ID F7BD49_HORSE Unreviewed; 523 AA.
AC F7BD49;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Neuropilin and tolloid like 2 {ECO:0000313|Ensembl:ENSECAP00000007919.3};
GN Name=NETO2 {ECO:0000313|Ensembl:ENSECAP00000007919.3,
GN ECO:0000313|VGNC:VGNC:20690};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007919.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007919.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007919.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007919.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007919.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; F7BD49; -.
DR STRING; 9796.ENSECAP00000007919; -.
DR PaxDb; 9796-ENSECAP00000007919; -.
DR Ensembl; ENSECAT00000010278.4; ENSECAP00000007919.3; ENSECAG00000009754.4.
DR VGNC; VGNC:20690; NETO2.
DR GeneTree; ENSGT00940000156041; -.
DR HOGENOM; CLU_015228_0_1_1; -.
DR InParanoid; F7BD49; -.
DR OMA; KECIYVL; -.
DR OrthoDB; 3024898at2759; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000009754; Expressed in endometrium and 23 other cell types or tissues.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IBA:GO_Central.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF26; NEUROPILIN AND TOLLOID-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..523
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040322663"
FT TRANSMEM 348..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..159
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 175..290
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 45..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 295..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 302..320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 314..329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 523 AA; 59007 MW; 88CFD71483B44814 CRC64;
MALEQLCAAL KVLLITVLVV EGIAVAQKTQ DGQNIGMKHI PATQCGTWVR TSNGGHFASP
NYPDSYPPNK ECIYVLEAAP RQRIELTFDE RYYIEPSFEC RFDHLEVRDG PFGFSPLIDR
YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DFTYLGGILN PIPDCQFELS
GADGVVRSSQ VEQEGKTKPG QAVDCIWTIK ATPRAKIYLR FLDYQMEHSN ECKRNFVAVY
DGSSSIENLK AKFCSTVAND IMLKTGVGVI RMWADEGSRL SRFRMLFTSF VEPPCTGSTF
FCHSSMCINN SLVCNGVQNC AYPWDENHCK EKKKAGLFEQ ITKTHGTIIG ITSGVVLVLL
IISILVQVKQ PRKKVMTCKT AFNKTGFQEV FDPPHYELFS LRDKEISADL ADLSEELDSY
QKLRRSSTAS RCVHDHHCGS QSSSTKQSRT NLSSMELPFR NDFAQPQPMK TFNSTFKKSS
YTFKQAHECP EQALEDRVME EIPCEIYVRG REDSAQASIS IDF
//
