ID F7BKQ6_HORSE Unreviewed; 1187 AA.
AC F7BKQ6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=MAN2A2 {ECO:0000313|Ensembl:ENSECAP00000016886.3,
GN ECO:0000313|VGNC:VGNC:19910};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016886.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016886.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016886.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016886.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016886.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR AlphaFoldDB; F7BKQ6; -.
DR STRING; 9796.ENSECAP00000016886; -.
DR PaxDb; 9796-ENSECAP00000016886; -.
DR Ensembl; ENSECAT00000020561.3; ENSECAP00000016886.3; ENSECAG00000018866.3.
DR VGNC; VGNC:19910; MAN2A2.
DR GeneTree; ENSGT01030000234638; -.
DR HOGENOM; CLU_004690_1_0_1; -.
DR InParanoid; F7BKQ6; -.
DR OMA; GHQWLKY; -.
DR TreeFam; TF313152; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000018866; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0004559; F:alpha-mannosidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0006491; P:N-glycan processing; IBA:GO_Central.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF57; ALPHA-MANNOSIDASE 2X; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 539..625
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 134653 MW; DDEFC77A717B3FA3 CRC64;
MYWGFWGEGG ERRKKEKEGR KGNLAAAHCP KVCVAASMKL KKQVTVCGAA IFCVAVFSLY
LMLDRVQHDP ARHQNGGNFP RSQISVLQNR IEQLEQLLEE NHEIISHIKD SVLELTANAE
GPPALLPYYT ANGSWVVPPE PRPSFFSISP QDCQFALGGR GQKPELQMLT ISEELPFDNV
DGGVWKQGFD ISYSPHDWDA EDLQVFVVPH SHNDPGWIKT FDKYYTEQTQ HILNSMVSKL
QEDPRRRFLW AEVSFFAKWW DNINAQKRAA VRRLVGNGQL EIATGGWVMP DEANSHYFAL
IDQLIEGHQW LERNLGVTPR SGWAVDPFGY SPTMPYLLRR ANLTSMLIQR VHYAIKKHFA
ATHSLEFMWR QTWDSDSSTD IFCHMMPFYS YDIPHTCGPD PKICCQFDFK RLPGGRINCP
WKVPPRAITE ANVAERAALL LDQYRKKSRL FRSNVLLVPL GDDFRYDKPQ EWDAQFFNYQ
RLFDFLNSKP DLHVQAQFGT VSDYFDALYK RTGVEPGARP PGFPVLSGDF FSYADREDHY
WTGYYTSRPF YKSLDRVLEA HLRGAEILYS LAVAHARRSG LASQYPLSNF ALLTEARRTL
GLFQHHDAIT GTAKEAVVVD YGVRLLRSLV SLKQVIINAA HYLVLGDKET YHFDPEAPFL
QMDDTRLNHD ALPERTVIQL DSSPRYVVLF NPLEQERLSV VSLLVSSPRV RVLSEEGQPL
AVQISAHWSS ATDMVPDVYQ VSVPVRLLAL GLGVLQLQLG LDGHRTLPSS VRVYLHGRPL
SVSRHEAFPL RVIDSGTSDF ALSNRYMQVW FSGLTGLLKS IRRLDEERER RVDMEFLVYG
TRTSKDKSGA YLFLPDGEAQ PYVPKDHPVL RVTEGPFFSE VVAYYEHVHQ VVRLYNLPGV
EGLSLDMSSL VDIRDYVNKE LALRIRTDID SQGTFFTDLN GFQVQPRRYL KKLPLQANFY
PMPVMAYIQD AQNRLTLHTA QALGVSSLHD GQLEVILDRR LMQDDNRGLG QGLKDNKRTR
NHFRLLLERR TLGSEVPDSH STSYPSLLSH LTSMYLNTPA LALPVAKRQL PAPGLRSFHP
LASSLPCDFH LVNLRTLQAE EDALPSAETA LILHRKGFDC GLEAKNLGFN CTTSQGKVAL
GSLFHGLDVG FLQPTSLTLL YPLASPSNST DIYLEPMEIA TFRLRLG
//
