ID F7AVY8_HORSE Unreviewed; 1372 AA.
AC F7AVY8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=MSH6 {ECO:0000313|Ensembl:ENSECAP00000004388.3,
GN ECO:0000313|VGNC:VGNC:51368};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000004388.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000004388.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004388.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000004388.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004388.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR STRING; 9796.ENSECAP00000004388; -.
DR PaxDb; 9796-ENSECAP00000004388; -.
DR Ensembl; ENSECAT00000006218.3; ENSECAP00000004388.3; ENSECAG00000005949.4.
DR VGNC; VGNC:51368; MSH6.
DR GeneTree; ENSGT00550000075024; -.
DR HOGENOM; CLU_002472_1_3_1; -.
DR InParanoid; F7AVY8; -.
DR OMA; TPMMAQY; -.
DR TreeFam; TF105842; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000005949; Expressed in inner cell mass and 23 other cell types or tissues.
DR ExpressionAtlas; F7AVY8; baseline.
DR GO; GO:0032301; C:MutSalpha complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd05837; PWWP_MSH6; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF00855; PWWP; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 104..166
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1372 AA; 154322 MW; 173D01515F6503AD CRC64;
MPTRPRSGPQ GKVAPPPLPP GPPLPPAGMR PGARRGLGPG PWRAPRRRLR RGTSTEGCGG
RQQLRSPPGR WAGDAGRRRR HGGGAHAVGE GRPRARRSSC DFSPGDLVWA KMEGYPWWPC
LVYNHPFDGT FIREKGKSVR VHVQFFDDSP TRGWVSKRLL KPYTGSKSKE AQKGGHFYSA
KPEILRAMQR ADEALNKDKI KRLELAVCDE PSEPEEEEME VGATYASDKS EEDNEIDSEE
EVPPKVQGSR RSSRQIKKRR VISDSESDIG GSDVEFKPDA KEEGSSDEIS SGVGDSDSEG
LDSPVKVVPK RKRMVTGNGS LKKKTSRKEM PSATKRATSI SSETKSTLSA FSAPQNSESQ
AHVSGGCDDG SRPTIWYHET LEWLKEEKRR DLHRRRRDHP DFDASTLYVP EDFLNSCTPG
MRKWWQIKSQ NFDLVIFYKV GKFYELYHMD ALIGVSELGL VFMKGNWAHS GFPEIAFGRY
SDSLVQKGYK VARVEQTETP EMMEARCRKM AHISKHDRVV RREICRVITK GTQTYSVLEG
DPSENYSKYL LSLKEKDDDS SGHSRVYGVC FVDASLGKFF IGQFSDDRHC SRFRTLVAHY
PPVQVLFEKG NLSMETKMIL KGSLSSSLQE GLIPGSQFWD AAKTLRTLLE EGYFTEKLNE
DSGVMLPQVL KDMTSESDSV GLTPGEKSEL ALSALGGCVF YLKKCLIDQE LLSMANFEEY
IPLDSDMVSA TRPGAVFTKA NQRMVLDAVT LNNLEIFLNG TNGSTEGTLL EKIDTCHTPF
GKRLLKQWLC APLCSPYAIN DRLDAIEDLM VVPDKISEVV DLLKKLPDLE RLLSKIHNVG
SPLKSQNHPD SRAIMYEETT YSKKKIIDFL SALEGFKVIC KIIGIMEEVV DDFKSKILKQ
VITLQTKNPE GRFPDLTIEL NRWDTAFDHE KARRTGLITP KAGFDSDYDQ ALADIRENEQ
SLLEYLEKQR SRIGCRTIVY WGIGRNRYQL EIPENFITRN LPEEYELKST KKGCKRYWTK
TIEKKLANLI NAEERRDVSL KDCMRRLFYN FDKNYKDWQA AVECIAVLDV LLCLANYSRG
GDGPMCRPLI LLPEEDTPPF LYLKGSRHPC ITKTFFGDDF IPNDILIGCE EEEEENGKAY
CVLVTGPNMG GKSTLMRQAG LLAVMAQMGC YVPAEVCRLT PIDRVFTRLG ASDRIMSGES
TFFVELSETA SILTHATAHS LVLVDELGRG TATFDGTAIA NAVVKELAEN IKCRTLFSTH
YHSLVEDYSQ NVAVRLGHMA CMVENECEDP SQETITFLYK FIKGACPKSY GFNAARLANI
PEEVIQKGHR KAREFEKMTQ SLRLFREVCL ASERSSVDAE GVHKLLTLIQ EL
//
