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Database: UniProt
Entry: F7BQB6_XENTR
LinkDB: F7BQB6_XENTR
Original site: F7BQB6_XENTR 
ID   F7BQB6_XENTR            Unreviewed;       829 AA.
AC   F7BQB6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   22-NOV-2017, entry version 47.
DE   SubName: Full=Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 {ECO:0000313|Ensembl:ENSXETP00000011327};
GN   Name=hcn4 {ECO:0000313|Ensembl:ENSXETP00000011327};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000011327, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000011327}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000011327};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000011327}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXETP00000011327}.
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DR   EMBL; AAMC01035222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01035223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01035224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000011327; -.
DR   PaxDb; F7BQB6; -.
DR   Ensembl; ENSXETT00000011327; ENSXETP00000011327; ENSXETG00000005192.
DR   Xenbase; XB-GENE-940130; hcn4.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; F7BQB6; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   TreeFam; TF318250; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000005192; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:InterPro.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030173; HCN4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF375; PTHR10217:SF375; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    228    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    258    277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    457    480       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      558    673       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   829 AA;  93904 MW;  9712C20DD9CA67CC CRC64;
     MDRLHPSMRK RLYSLPQHIG FKASIMDEAE CEERDTWRKS IKLKPLPSPS ALRVLDPRHG
     AKETHIVMET EVGKAQRTSS NGDCRRFTGS LSSITSCGRH LHDADPSEGR RLISDGDISP
     TEECSPTLDP AVGESNIHLS QNTQTSSQCQ GAEQLSSPGK LDGREQTLSG GEDEQGSFMH
     RQFGALLQPG VNKFSLRMFG SQKAVEREQD RVKSAGFWII HPYSDFRFYW DLTMLLLMVG
     NLIIIPVGIT FFKEENTPAW IVFNVVSDTF FLVDLVLNFR TGIVLEDNTE IILEPQRIKI
     RYLKSWFLVD FVSSIPVDYI FLIVETRIDS EVYKTARALR IVRFAKVLSL LRLLRLSRLI
     RYIHQWEEVC HCLYLSTSSK GRAPLQLIRF RLLLHGSLST LVSILRPKKY KCYAYHNIML
     NASWGKQYSY ALFKAMSHML CIGYGQQAPV GMGDVWLTML SMIVGATCYA MFIGHATALI
     QSLDSSRRQY QEKYKQVEQY MSFHKLPADL RQRIHDYYEH RYQGKMFDEE SILGELSEPL
     REEIINFNCR KLVASMPLFA NADPNFVTSM LTKLRFEVFQ PGDYLIREGT VGKKMFFIQH
     GVVSILSKGS KETKLSDGSY FGEICLLTRG RRTASVRADT YCRLYSLSVD HFNEVLEEYP
     MMRRAFESVA LDRLDRIGKK NSLLLHKVQH DLRSGVLNYH ENEIIQQIVQ HDREMAQGPR
     CSQTEEESTS LPATPVIWTP LVQAPLRAAA ATTSVAIPLT HQRIPATIFR PAPSALGVTA
     RGLRQAQRTA LPTHLIGIEG AVSQPSSFHV HQLAGFSAAA CVSPAPPPS
//
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