ID F7BPX9_CALJA Unreviewed; 1429 AA.
AC F7BPX9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=YTHDC2 {ECO:0000313|EMBL:JAB26985.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB26985.1};
RN [1] {ECO:0000313|EMBL:JAB26985.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB04814.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB43225.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB26985.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB20070.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; GAMT01007047; JAB04814.1; -; mRNA.
DR EMBL; GAMS01003066; JAB20070.1; -; mRNA.
DR EMBL; GAMR01006947; JAB26985.1; -; mRNA.
DR EMBL; GAMP01009530; JAB43225.1; -; mRNA.
DR RefSeq; XP_002744748.1; XM_002744702.4.
DR GeneID; 100413395; -.
DR KEGG; cjc:100413395; -.
DR CTD; 64848; -.
DR eggNOG; KOG0920; Eukaryota.
DR eggNOG; KOG0922; Eukaryota.
DR eggNOG; KOG1902; Eukaryota.
DR OrthoDB; 1095660at2759; -.
DR TreeFam; TF318311; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:JAB26985.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 37..105
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 202..368
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 505..537
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 611..783
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1287..1417
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1429 AA; 160406 MW; BE36EE86536DBEF0 CRC64;
MSRPSSVSPR QRALGGGGGG PAPCGPGGGG RAKGLKDIRI DEEVKIAVNI ALERFRYGDQ
REMEFPSSLT STERAFIHRL SQSLGLVSKS KGKGANRYLT VKKKDGSETA HAMMTCNLTH
NTKHAVRSLI QRFPVTNKER TELLPKTERG NVFAVEAENR EMSKTSGRLN NGIPQIPVKR
GESEFDSFRQ SLPVFEKQEE IVKIIKENKV VLIVGETGSG KTTQIPQFLL DDCFKNGIPC
RIFCTQPRRL AAIAVAERVA AERRERIGQT IGYQIRLESR VSPKTLLTFC TNGVLLRTLM
AGDSTLSTVT HVIVDEVHER DRFSDFLLTK LRDLLQKHPT LKLILSSAAL DVNLFIRYFG
SCPVIYIQGR PFEVKEMFLE DILRTTGYTN KEMLKYKNEK QQEEKQQTTL TEWYSAQENT
FKPESQRQRT VPNVTDEYDL LDDGGDAIFS QLTEKDVNCL EPWLIKEMDA CLSDIWLHKD
IDAFAQVFHL ILTENVSVDY RHSETSATAL MVAAGRGFAS QVEQLISMGA NVHSKASNGW
MALDWAKHFG QTEIVDLLES YSASLEFGNL DESPLVQTNG SDLSAEDREL LKAYHHSFDD
EKVDLDLIMH LLYNICHSCD AGAVLIFLPG YDEIVGLRDR ILFDDKRFAD NTHRYQVFML
HSNMQTSDQK KVLKNPPAGV QKIILSTNIA ETSITVNDVV FVIDSGKVKE KSFDALNFVT
MLKMVWISKA SAIQRKGRAG RCRPGICFRL FSRLRFQNML EFQTPELLRM PLQELCLHTK
LLAPVNCPIA DFLMKAPEPP PALIIRNAVQ MLKTIDAMDT WEDMTELGYH LADLPVEPHL
GKMVLCAVVL KCLDPILTIA CTLAYRDPFV LPTQASQKRA AMLCRKRFTA GTFSDHMALL
RAFQAWQKAR SDGWERAFCE KNFLSQAAME IIIGMRTQLL GQLRASGFVR ARGGGDIRDV
NTNSENWAVV KAALVAGMYP NLVHVDRENV VLTGPKEKKV RFHPTSVLSQ PQYKKIPPVN
GQAAAIQALP TDWLIYDEMT RAHRIANIRC CSAVTPVTVL VFCGPARLAS NALQEPSSFR
VDGIPNDSSD SEMEDKTTAN LAALKLDEWL NFKLEPEAAS LLLQLRQKWH NLFLRRMRAP
SKPWSQVDEA TIRAIIAVLS TEEQSAGLQQ PSGIGQRPRP MSSEELPLAS SWRSNNSRKC
SADTEFSDEC TTTERVLMKS PSPALHPPQK YKDRGILHTK RGTDDRSDQS SVKSTDSSSY
PSPCASPSPP SSGKGSKSPS PRPNMPIRYF IMKSSNLRNL EISQQKGIWS TTPSNERKLN
RAFWESSMVY LVFSVQGSGH FQGFSRMSSE IGREKSQDWG SAGLGGVFKV EWIRKESLPF
QFAHHLLNPW NDNKKVQISR DGQELEPQVG EQLLQLWERL PLGEKNTTD
//
