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Database: UniProt
Entry: F7BHL0_MOUSE
LinkDB: F7BHL0_MOUSE
Original site: F7BHL0_MOUSE 
ID   F7BHL0_MOUSE            Unreviewed;      1055 AA.
AC   F7BHL0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 2.
DT   25-OCT-2017, entry version 57.
DE   SubName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000313|Ensembl:ENSMUSP00000108042};
GN   Name=Kcnma1 {ECO:0000313|Ensembl:ENSMUSP00000108042,
GN   ECO:0000313|MGI:MGI:99923};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000108042, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000108042, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108042,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000108042}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108042};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000108042}.
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DR   EMBL; AC154420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT010582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT025624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F7BHL0; -.
DR   SMR; F7BHL0; -.
DR   PaxDb; F7BHL0; -.
DR   PRIDE; F7BHL0; -.
DR   Ensembl; ENSMUST00000112423; ENSMUSP00000108042; ENSMUSG00000063142.
DR   MGI; MGI:99923; Kcnma1.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   Reactome; R-MMU-1296052; Ca2+ activated K+ channels.
DR   ChiTaRS; Kcnma1; mouse.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000063142; -.
DR   ExpressionAtlas; F7BHL0; baseline and differential.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Proteomics identification {ECO:0000213|MaxQB:F7BHL0,
KW   ECO:0000213|PeptideAtlas:F7BHL0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM      6     24       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     36     56       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    121    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    157    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    188    206       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    212       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1055 AA;  119018 MW;  709988D8309650D9 CRC64;
     QVVLVFALSI GALVIYFIDS SNPIESCQNF YKDFTLQIDM AFNVFFLLYF GLRFIAANDK
     LWFWLEVNSV VDFFTVPPVF VSVYLNRSWL GLRFLRALRL IQFSEILQFL NILKTSNSIK
     LVNLLSIFIS TWLTAAGFIH LVENSGDPWE NFQNNQALTY WECVYLLMVT MSTVGYGDVY
     AKTTLGRLFM VFFILGGLAM FASYVPEIIE LIGNRKKYGG SYSAVSGRKH IVVCGHITLE
     SVSNFLKDFL HKDRDDVNVE IVFLHNISPN LELEALFKRH FTQVEFYQGS VLNPHDLARV
     KIESADACLI LANKYCADPD AEDASNIMRV ISIKNYHPKI RIITQMLQYH NKAHLLNIPS
     WNWKEGDDAI CLAELKLGFI AQSCLAQGLS TMLANLFSMR SFIKIEEDTW QKYYLEGVSN
     EMYTEYLSSA FVGLSFPTVC ELCFVKLKLL MIAIEYKSAN RESRILINPG NHLKIQEGTL
     GFFIASDAKE VKRAFFYCKA CHDDVTDPKR IKKCGCRRLL HVEDEQPPTL SPKKKQRNGG
     MRNSPNTSPK LMRHDPLLIP GNDQIDNMDS NVKKYDSTGM FHWCAPKEIE KVILTRSEAA
     MTVLSGHVVV CIFGDVSSAL IGLRNLVMPL RASNFHYHEL KHIVFVGSIE YLKREWETLH
     NFPKVSILPG TPLSRADLRA VNINLCDMCV ILSANQNNID DTSLQDKECI LASLNIKSMQ
     FDDSIGVLQA NSQGFTPPGM DRSSPDNSPV HGMLRQPSIT TGVNIPIITE LVNDTNVQFL
     DQDDDDDPDT ELYLTQPFAC GTAFAVSVLD SLMSATYFND NILTLIRTLV TGGATPELEA
     LIAEENALRG GYSTPQTLAN RDRCRVAQLA LLDGPFADLG DGGCYGDLFC KALKTYNMLC
     FGIYRLRDAH LSTPSQCTKR YVITNPPYEF ELVPTDLIFC LMQFDHNAGQ SRASLSHSSH
     SSQSSSKKSS SVHSIPSTAN RPNRPKSRES RDKQNATRMT RMGQAEKKWF TDEPDNAYPR
     NIQIKPMSTH MANQINQYKS TSSLIPPIRE VEDEC
//
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