQTQLLQKN LGKHTPAGSR QTDYLGTFFS YCSTLAAVLL
RSLSSEPDRV EVKVGNPFVL LQQSSSQLVS HLLLERQVPP DRLAALLAQE GLGLSVPQVI
VNCCCEPLAL CSSRQSQQTS SLLTHLGTLA QLHTSHCLED LPLSTLSSPK PTENPTLERK
SHSSPRGSSP PALTSSALAF LKSRSKLLAT VACLGVSWGA KVTKPSLSWK ELRGRREVPL
TAEQVARECE RLLEQFPMLE ASLMAAWEPL QGSSEQGQSL AASLCGQASL STVLLGLHSP
TALDVLTEAF EEALVARDWP RALQLTEVYG RDVDDLNSIR DAVLSCAAAY DKEGWQYLFA
VKDASLRSRL TLQFVNRWPL ESCLEILAYC ISDIAVQDAL KCELRRKLAE LQVYQKILGL
QDTPVWCDWQ TLRNCCVEDP STVMNMILEA KEYGLCEEWG CLYPIPREHL ISLHQKHLLH
LLEKGDHEKA LKLLQRIPDP TMCLEVTEQS LDQHPSLATS HFLANYLTTH FYGELTAARH
REIQALYMGS KVLLTLPEQH RASYSHLSSN PLLMLEQLLM NMKVDWATVA VQTLHQLLAG
QEIGFSTDEV DSLLSRYAGK ALDFPYPLRE KRSDSVSHLQ EAVSQASDLE TLSRSPSAEF
LSAAAPGVSI VHSPSPRERS LPQSQPPLEF VPPATPPARH QWVPDESKSI CMVCCREHFT
MFNRRHHCRR CGRLVCNSCS TKKMVVEGCR ENPARVCDQC YSYYNKDVSE ENPGQPEVPD
SSKTESPPYS AVVRVPKAAE VEWILDLNEE ENELVRSEFY YEQAPNASLC IAILNLHRDC
AACGHQLIEH CCRLSQGLTN PEVDAGLLID IMKQLLFSAK MMFVKAGRSQ DLALCDSYIS
KVDVLNILVA AAYRHVPSLD QILQPAAVTR LRNQLLEAEY YQLGVEVSTK TGLDTTGAWH
AWGMACLKAG NLAAAREKFS RCLKPPFDLN QLSQGSRLVQ DVVEYLESTA RPLLSLQDDD
YFATLKELEA TLRTQSLSLE VIPEGKIMNN TYYQECLFYL HNYSTNLAIV GFYVRHSCLR
EALLHLLSKE SPPEVFIEGI FQPSYKSGKL HTLENLLESI DPTLESWGKY LIAACQHLQK
KNYYHILYEL QQFMKDQVRA AMTCIRFFSH KAKTYTELGE KLSWLLKAKD HLKIYLQETS
HGTRRKKTTF FRKKMTAADV SRHMNTLQLQ MEVTRFLHRC ESAGTAQITT LPLPTLFGNN
HMKMDVACKV MLGGKNVEDG FGIAFRVLQD FQLDAAMTYC RAARQLVERE KYSEIRQLLK
CVSESGMAAK SDGDTILLNC LEAFKRIPPQ ELEGLIQAIH NDDNKVQAYL TCCKLRSAYL
IAVKQEHSRA TVLVQQVQQA AKSSGDAVVQ DICTQWLLTS HTRGAHGPSS RK
//
