GenomeNet

Database: UniProt
Entry: F7BI55_MACMU
LinkDB: F7BI55_MACMU
Original site: F7BI55_MACMU 
ID   F7BI55_MACMU            Unreviewed;      4798 AA.
AC   F7BI55;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   22-NOV-2017, entry version 41.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMMUP00000006977};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMMUP00000006977};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000006977, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000006977, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000006977,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000006977}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000006977};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000006977}.
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DR   EMBL; JSUE03037911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9544.ENSMMUP00000006977; -.
DR   Ensembl; ENSMMUT00000007423; ENSMMUP00000006977; ENSMMUG00000005270.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F7BI55; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000006718; Chromosome 7.
DR   Bgee; ENSMMUG00000005270; -.
DR   ExpressionAtlas; F7BI55; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.20; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 12.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4122   4146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4346   4366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4414   4433       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4545   4563       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4606   4627       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4686   4709       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    332       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    399       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      526    737       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      953   1149       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1195   1407       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3854   3889       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4268   4295       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4798 AA;  543983 MW;  5A4D85FF3DA55722 CRC64;
     MGQWIARCSE GGRLQLEDEV VLQCIATIHK EQRKFCLAAE GLGNRLCFLE PTSEAKYIPP
     DLCVCNFVLE QSLSVRALQE MLANTGENGG EGAAQGGGHR TLLYGHAILL RHSFSGMYLT
     CLTTSRSQTD KLAFDVGLRE HATGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY
     LHLSVSNGNI QVDASFMQTL WNVHPTCSGS SIEEGYLLGG HVVRLFHGHD ECLTIPSTDQ
     NDSQHRRIFY EAGGAGTRAR SLWRVEPLRI SWSGSNIRWG QAFRLRHLTT GHYLALTEDQ
     GLILQDRAKA DTKSTAFSFR ASKELKEKLD SSHKRDIEGM GVPEIKYGDS VCFVQHIASG
     LWVTYKAQDA KTSRLGPLKR KVILHQEGHM DDGLTLQRCQ REESQAARII RNTTALFSQF
     VSGNNRTAAP ITLPIGEVLQ TLQDLIAYFQ PPEEEMRHED KQNKLRSLKN RQNLFKEEVI
     RLAFSSFYKL DRLESSSGIL EVLHCILTES PEALNLIAEG HIKSIISLLD KHGRNHKVLD
     ILCSLCLCNG VAVRANQNLI CDNLLPRRNL LLQTRLINDV TSIRPNIFLG VAEGSAQYKK
     WYFELIIDQV DPFLTAEPTH LRVGWASSSG YAPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WSGRIPRAVA SINQHLLRSD DVVSCCLDLG VPSISFRING QPVQGMFENF NTDGLFFPVM
     SFSAGVKVRF LMGGRHGEFK FLPPSGYAPC YEALLPKEKM RLEPVKEYKR DADGVRDLLG
     TTQFLSQASF IPCPIDTSQV VLPPHLEKIR DRLAENIHEL WGMNKIELGW TFGKIRDDNK
     RQHPCLVEFS KLPETEKNYN LQMSTETLKT LLALGCHIAH VNPAAEEDLK KVKLPKNYMM
     SNGYKPAPLD LSDVKLLPPQ EILVDKLAEN AHNVWAKDRI KQGWTYGIQQ DLKNKRNPRL
     VPYALLDERT KKSNRDSLRE AVRTFVGYGY NIEPSDQELA DSAVEKVSID KIRFFRVERS
     YAVRSGKWYF EFEVVTGGDM RVGWARPGCR PDVELGADDQ AFVFEGSRGQ RWHQGSGYFG
     RTWQPGDVVG CMINLDDASM IFTLNGELLI TNKGSELAFA DYEIENGFVP ICCLGLSQIG
     RMNLGTDAST FKFYTMCGLQ EGFEPFAVNM NRDVAMWFSK RLPTFVNVPK DHPHIEVMRI
     DGTMDSPPCL KVTHKTFGTQ HSNADMIYCR LSMPVECHSS FSHSPCLDSE AFQKRKQMQE
     ILSHTTTQCY YAIRIFAGQD PSCVWVGWVT PDYHLYSEKF DLNKNCTVTV TLGDERGRVH
     ESVKRSNCYM VWGGDIVASS QKSNRSNVDL EIGCLVDLAM GMLSFSANGK ELGTCYQVEP
     NTKVFPAVFL QPTSTSLFQF ELGKLKNAMP LSAAIFKSEE KNPVPQCPPR LDVQTIQPVL
