ID F7BFE3_XENTR Unreviewed; 735 AA.
AC F7BFE3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 2 {ECO:0000256|ARBA:ARBA00020977};
DE AltName: Full=Component of oligomeric Golgi complex 2 {ECO:0000256|ARBA:ARBA00031344};
GN Name=cog2 {ECO:0000313|Ensembl:ENSXETP00000050424,
GN ECO:0000313|RefSeq:XP_004914700.2,
GN ECO:0000313|Xenbase:XB-GENE-962435};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000050424};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000050424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000050424};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000050424}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004914700.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004914700.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004914700.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the COG2 family.
CC {ECO:0000256|ARBA:ARBA00007603}.
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DR RefSeq; XP_004914700.2; XM_004914643.4.
DR Ensembl; ENSXETT00000050424; ENSXETP00000050424; ENSXETG00000023340.
DR AGR; Xenbase:XB-GENE-962435; -.
DR Xenbase; XB-GENE-962435; cog2.
DR eggNOG; KOG2307; Eukaryota.
DR HOGENOM; CLU_005470_0_0_1; -.
DR OMA; CWAEGVY; -.
DR OrthoDB; 35909at2759; -.
DR TreeFam; TF105824; -.
DR Reactome; R-XTR-6807878; COPI-mediated anterograde transport.
DR Reactome; R-XTR-6811438; Intra-Golgi traffic.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000023340; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007030; P:Golgi organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR009316; COG2.
DR InterPro; IPR024603; COG_complex_COG2_C.
DR InterPro; IPR024602; COG_su2_N.
DR PANTHER; PTHR12961; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2; 1.
DR PANTHER; PTHR12961:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2; 1.
DR Pfam; PF06148; COG2; 1.
DR Pfam; PF12022; COG2_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 16..147
FT /note="Conserved oligomeric Golgi complex subunit 2 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF06148"
FT DOMAIN 377..698
FT /note="COG complex component COG2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12022"
FT COILED 650..677
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 735 AA; 83689 MW; 625DF7FD068A34E6 CRC64;
MERVTMQLPQ GSPSMCFDKD EFMKDGFDVD VFVSECRKRV QLETLRDDLE LYYRLLKTAM
VELINKDYAD FVNLSTNLVG MDKALSQLSV PLGQLREEVL SLKTSVNEVI QAVDSRLAKQ
EDVRRKKMCV LTMMEVIHSV EKIEKILHSQ NSKETALEVK SPHLTGQILE RIATEFNQLQ
FHAVQSKGMP LLDNVRPRIA GITGMLQQSL EGLLLEGLQT SNVDTVRHCL RTYATIDKTR
DAEALVGQVL VKPYVDEVIN EQYVQSHPGG LHAMYSKLLE FVPHHCRLLR EVTGGAVSSE
NTDTVPGYDF LVNSIWPEIA RGLEEKLPSL FNPGNPDVFF QKYTTSMDFV RKFERQCGSQ
ASVKRLRSHP SYHSFNNKWN LPVYFQLRFK EIAGNLEAAL LHGHEEAPAE SKYCLRATHI
LWSCLLSCWS NEVFLPKLAH RFWKLTLQII SRYCSFIKEV ALHTCSDASN NEMKNHPSNY
RDSVTMSVAG NDDQDSGSTS DTRVTVKIST RQLMLFVADA DKFKLQLPEL REIIIVKLQQ
IGFKNISMIT GALEDTHQLL SPSLLAIKNK IVFDLSESCF SNLKSALEVP RLYRRTNKEM
PTKASSYVDN AVKPLFQLQN EYQNILTQSI REEWLTDVLS ECTPKYYDTI SDVLSSVKKM
EESLKRLKQA RKTVTSTNTT NAGNSDDNKI RLQLALDVEY FGDQVEKLGL QKHDIKSLQT
LTELVYTAKE QANTE
//
