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Database: UniProt
Entry: F7BKP4_CALJA
LinkDB: F7BKP4_CALJA
Original site: F7BKP4_CALJA 
ID   F7BKP4_CALJA            Unreviewed;      1782 AA.
AC   F7BKP4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 37.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSCJAP00000051432};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000051432, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000051432, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000051432}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000051432}.
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DR   EMBL; ACFV01039409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01039418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000061455; ENSCJAP00000051432; ENSCJAG00000007392.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000008225; Chromosome 15.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF239; PTHR10037:SF239; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    140    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    270    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    505    523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    543    563       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    651       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    748    773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    827    845       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    857    877       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    967    985       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1061   1084       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1218   1252       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      372    403       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1782 AA;  203301 MW;  4F90B0504693EC56 CRC64;
     VLSTEFSKER EKAKARGDFQ KLREKQQLEE DLKGYLDWIT QAEDIDPENE EEGGEEGKRN
     TSMPTSETES VNTENVSGEA ETRGCCRSLW CWWRRRGATK AGPSGCRRWG QAISKSKLSR
     RWRRWNRFNR RRCRAAVKSV TFYWLVIVLV FLNTLTISSE HYNQPDWLTQ IQDIANKVLL
     ALFTCEMLVK MYSLGLQAYF VSLFNRFDCF VVCGGITETI LVELEIMSPL GISVFRCVRL
     LRIFKVTRHW TSLSNLVASL LNSMKSIASL LLLLFLFIII FSLLGMQLFG GKFNFDETQT
     KRSTFDNFPQ ALLTVFQILT GEDWNAVMYD GIMAYGGPSS SGMIVCIYFI ILFICGNYIL
     LNVFLAIAVD NLADAESLNT AQKEEAEEKE RKKIARKESL ENKKNNKPEV NQVANSDNKV
     TIDDYREEDE DKDPYPPCDV PGDGEEQEGF ASYEPEVPAG PRPRRISELN MKEKIAPIPE
     GSAFFILSKT NPIRVGCHKL INHHIFTNLI LVFIMLSSAA LAAEDPIRSH SFRNTILGYF
     DYAFTAIFTV EILLKMTTFG AFLHKGAFCR NYFNLLDMLV VGVSLVSFGI QSSAISVVKI
     LRVLRVLRPL RAINRAKGLK HVVQCVFVAI RTIGNIMIVT TLLQFMFACI GVQLFKGKFY
     RCTDEAKSNP EECRGLFILY KDGDVDSPVV RERIWQNSDF NFDNVLSAMM ALFTVSTFEG
     WPALLYKAID SNGENVGPVY NHRVEISIFF IIYIIIVAFF MMNIFVGFVI VTFQEQGEKE
     YKNCELDKNQ RQCVEYALKA RPLRRYIPKN PYQYKFWYVV NSSPFEYMMF VLIMLNTLCL
     AMQHYEQSKM FNDAMDILNM VFTGVFTVEM VLKVIAFKPK HYFTDAWNTF DALIVVGSVV
     DIAITEVNPT ESETVPVPTA TPGNSVCSAC NSSFHIMLFK VMRLVKLLSR GEGIRTLLWT
     FIKSFQALPY VALLIAMLFF IYAVIGMQMF GKVAMKDNNQ INRNNNFQTF PQAVLLLFRK
     RCATGEAWQE IMLACLPGKL CDPESDYNPG EEYTCGSNFA IVYFISFYML CAFLIINLFV
     AVIMDNFDYL TRDWSILGPH HLDEFKRIWS EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK
     LCPHRVACKR LVAMNMPLNS DGTVMFNATL FALVRTALKI KTEGNLEQAN EELRAVIKKI
     WKKTSMKLLD QVVPPAGDDE VTVGKFYATF LIQDYFRKFK KRKEQGLVGK YPAKNTTIAL
     QAGLRTLHDI GPEIRRAISC DLQDDEPEEA KREEEDDVFK RNGALLGNHV NHVNSDRRDS
     LQQTNTTHRP LHVQRPSIPP ASDTEKPLFP PAGNSVCHNH HNHNSIGKQV PTSTNANLNN
     ANMSKAAHGK RPSIGNLEHV SENGHHSSHK HDREPQRRSS VKRTRYYETY IRSDSGDEQL
     PTICREDPEV HGYFRDPRCL GEQEYFSSEE CYEDDSSPTW SRQNYGYYSR YPGRNMDFER
     PRGYHQPQGF LEDDDSPICY DSRRSPRRRL LPPTPASHRR SSFNFECLRR QSSQEEIPSS
     PTFFPHRTAL PLHLMQQQIM AVAGLDSSKA QKYSPSHSTR SWATPPATPP YRDWTPCYTP
     LIQVEQSEAL DQVNGSLPSL HRSSWYTDEP DISYRTFTPA SLTIPSSFRN KNSDKQRSAD
     SLVEAVLISE GLGRYARDPK FVSATKYEIA DACDLTIDEM ESAASTLLNG NVRPRANGDV
     GPLSHQQDYE LQDFGPGYSD EEPDLGRDEE DLADEMICIT TL
//
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