ID F7BQW5_XENTR Unreviewed; 400 AA.
AC F7BQW5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Homeobox protein Meis2 isoform X3 {ECO:0000313|RefSeq:XP_012823257.1};
DE SubName: Full=Meis homeobox 2 {ECO:0000313|Ensembl:ENSXETP00000028193};
GN Name=meis2 {ECO:0000313|Ensembl:ENSXETP00000028193,
GN ECO:0000313|RefSeq:XP_012823257.1,
GN ECO:0000313|Xenbase:XB-GENE-487675};
GN Synonyms=hst18361 {ECO:0000313|RefSeq:XP_012823257.1}, mrg1
GN {ECO:0000313|RefSeq:XP_012823257.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000028193};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000028193}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000028193};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000028193}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012823257.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012823257.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012823257.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC {ECO:0000256|ARBA:ARBA00009661}.
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DR RefSeq; XP_012823257.1; XM_012967803.3.
DR Ensembl; ENSXETT00000028193; ENSXETP00000028193; ENSXETG00000012882.
DR GeneID; 100036664; -.
DR AGR; Xenbase:XB-GENE-487675; -.
DR AGR; Xenbase:XB-GENE-961419; -.
DR CTD; 4212; -.
DR Xenbase; XB-GENE-487675; meis2.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_023139_1_1_1; -.
DR OrthoDB; 53219at2759; -.
DR TreeFam; TF318093; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Bgee; ENSXETG00000012882; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF47; HOMEOBOX PROTEIN MEIS2; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000313|RefSeq:XP_012823257.1};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 273..336
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 275..337
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 192..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 43834 MW; 080D110C019CE6C4 CRC64;
MAQRYDELPH YGMDGVGVPT SMYGDPHAPR PIPPVHHLNH GPPLHASQHY GTHAPHPNVM
PTSMGSAVND ALKRDKDAIY GHPLFPLLAL VFEKCELATC TPREPGVAGG DVCSSDSFNE
DIAVFAKQVR AEKPLFSSNP ELDNLMIQAI QVLRFHLLEL EKVHELCDNF CHRYISCLKG
KMPIDLVIDE RDGSSKSDHE ELSGSSTNLA DHNPASWRDH DDAVSTHSAG TPGPSSGGHA
SQSGDNSSEQ GDVLDNSVAS PGTGDDDDPD KDKKRQKKRG IFPKVATNIM RAWLFQHLTH
PYPSEEQKKQ LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRAGFLLDP SVSQGAAYSP
EGQPMGSFVL DGQQHMGIRP AGPMSGMGMN MGMDGQWHYM
//
