ID F7BS88_HORSE Unreviewed; 340 AA.
AC F7BS88;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Serine/threonine/tyrosine interacting like 1 {ECO:0000313|Ensembl:ENSECAP00000016833.3};
GN Name=STYXL1 {ECO:0000313|VGNC:VGNC:23740};
GN Synonyms=TMEM120A {ECO:0000313|Ensembl:ENSECAP00000016833.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016833.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016833.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016833.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016833.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016833.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7BS88; -.
DR Ensembl; ENSECAT00000020504.3; ENSECAP00000016833.3; ENSECAG00000019261.4.
DR VGNC; VGNC:23740; STYXL1.
DR GeneTree; ENSGT00390000010113; -.
DR HOGENOM; CLU_027074_1_1_1; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000019261; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; F7BS88; baseline.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14517; DSP_STYXL1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR46659; SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR46659:SF1; SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 1; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 187..330
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
SQ SEQUENCE 340 AA; 39059 MW; ED52F60A112A5DD2 CRC64;
MGAPPIRRSR ALPCSHPRWF RPPCRGPSRM ADLVLCEPIE LYNILNQVTK LSRLTEPNYL
CLLDVRSKRE YDESHVITAR RVKKKANEYL IPESVDLECV KYCVVYDNNT SFLEILRHSS
DDDVSDESRE GPVLGAAIKC GKALTHLTRH PVRILKGGYE RFSAMYHFFR TQKIIWMPQE
LDAFQPYPVE IMPGKIYLGN FRQACDPKIQ KDLKIKAHVN VSMETGPFFT GDADKLLHIQ
IEDSPEANIS PFLRHVCHFV EIHLELGSVI LVFSTLGISR SCAAILAYLM HRNEQTLKRS
WAYVKKCQNN MCPNQGLVTQ LLEWEKIVLG DLVTDIKDLY
//