     WSRMPNSFLK VESERVSERH GWVVQCLEPL QMMALHIPEE NRCVDILELC EQEDLMRFHY
     HTLRLYSAVC ALGNSRVAYA LCSHVDLSQL FYAIDNKYLP GLLRAGFYDL LISIHLANAK
     ERKLMMKNEY IIPITSTTRN IRLFPDESKR HGLPGVGLRT CLKPGFRFST PCFVATGEEH
     QKQSPEIPLE SLRTKALSML TEAVQCSGAH IRDPVGGSVE FQFVPVLKLI GTLLVMGVFD
     DDDVRQILLL IDPSVFGEHS ADTEEGTEKE EVTQVEEKAV EAGEKAGKEA PVKGLLQTRL
     PESVKLQMCE LLSYLCDCEL QHRVEAIVAF GDIYVSKLQA NQKFRYNELM QALNMSAALT
     ARKTKEFRSP PQEQINMLLN FQLGENCPCP EELREELYDF HEDLLLHCGV PLEEEEEEEE
     DTSWTGKLRA LVYKIKGPPK PEKEQPTEEE ERCPTTLKEL ISQTMICWAQ EDQIQDAELV
     RMMFNLLRRQ YDSIGELLQA LRKTYTISHA SVSDTINLLA ALGQIRSLLS VRMGKEEELL
     MINGLGDIMN NKVFYQHPNL MRVLGMHETV MEVMVNVLST EKSQIAFPKM VASCCRFLCY
     FCRISRQNQK AMFEHLSYLL ENSSVGLASP SMRGSTPLDV AASSVMDNNE LALGLEEPDL
     EKVVTYLAGC GLQSCPMLLA KGYPDVGWNP IEGERYLSFL RFAVFVNSES VEENASVVVK
     LLIRRPECFG PALRGEGGNG LLAAMQGAIK ISENPTLDLP SQGYKREVTE ADEEEEEIVH
     MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP
     SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD
     TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK
     AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL
     PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT
     RITATLEKQI SVDADGNFDP KPINTVNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY
     GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE
     NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG
     GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGVIVSR GMKDMELDAS SMEKRFAYKF
     LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PHDQEIKFFA KVLLPLVDQY FTNHRLYFLS
     SPLKPLSSSG YASHKEKEMV ASLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT
     VMKSGSELVK AGLRAFFENG AEDLEKTSEN LKLGKFTHSR TQIQGVSQNV NYTTVALLPI
     LTSIFEHVAQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA
     AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM CPDIPQLEGL MKEINDLAES
     GARYTEVPHV IEVILPMLCN YLSYWWERGP ENLPPSTGQC CTKVTSEHLS LILGNILKII
     NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLRADG
     KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI
     LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKSGG QDQERKKTKR RGDLYSIQTS
     LIVAALKKML PIGLNMCTPG DQELISLAKS RYGHRDTDEE VREHLRNNLH LQEKSDDPAV
     KWQLNLYKDV LKSEEPFNPE KTVERVQRIS AAVFHLEQVE QPLRSKKAVW HKLLSKQRKR
     AVVACFRMAP LYNLPRHRSI NLFLHGYQRF WIETEEYSFE EKLVQDLAKS PKVEEEEEEE
     TEKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA KSCQSGEDEE ADEDKEKTFE
     EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ
     KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT LIVRERGKFQ
     FLNDEFTRDL FRFLQLLCEG HNSDFQNFLR TQMGNTTTVN VIISTVDYLL RLQESISDFY
     WYYSGKDIID ESGQHNFSKA LAVTKQIFNS LTEYIQGPCI GNQQSLAHSR LWDAVVGFLH
     VFANMQMKLS QDSSQIELLK ELLDLLQDMV VMLLSLLEGN VVNGTIGKQM VDTLVESSTN
     VEMILKFFDM FLKLKDLTSS DTFKEYDPDG KGIISKREFQ KAMEGQKQYT QSEIDFLLSC
     AEADENDMFN YIDFVDRFHE PAKDIGFNVA VLLTNLSEHM PNDSRLKCLL DPAESVLNYF
     EPYLGRIEIM GGAKKIERVY FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEQEKMELF
     VNFCEDTIFE MQLASQISES DSADRPEEEE EGEDSSYVLE IAGEEEEDGS FEPASAFAMA
     CASVKRNVAD FLKRATLKNL RKQYRNVKKM TAKELVKVLC SFFWMLFLGL FQMLFTILGG
     IFQILWSTVF GGGLVEGAKN IRVTKILGDM PDPTQFGIHD DTMEAERAEV MEPGITTELV
     HFMKGEKGDT DIMSDLFGLH PKKEGSLKHG PEVGLGDLSE IIGKDEPPTL ESTVQKKRKA
     QAAEMKAANE AEGKVESEKA DVEDGEKEDK DKEEEQAEYL WTEVTKKKKR RCGQKAEKPE
     AFTANFFKGL DIYQTKLLHY LARNFYNLRF LALFVAFAIN FILLFYKVTE EPLEEETEDV
     ANLWNSFNDE EEEEAMVFFV LQESTGYMAP TLRALAIIHT IISLVCVVGY YCLKVPLVVF
     KREKEIARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF PNNYWDKFVK RKVINKYGDL
     YGAERIAELL GLDKNALDFS PVEETKAEAA SLVSWLSSID MKYHIWKLGV VFTDNSFLYL
     AWYTTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT
     VVAFNFFRKF YNKSEDDDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDPYEMY
     RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGNDYFDTTP
     HGFETHTLQE HNLANYLNKH PLFPLFQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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