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Database: UniProt
Entry: F7B2E9_ORNAN
LinkDB: F7B2E9_ORNAN
Original site: F7B2E9_ORNAN 
ID   F7B2E9_ORNAN            Unreviewed;       912 AA.
AC   F7B2E9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   30-AUG-2017, entry version 45.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSOANP00000016625};
GN   Name=TRPC6 {ECO:0000313|Ensembl:ENSOANP00000016625};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016625, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000016625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016625};
RX   PubMed=8919867; DOI=10.1007/BF02198841;
RA   Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
RT   "The mitochondrial genome of a monotreme--the platypus
RT   (Ornithorhynchus anatinus).";
RL   J. Mol. Evol. 42:153-159(1996).
RN   [2] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [3] {ECO:0000313|Ensembl:ENSOANP00000016625}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016625};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016625}.
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DR   STRING; 9258.ENSOANP00000016625; -.
DR   Ensembl; ENSOANT00000016628; ENSOANP00000016625; ENSOANG00000010492.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; F7B2E9; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000010492; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0036057; C:slit diaphragm; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0032414; P:positive regulation of ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005462; TRPC6_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF69; PTHR10117:SF69; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01647; TRPCHANNEL6.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    390    410       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    422    445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    574    595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    684    705       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       87    137       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      200    232       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      200    232       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      865    900       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   912 AA;  104472 MW;  E32DA2D294ACE95A CRC64;
     MDPPGPYRPG RPRNDSQDYL LIDSELGDQA QPQGYHPAGR GTESRLAHRR QTILREKGRR
     LANRGPAYMF SDRSTSLSIE EERFLDAAEY GNIPVVRKML EECLSLNVNC VDYMGQNALQ
     LAVANEHLEI TELLLKKENL SRVGDALLLA ISKGYVRIVE AILNHPAFAE GKRLATSPSQ
     SEIQLDDFYA YDEDGTRFSH DVTPIILAAH CQEYEIVHTL LRKGARIERP HDYFCKCSEC
     NQKQKNDSFS HSRSRINAYR GLASPAYLSL SSEDPVMTAL ELSNELAVLA NIEKEFKNDY
     KKLSVQCKDF VVGLLDLCRN TEEVEAILNG DVKMNPHGGK QGRPSLSRLK MAIKYEVKKF
     VAHPNCQQQL LSIWYENLSG LRQQTMAVKF LVVLAVAVGL PFLAMVYWIA PCSKLGKIMR
     GPFMKFVAHA ASFTIFLGLL VMNAADRFEG TSLRPNETKT DDSRQLFRMK TSCFSWMEML
     IISWVIGMIW SECKEIWSQG PREYLFELWN MLDFGMLAIF AASFIARFMA FWHASRAQKY
     VDENMTDLTA ASLEENIKYY TLARIKWDPS DPQIISEGLY AIAVVLSFSR IAYILPANES
     FGPLQISLGR TVKDIFKFMV IFIMVFVAFM IGMFNLYSYY LGAKQNEAFT TVEESFKTLF
     WAIFGLSEVK SVVINYNHKF IENIGYVLYG VYNVTMVIVL LNMLIAMINS SFQEIEDDAD
     VEWKFARAKL WFSYFEEGRT LPVPFNLVPS PKSLFYLLLR IKKWISELFR GCKKGFREDA
     EMNKRNEEKK IGKLGSNEEL ANLSLDKKQL GHRKQSSIRS SEDLHLNSLN NPPGQYQKIM
     KRLIKRYVLK AQVDKESDEV NEGELKEIKQ DISSLRYELL EEKSQNTEDL AELIRKLGEK
     LSIDSNQEES KR
//
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