ID F7AR09_CALJA Unreviewed; 1143 AA.
AC F7AR09;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Integrin subunit alpha 1 {ECO:0000313|Ensembl:ENSCJAP00000042253.4};
GN Name=ITGA1 {ECO:0000313|Ensembl:ENSCJAP00000042253.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000042253.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000042253.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000042253.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; F7AR09; -.
DR Ensembl; ENSCJAT00000061507.4; ENSCJAP00000042253.4; ENSCJAG00000001502.5.
DR GeneTree; ENSGT00940000157646; -.
DR HOGENOM; CLU_004111_5_0_1; -.
DR OMA; THTFLAI; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000001502; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1106..1133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 1..55
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 136..319
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 440..502
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 521..579
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 583..643
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1143 AA; 126814 MW; 29FA6E226937435C CRC64;
MTFSGPVEDM FGYTVQQYEN EEGKWVLIGS PLVGQPKNRT GDVYKCPVGR GKSLPCVKLD
LPVNTSIPDV TEVKENMTFG STLVTNPNGG FLACGPLYAY RCGHLHYTTG ICSDVSPTFQ
VVNSIAPVRE CSTQLDIVIV LDGSNSIYPW DSVTAFLNDL LERMDIGPKQ TQVGIVQYGE
NVTHEFNLNK YSSTEEVLVA AKKIVQRGGR QTMTALGIDT ARKEAFTEAR GARRGVKKVM
VIVTDGESHD NHRLKKVIQD CEDENIQRFS IAILGSYNRG NLSTEKFVEE IKSIASEPTE
KHFFNVSDEL ALVTIVKTLG ERIFALEATA DQSAASFEME MSQTGFSAHY SQDWVMLGAV
GAYDWNGTVV MQKADKIIIP QNTTFNVEST KMNEPLASYL GYTVNSATAA AGDVLYIAGQ
PRYNHTGQVI IYRMEDGNIK ILQTLSGEQI GSYFGSILTT IDIDKDSNTD ILLVGAPMYM
GTEKEEQGKV YVYALNQTRF EYQMSLEPIK QTCCSSQQRN SCKKQNKNEP CGARFGTAIA
AVKDLNLDGF NDIVIGAPLE DDHGGAVYIY HGSGKTIRKE YAQRIPSGGD GKTLKFFGQS
IHGEMDLNGD GLTDVTIGGL GGAALFWSRD VAVVKVAMNF EPNKVNIQKK NCRMEGKETV
CINATVCFDV KLKSKEDTIY EADLQYRVIL DSLRQISRSF FSGTQERKVQ RNITVRKSEC
TKHSFYMLDK HDFQDSVRIT LDFNLTDPEN GPVLDDSLPN SVHEYIPFAK DCGNKGKCIS
DLSLNVTTTE KDLLIVRSQN DKFNISITVK NTKDSAYNTR TIVHYSPNLV FSGIEAIQKD
SCESNHNITC KVGYPFLRRG EMVTFKILFQ FNTSFLMENV TIHLSATSDS EEPPETLSDN
VVNISIPVKY EVGLQFYSSA SEYHISIAAN ETVPEVINST EDIGNEINIF YLIRKSGYFP
MPELKLSISF PNMTSNGYPV LYPTGVSSSD NAKCRPHISE DSFSINSGKK LITSTDHLKQ
GTILDCSTCK FATITCNLIP SDMSQVNVSL ILWKPTFIKS YFSSLNLTIT GELQSENTSL
VLSSSNQKRE LAIQISKDGL PGRVPLWVIL LSAFAGLLLL MLLILALWKI GFFKRPLKKK
MEK
//
