ID F7B793_XENTR Unreviewed; 371 AA.
AC F7B793;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
GN Name=pou4f1 {ECO:0000313|Ensembl:ENSXETP00000038616,
GN ECO:0000313|RefSeq:XP_002931972.1,
GN ECO:0000313|Xenbase:XB-GENE-853139};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000038616};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000038616}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000038616};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000038616}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002931972.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002931972.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002931972.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family.
CC {ECO:0000256|RuleBase:RU361194}.
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DR RefSeq; XP_002931972.1; XM_002931926.5.
DR Ensembl; ENSXETT00000038616; ENSXETP00000038616; ENSXETG00000017814.
DR GeneID; 100488759; -.
DR KEGG; xtr:100488759; -.
DR AGR; Xenbase:XB-GENE-853139; -.
DR CTD; 5457; -.
DR Xenbase; XB-GENE-853139; pou4f1.
DR eggNOG; KOG1168; Eukaryota.
DR HOGENOM; CLU_013065_0_0_1; -.
DR OMA; AHSHMHG; -.
DR OrthoDB; 4250502at2759; -.
DR TreeFam; TF316413; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000017814; Expressed in 2-cell stage embryo and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR PANTHER; PTHR11636:SF42; POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transcription {ECO:0000256|RuleBase:RU361194}.
FT DOMAIN 212..289
FT /note="POU-specific"
FT /evidence="ECO:0000259|PROSITE:PS51179"
FT DOMAIN 305..365
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 307..366
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 91..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 39913 MW; 6100A0AC6A2BB61A CRC64;
MMSMNSKQPH FAMHPSLPEH KYTSLHSSSE AIRRACLPTP PMQSNIFASL DETLLARAEA
LAAVDIAVSQ GKSHPYKPDA TYHTMNSVQC SNNSSVPLGP HHHHHHHHHH HQALEPGDLL
EHVASPSLAL MASTGHEGVG GGGGGGGGGG GLMSSPGHHH SHMHGLSHLS HQAAMNMTSA
LQHPGLVAAH HGPGGQVASA VGAAAGLASI CDSETDPREL EAFAERFKQR RIKLGVTQAD
VGSALANLKI PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKLNKPE
LFNGGEKKRK RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ
KQKRMKFSAT Y
//
